Zobrazeno 1 - 10
of 113
pro vyhledávání: '"Constantinos M Mikelis"'
Autor:
Colleen L Doçi, Constantinos M Mikelis, Juan Luis Callejas-Valera, Karina K Hansen, Alfredo A Molinolo, Asuka Inoue, Stefan Offermanns, J Silvio Gutkind
Publikováno v:
PLoS ONE, Vol 12, Iss 3, p e0173692 (2017)
G-protein coupled receptors (GPCRs), which activate heterotrimeric G proteins, are an essential class of transmembrane receptors that are responsible for a myriad of signaling events in normal and pathologic conditions. Two members of the G protein f
Externí odkaz:
https://doaj.org/article/df420c4435414d65b2c0651af441b2d3
Autor:
Rebecca A Drummond, Amanda L Collar, Muthulekha Swamydas, Carlos A Rodriguez, Jean K Lim, Laura M Mendez, Danielle L Fink, Amy P Hsu, Bing Zhai, Hatice Karauzum, Constantinos M Mikelis, Stacey R Rose, Elise M N Ferre, Lynne Yockey, Kimberly Lemberg, Hye Sun Kuehn, Sergio D Rosenzweig, Xin Lin, Prashant Chittiboina, Sandip K Datta, Thomas H Belhorn, Eric T Weimer, Michelle L Hernandez, Tobias M Hohl, Douglas B Kuhns, Michail S Lionakis
Publikováno v:
PLoS Pathogens, Vol 11, Iss 12, p e1005293 (2015)
Candida is the most common human fungal pathogen and causes systemic infections that require neutrophils for effective host defense. Humans deficient in the C-type lectin pathway adaptor protein CARD9 develop spontaneous fungal disease that targets t
Externí odkaz:
https://doaj.org/article/099f504b30074aaf88ba805ec83e4484
Publikováno v:
International Journal of Pharmaceutics: X, Vol 8, Iss , Pp 100283- (2024)
Nucleic acid-based therapeutics are a common approach that is increasingly popular for a wide spectrum of diseases. Lipid nanoparticles (LNPs) are promising delivery carriers that provide RNA stability, with strong transfection efficiency, favorable
Externí odkaz:
https://doaj.org/article/62d5d52309ca49e1ab221e2ce81a6c1b
Autor:
Archana Shrestha, Behnaz Lahooti, A. K. M. Nawshad Hossian, Mahboubeh Madadi, Constantinos M. Mikelis, George Mattheolabakis
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 8, p 4432 (2024)
The mainstays of lung cancer pathogenesis are cell cycle progression dysregulation, impaired apoptosis, and unregulated cell proliferation. While individual microRNA (miR) targeting or delivering is a promising approach that has been extensively stud
Externí odkaz:
https://doaj.org/article/5678caba4dca4c77804a1d6c698a485f
Autor:
Rebecca A. Drummond, Jigar V. Desai, Amy P. Hsu, Vasileios Oikonomou, Donald C. Vinh, Joshua A. Acklin, Michael S. Abers, Magdalena A. Walkiewicz, Sarah L. Anzick, Muthulekha Swamydas, Simon Vautier, Mukil Natarajan, Andrew J. Oler, Daisuke Yamanaka, Katrin D. Mayer-Barber, Yoichiro Iwakura, David Bianchi, Brian Driscoll, Ken Hauck, Ahnika Kline, Nicholas S.P. Viall, Christa S. Zerbe, Elise M.N. Ferré, Monica M. Schmitt, Tom DiMaggio, Stefania Pittaluga, John A. Butman, Adrian M. Zelazny, Yvonne R. Shea, Cesar A. Arias, Cameron Ashbaugh, Maryam Mahmood, Zelalem Temesgen, Alexander G. Theofiles, Masayuki Nigo, Varsha Moudgal, Karen C. Bloch, Sean G. Kelly, M. Suzanne Whitworth, Ganesh Rao, Cindy J. Whitener, Neema Mafi, Juan Gea-Banacloche, Lawrence C. Kenyon, William R. Miller, Katia Boggian, Andrea Gilbert, Matthew Sincock, Alexandra F. Freeman, John E. Bennett, Rodrigo Hasbun, Constantinos M. Mikelis, Kyung J. Kwon-Chung, Yasmine Belkaid, Gordon D. Brown, Jean K. Lim, Douglas B. Kuhns, Steven M. Holland, Michail S. Lionakis
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 22 (2022)
Subcutaneous phaeohyphomycosis typically affects immunocompetent individuals following traumatic inoculation. Severe or disseminated infection can occur in CARD9 deficiency or after transplantation, but the mechanisms protecting against phaeohyphomyc
Externí odkaz:
https://doaj.org/article/71c653dd808145c48e7e7ce5ab2b01ae
Autor:
A K M Nawshad Hossian, Fatema Tuz Zahra, Sagun Poudel, Camille F. Abshire, Paula Polk, Jone Garai, Jovanny Zabaleta, Constantinos M. Mikelis, George Mattheolabakis
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract This study aims to identify pathway involvement in the development of cisplatin (cis-diamminedichloroplatinum (II); CDDP) resistance in A549 lung cancer (LC) cells by utilizing advanced bioinformatics software. We developed CDDP-resistant A5
Externí odkaz:
https://doaj.org/article/a63862fee7a94aa29623e74a3b9c3709
Autor:
Amber N. Stratman, Olivia M. Farrelly, Constantinos M. Mikelis, Mayumi F. Miller, Zhiyong Wang, Van N. Pham, Andrew E. Davis, Margaret C. Burns, Sofia A. Pezoa, Daniel Castranova, Joseph J. Yano, Tina M. Kilts, George E. Davis, J. Silvio Gutkind, Brant M. Weinstein
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Tumors can overproduce pro-angiogenic ligands overcoming currently approved anti-angiogenic therapies and hindering their success. Here, the authors show that targeting phosphoinositide recycling during tumor angiogenesis harnesses the tumor’s own
Externí odkaz:
https://doaj.org/article/b6ba0e8777294e85b048f9e6ce5693a2
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
Angiogenesis is a key mechanism for tumor growth and metastasis and has been a therapeutic target for anti-cancer treatments. Intensive vascular growth is concomitant with the rapidly proliferating tumor cell population and tumor outgrowth. Current a
Externí odkaz:
https://doaj.org/article/14b8e8afdeb04a79a9e397411df8e806
Publikováno v:
Pharmaceutics, Vol 14, Iss 12, p 2613 (2022)
In the generational evolution of nano-based drug delivery carriers, active targeting has been a major milestone for improved and selective drug accumulation in tissues and cell types beyond the existing passive targeting capabilities. Among the vario
Externí odkaz:
https://doaj.org/article/373a5b114ee440b19fadd825070f974f
Autor:
Behnaz Lahooti, Racheal G. Akwii, Dhavalkumar Patel, Siavash ShahbaziNia, Margarita Lamprou, Mahboubeh Madadi, Thomas J. Abbruscato, Aristotelis Astrinidis, Ulrich Bickel, Abraham Al-Ahmad, Nadezhda A. German, George Mattheolabakis, Constantinos M. Mikelis
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 385:35-49