Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Constantinos G. Broustas"'
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract As a radiation biodosimetry tool, gene expression profiling is being developed using mouse and human peripheral blood models. The impact of dose, dose-rate, and radiation quality has been studied with the goal of predicting radiological tiss
Externí odkaz:
https://doaj.org/article/c6d13f617c18403e8d878e2dccde2a78
Publikováno v:
BMC Genomics, Vol 19, Iss 1, Pp 1-14 (2018)
Abstract Background Radiation exposure due to the detonation of an improvised nuclear device remains a major security concern. Radiation from such a device involves a combination of photons and neutrons. Although photons will make the greater contrib
Externí odkaz:
https://doaj.org/article/18dbf04d120d4a5ea597ba87389f73ed
Autor:
Usha N. Kasid, Robert Clarke, Bruce G. Haffty, Bhaskar V.S. Kallakury, Françoise Seillier-Moiseiwitsch, Bassem R. Haddad, Anne-Michelle Noone, Rebecca Riggins, Christine E. Sheehan, Qifeng Yang, Jeffrey S. Ross, Constantinos G. Broustas
Supplementary Data from The Proapoptotic Molecule BLID Interacts with Bcl-XL and Its Downregulation in Breast Cancer Correlates with Poor Disease-Free and Overall Survival
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3173bbf1183fc5d21ac07306da2868db
https://doi.org/10.1158/1078-0432.22442939
https://doi.org/10.1158/1078-0432.22442939
Autor:
Usha N. Kasid, Robert Clarke, Bruce G. Haffty, Bhaskar V.S. Kallakury, Françoise Seillier-Moiseiwitsch, Bassem R. Haddad, Anne-Michelle Noone, Rebecca Riggins, Christine E. Sheehan, Qifeng Yang, Jeffrey S. Ross, Constantinos G. Broustas
Purpose: BLID is a BH3-like motif containing apoptotic member of the Bcl-2 family of proteins. This study was designed to investigate the mechanism of BLID-induced apoptosis and to assess the significance of BLID expression in breast cancer.Experimen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55e9224948941ca0661412cfe381f045
https://doi.org/10.1158/1078-0432.c.6519560.v1
https://doi.org/10.1158/1078-0432.c.6519560.v1
Blood-based gene expression profiles that can reconstruct radiation exposure are being developed as a practical approach to radiation biodosimetry. However, age and sex could potentially limit the accuracy of the approach. In this study, we determine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33cd1bc980663a00cd5c09bce1f5697c
https://doi.org/10.1101/2022.10.27.514053
https://doi.org/10.1101/2022.10.27.514053
Autor:
Constantinos G. Broustas, Sanjay Mukherjee, Evan L. Pannkuk, Evagelia C. Laiakis, Albert J. Fornace, Sally A. Amundson
Publikováno v:
Radiat Res
Radiation biodosimetry based on transcriptomic analysis of peripheral blood is a valuable tool to detect radiation exposure after a radiological/nuclear event and obtain useful biological information that could predict tissue and organismal injury. H
Autor:
Aiping Zhu, Richard A. Friedman, Kevin M. Hopkins, Howard B. Lieberman, Joshua D. Bernstock, Constantinos G. Broustas
Publikováno v:
Carcinogenesis
Prostate cancer is the second most common type of cancer and the second leading cause of cancer death in American men. RAD9 stabilizes the genome, but prostate cancer cells and tumors often have high quantities of the protein. Reduction of RAD9 level
Autor:
Sunil K Panigrahi, Constantinos G. Broustas, Renu K. Virk, Howard B. Lieberman, Ping Q. Cuiper
Publikováno v:
Cell Signal
Metastatic progression is the key feature of prostate cancer primarily responsible for mortality caused by this disease. RAD9 is an oncogene for prostate cancer, and the encoded protein enhances metastasis-related phenotypes. RAD9 is a transcription
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6eef0a3a053078a2cd26f6ec9729bbd9
https://europepmc.org/articles/PMC8403642/
https://europepmc.org/articles/PMC8403642/
Publikováno v:
Radiation Research. 187:424-432
The way cells respond to DNA damage is important since inefficient repair or misrepair of lesions can have deleterious consequences, including mutation, genomic instability, neurodegenerative disorders, premature aging, cancer or death. Whether damag
Autor:
Constantinos G. Broustas, Renu K. Virk, Howard B. Lieberman, Axel J. Duval, Kunal R. Chaudhary, Richard A. Friedman
Publikováno v:
Oncogene
Radiotherapy is commonly used to treat a variety of solid human tumors, including localized prostate cancer. However, treatment failure often ensues due to tumor intrinsic or acquired radioresistance. Here we find that the MEK5/ERK5 signaling pathway
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af8c8865e7af25e89bfefa6e83cf325e
https://doi.org/10.1101/737080
https://doi.org/10.1101/737080