Zobrazeno 1 - 10
of 75
pro vyhledávání: '"Constanze, Hantel"'
Autor:
Edlira Luca, Andrea Abate, Katharina Wang, Stefan Bornstein, Sandra Sigala, Felix Beuschlein, Svenja Nölting, Constanze Hantel
Publikováno v:
Endocrines, Vol 5, Iss 3, Pp 261-276 (2024)
Adrenocortical carcinoma (ACC) and pheochromocytoma (PCC) are malignancies originating from distinct layers of the adrenal gland. ACCs arise from the adrenal cortex, are often detected at advanced stages and are associated with poor prognosis. PCCs a
Externí odkaz:
https://doaj.org/article/a75ff68657c54953a66152da4a7cf44d
Autor:
Emily Warmington, Gabrielle Smith, Vasileios Chortis, Raimunde Liang, Juliane Lippert, Sonja Steinhauer, Laura-Sophie Landwehr, Constanze Hantel, Katja Kiseljak-Vassiliades, Margaret E Wierman, Barbara Altieri, Paul A Foster, Cristina L Ronchi
Publikováno v:
Endocrine Connections, Vol 13, Iss 1, Pp 1-12 (2023)
Adrenocortical carcinoma (ACC) is an aggressive malignancy with limited treatment options. Polo-like kinase 1 (PLK1) is a promising drug target; PLK1 inhibitors (PLK1i) have been investigated in solid cancers and are more effective in TP53-mutated ca
Externí odkaz:
https://doaj.org/article/e4efec62f5f64d8ab3df24cff09f9c14
Autor:
Gwenneg Kerdivel, Floriane Amrouche, Marie-Ange Calmejane, Floriane Carallis, Juliette Hamroune, Constanze Hantel, Jérôme Bertherat, Guillaume Assié, Valentina Boeva
Publikováno v:
Clinical Epigenetics, Vol 15, Iss 1, Pp 1-17 (2023)
Abstract Background Adrenocortical carcinoma is rare and aggressive endocrine cancer of the adrenal gland. Within adrenocortical carcinoma, a recently described subtype characterized by a CpG island methylator phenotype (CIMP) has been associated wit
Externí odkaz:
https://doaj.org/article/c76717b318a742faa83e043eb3df2200
Autor:
Stefan Bornstein, Igor Shapiro, Maria Malyukov, Richard Züllig, Edlira Luca, Evgeny Gelfgat, Felix Beuschlein, Svenja Nölting, Alfredo Berruti, Sandra Sigala, Mirko Peitzsch, Charlotte Steenblock, Barbara Ludwig, Patrick Kugelmeier, Constanze Hantel
Publikováno v:
Cell Death and Disease, Vol 13, Iss 7, Pp 1-11 (2022)
Abstract The adrenal gland provides an important function by integrating neuronal, immune, vascular, metabolic and endocrine signals under a common organ capsule. It is the central organ of the stress response system and has been implicated in numero
Externí odkaz:
https://doaj.org/article/d0c5a29e487942f0a4e1dd140e394cfa
Autor:
Sandra Sigala, Christina Bothou, David Penton, Andrea Abate, Mirko Peitzsch, Deborah Cosentini, Guido A. M. Tiberio, Stefan R. Bornstein, Alfredo Berruti, Constanze Hantel
Publikováno v:
Cells, Vol 12, Iss 18, p 2274 (2023)
The authors made the following changes to their paper [...]
Externí odkaz:
https://doaj.org/article/d15a5a41225746c0b2555cc5752f7cb5
Autor:
Mariangela Tamburello, Andrea Abate, Elisa Rossini, Ram Manohar Basnet, Daniela Zizioli, Deborah Cosentini, Constanze Hantel, Marta Laganà, Guido Alberto Massimo Tiberio, Salvatore Grisanti, Maurizio Memo, Alfredo Berruti, Sandra Sigala
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 7, p 6829 (2023)
Background: Adrenocortical cancer (ACC) is a rare malignancy with a dismal prognosis. The treatment includes mitotane and EDP chemotherapy (etoposide, doxorubicin, and cisplatin). However, new therapeutic approaches for advanced ACC are needed, parti
Externí odkaz:
https://doaj.org/article/ca50272ad95a4ac68371cac657d07666
Autor:
Iuliu Sbiera, Stefan Kircher, Barbara Altieri, Kerstin Lenz, Constanze Hantel, Martin Fassnacht, Silviu Sbiera, Matthias Kroiss
Publikováno v:
Frontiers in Endocrinology, Vol 12 (2021)
Adrenocortical carcinoma (ACC) is a rare endocrine malignancy and treatment of advanced disease is challenging. Clinical trials with multi-tyrosine kinase inhibitors in the past have yielded disappointing results. Here, we investigated fibroblast gro
Externí odkaz:
https://doaj.org/article/9e83a1edfae5460297374a0abbff6473
Publikováno v:
Pharmaceutics, Vol 14, Iss 9, p 1891 (2022)
Adrenocortical carcinoma (ACC) is a heterogeneous malignancy related to poor prognosis and limited treatment options. The orphan drug mitotane (MT) is still a cornerstone in ACC therapy, however, its application is characterized by low aqueous solubi
Externí odkaz:
https://doaj.org/article/208a7b778d054d33979c054205cc1e5d
Autor:
Elisa Rossini, Mariangela Tamburello, Andrea Abate, Silvia Beretta, Martina Fragni, Manuela Cominelli, Deborah Cosentini, Constanze Hantel, Federica Bono, Salvatore Grisanti, Pietro Luigi Poliani, Guido A. M. Tiberio, Maurizio Memo, Sandra Sigala, Alfredo Berruti
Publikováno v:
Frontiers in Endocrinology, Vol 12 (2021)
Progesterone (Pg) and estrogen (E) receptors (PgRs and ERs) are expressed in normal and neoplastic adrenal cortex, but their role is not fully understood. In literature, Pg demonstrated cytotoxic activity on AdrenoCortical Carcinoma (ACC) cells, whil
Externí odkaz:
https://doaj.org/article/c09dc65c25df413bb02ebe92623d692c
Autor:
Sandra Sigala, Christina Bothou, David Penton, Andrea Abate, Mirko Peitzsch, Deborah Cosentini, Guido A. M. Tiberio, Stefan R. Bornstein, Alfredo Berruti, Constanze Hantel
Publikováno v:
Cells, Vol 11, Iss 9, p 1439 (2022)
Adrenocortical carcinoma is a heterogeneous and aggressive cancer that originates from steroidogenic cells within the adrenal cortex. In this study, we have assessed for the preclinical gold standard NCI-H295 in direct comparison with the more recent
Externí odkaz:
https://doaj.org/article/c77753277dde4360a30f788f6ef8fe71