Zobrazeno 1 - 10
of 82
pro vyhledávání: '"Constantinos G, Neochoritis"'
Publikováno v:
Tetrahedron Green Chem, Vol 3, Iss , Pp 100044- (2024)
Α sustainable access to therapeutics is today imperative. More than ever, synthetic organic chemistry has to embrace all aspects of green chemistry. The utility of multicomponent reactions especially the Ugi reaction is an established approach in dr
Externí odkaz:
https://doaj.org/article/bf4753a7d61147d88ee8c685513e4caf
Autor:
Barbora Waclawiková, Paulo Cesar Telles de Souza, Markus Schwalbe, Constantinos G. Neochoritis, Warner Hoornenborg, Sieger A. Nelemans, Siewert J. Marrink, Sahar El Aidy
Publikováno v:
Gut Microbes, Vol 15, Iss 1 (2023)
ABSTRACTIntestinal microbiota and microbiota-derived metabolites play a key role in regulating the host physiology. Recently, we have identified a gut-bacterial metabolite, namely 5-hydroxyindole, as a potent stimulant of intestinal motility via its
Externí odkaz:
https://doaj.org/article/bfc4e2f6d78e4fee9419d2cb3d2f3e4a
Autor:
Constantinos G. Neochoritis, Maryam Kazemi Miraki, Eman M. M. Abdelraheem, Ewa Surmiak, Tryfon Zarganes-Tzitzikas, Beata Łabuzek, Tad A. Holak, Alexander Dömling
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 15, Iss 1, Pp 513-520 (2019)
Macrocycles were designed to antagonize the protein–protein interaction p53-MDM2 based on the three-finger pharmacophore F19W23L25. The synthesis was accomplished by a rapid, one-pot synthesis of indole-based macrocycles based on Ugi macrocyclizati
Externí odkaz:
https://doaj.org/article/714269d16b8d497eab7b91bf23d416a7
Autor:
Domna Iordanidou, Michael G. Kallitsakis, Marina A. Tzani, Dimitris I. Ioannou, Tryfon Zarganes-Tzitzikas, Constantinos G. Neochoritis, Alexander Dömling, Michael A. Terzidis, Ioannis N. Lykakis
Publikováno v:
Molecules, Vol 27, Iss 14, p 4395 (2022)
The synthesis of 3,4-dihydroquinoxalin-2-ones via the selective reduction of aromatic, multifunctional nitro precursors catalyzed by supported gold nanoparticles is reported. The reaction proceeds through the in situ formation of the corresponding am
Externí odkaz:
https://doaj.org/article/28e2485e8796495bad185d4eb026eb08
Autor:
Domna Iordanidou, Tryfon Zarganes-Tzitzikas, Constantinos G. Neochoritis, Alexander Dömling, Ioannis N. Lykakis
Publikováno v:
ACS Omega, Vol 3, Iss 11, Pp 16005-16013 (2018)
Externí odkaz:
https://doaj.org/article/daf7ee767b62405689b444ad6175e7a6
Publikováno v:
Synlett. 33:1913-1916
α-Metalated isocyanides are a versatile class of compounds that can easily be employed in various transformations, affording tangible libraries for screening campaigns. We report the ring-opening reactions of cyclic anhydrides and lactones with thre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8a22aaf692d070095d97142074d70267
https://doi.org/10.1055/a-1921-0928
https://doi.org/10.1055/a-1921-0928
Autor:
Giasemi K. Angeli, Panagiota Lampiri, Alexander Dömling, Constantinos G. Neochoritis, Pravin Patil, Xiaofang Lei
Publikováno v:
Chemical communications (Cambridge, England), 57(54), 6652-6655. ROYAL SOC CHEMISTRY
Chemical Communications (Cambridge, England)
Chemical Communications (Cambridge, England)
The ubiquitous presence of the indole fragment in natural products and drugs asks for ever novel syntheses. We report an unprecedented mild, two-step synthesis of 2-tetrazolo substituted indoles based on the Ugi-tetrazole reaction combined with an ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98cdebb5d29af216252c50f90110c2ab
https://doi.org/10.1039/d1cc02384e
https://doi.org/10.1039/d1cc02384e
Publikováno v:
Molecular Diversity.
Oxacycles and benzoxepanes are privileged motifs present in a variety of natural products and functional molecules. However, their synthetic access is limited. Here, we demonstrate a rapid synthesis of unprecedented benzoxepanes from readily availabl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52b0edfbc6647262644471daafac6379
https://doi.org/10.1007/s11030-022-10502-9
https://doi.org/10.1007/s11030-022-10502-9
Publikováno v:
Tetrahedron Letters. 120:154453
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3f3f420962f1c75626b7ac9caed03a1c
https://doi.org/10.1016/j.tetlet.2023.154453
https://doi.org/10.1016/j.tetlet.2023.154453
Autor:
Maria Thomaidi, Lida‐Evmorfia Vagiaki, Nikolaos P. Tripolitsiotis, Giasemi K. Angeli, Tryfon Zarganes‐Tzitzikas, Kyriaki Sidiropoulou, Constantinos G. Neochoritis
Publikováno v:
ChemMedChem. 17(15)
Local anesthetics occupy a prime position in clinical medicine as they temporarily relieve the pain by blocking voltage-gated sodium channels. However, limited structural diversity, problems with the efficiency of syntheses and increasing toxicity, m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af131de080976e6ae5ab4762a00b0a6d
https://pubmed.ncbi.nlm.nih.gov/35642621
https://pubmed.ncbi.nlm.nih.gov/35642621