Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Constantinos Markopoulos"'
Publikováno v:
Oral Drug Delivery for Modified Release Formulations. :305-324
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e859e6e08368a0961594c766af0c16a1
https://doi.org/10.1002/9781119772729.ch17
https://doi.org/10.1002/9781119772729.ch17
Autor:
Constantinos Markopoulos, Ying Chen Chen, Cord J. Andreas, Jennifer B. Dressman, Christos Reppas
Publikováno v:
European Journal of Pharmaceutics and Biopharmaceutics. 97:39-50
Aims Postprandial administration of solid oral dosage forms greatly changes the dissolution environment compared to fasted state administration. The aims of this study were to investigate and forecast the effect of co-administration of a meal on drug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93dacb8a5dab903b09bac6f8f8383c19
https://doi.org/10.1016/j.ejpb.2015.09.002
https://doi.org/10.1016/j.ejpb.2015.09.002
Autor:
Filippos Kesisoglou, Mira Symillides, Maria Vertzoni, Christos Reppas, Constantinos Markopoulos
Publikováno v:
Journal of Pharmaceutical Sciences. 104:2986-2997
The purpose was to propose two-stage single-compartment models for evaluating dissolution characteristics in distal ileum and ascending colon, under conditions simulating the bioavailability and bioequivalence studies in fasted and fed state by using
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72584b25f462fbca871e779cc8f48716
https://doi.org/10.1002/jps.24485
https://doi.org/10.1002/jps.24485
Autor:
Cord J. Andreas, Christos Reppas, Constantinos Markopoulos, Jennifer B. Dressman, Maria Vertzoni
Publikováno v:
European Journal of Pharmaceutics and Biopharmaceutics. 93:173-182
Background Biorelevant media for evaluation of dosage form performance in the gastrointestinal lumen were first introduced in the late 1990s. Since then, a variety of additional media have been proposed, making it now possible to simulate most region
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::718b3772b3f2ddc47003ba7ba63fb6f2
https://doi.org/10.1016/j.ejpb.2015.03.009
https://doi.org/10.1016/j.ejpb.2015.03.009
Autor:
Maria Vertzoni, Christos Reppas, Constantinos Markopoulos, Constantinos Goumas, Eleni Karatza
Publikováno v:
Pharmaceutical Research. 32:3338-3349
Characterize the contents of distal ileum and cecum in healthy adults under conditions simulating the bioavailability/bioequivelance studies of drug products in fasted and fed state.Twelve males participated in a two-phase crossover study. Phase I: s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3d5c54e57081a6bbc1307f990274901
https://doi.org/10.1007/s11095-015-1710-6
https://doi.org/10.1007/s11095-015-1710-6
Autor:
Mira Symillides, Constantinos Markopoulos, Christos Reppas, Neil Parrott, Georgios Imanidis, Maria Vertzoni
Publikováno v:
Pharmaceutical Research. 30:3145-3153
Evaluate the impact of luminal micellar phase on passive permeability of five lipophilic (1.9 ≤ clogP ≤ 9.0) small molecules using biorelevant media and evaluate the impact of luminal coarse lipid particles on danazol permeability after oral admi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85cd374c874c802a1c56f191826c7f34
https://doi.org/10.1007/s11095-013-1141-1
https://doi.org/10.1007/s11095-013-1141-1
Autor:
Constantinos Markopoulos, Xavier Pepin, Maria Vertzoni, Jennifer B. Dressman, Cord J. Andreas, Christos Reppas
Publikováno v:
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 102
When administered orally as either an immediate or modified release dosage form, zolpidem demonstrates a negative food effect, i.e. decrease in CPharmacokinetic profiles of zolpidem are presented from a bioavailability (8mg intravenous; 10mg immediat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::211623e90806b77463ebf27ab855b3c6
https://pubmed.ncbi.nlm.nih.gov/28286289
https://pubmed.ncbi.nlm.nih.gov/28286289
Autor:
Christos Reppas, Constantinos Markopoulos, Apostolos Agalias, Maria Vertzoni, Prokopios Magiatis
Publikováno v:
Journal of Pharmacy and Pharmacology. 61:143-149
Objectives We aimed to assess the intralumenal stability of oleuropein in human gastric and small intestinal contents. We additionally aimed to assess the stability characteristics of oleuropein in media simulating the intralumenal conditions. Method
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86de9dd915abff1ed9d06ee812565699
https://doi.org/10.1211/jpp.61.02.0002
https://doi.org/10.1211/jpp.61.02.0002
Autor:
Constantinos Markopoulos, M. Symillides, Christos Reppas, Maria Vertzoni, Georgios Imanidis, F Thoenen, Daniel Preisig, Neil Parrott
Publikováno v:
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 86(3)
In this work we developed and characterized transport media that simulate the composition of micellar phase of intestinal fluids in the fasted and, especially, in the fed state and are appropriate for evaluating intestinal drug permeability character
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51a8f3a14bfbb2f45c4c0c61b8bd7476
https://pubmed.ncbi.nlm.nih.gov/24184673
https://pubmed.ncbi.nlm.nih.gov/24184673
Autor:
Constantinos Markopoulos, Georgios Imanidis, Constantinos Goumas, M. Symillides, Christos Reppas, Maria Vertzoni
Publikováno v:
Molecular pharmaceutics. 9(5)
The first aim of this study was to characterize the luminal contents and their micellar phase after the administration of a heterogeneous liquid meal to healthy adults. The second aim was to evaluate the impact of micellar lipids and coarse lipid par
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09525a00da66a1cca9cd49c7410b1700
https://pubmed.ncbi.nlm.nih.gov/22482927
https://pubmed.ncbi.nlm.nih.gov/22482927