Zobrazeno 1 - 10
of 133
pro vyhledávání: '"Constantinos, Petrovas"'
Autor:
Joana Dias, Giulia Fabozzi, Slim Fourati, Xuejun Chen, Cuiping Liu, David R. Ambrozak, Amy Ransier, Farida Laboune, Jianfei Hu, Wei Shi, Kylie March, Anna A. Maximova, Stephen D. Schmidt, Jakob Samsel, Chloe A. Talana, Keenan Ernste, Sung Hee Ko, Margaret E. Lucas, Pierce E. Radecki, Kristin L. Boswell, Yoshiaki Nishimura, John-Paul Todd, Malcolm A. Martin, Constantinos Petrovas, Eli A. Boritz, Nicole A. Doria-Rose, Daniel C. Douek, Rafick-Pierre Sékaly, Jeffrey D. Lifson, Mangaiarkarasi Asokan, Lucio Gama, John R. Mascola, Amarendra Pegu, Richard A. Koup
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Anti-HIV-1 broadly neutralizing antibodies (bNAbs) have the dual potential of mediating virus neutralization and antiviral effector functions through their Fab and Fc domains, respectively. So far, bNAbs with enhanced Fc effector functions i
Externí odkaz:
https://doaj.org/article/bf19edfc45874c86ab18e09d0df26155
Autor:
Mathilde Foglierini, Pauline Nortier, Rachel Schelling, Rahel R. Winiger, Philippe Jacquet, Sijy O’Dell, Davide Demurtas, Maxmillian Mpina, Omar Lweno, Yannick D. Muller, Constantinos Petrovas, Claudia Daubenberger, Matthieu Perreau, Nicole A. Doria-Rose, Raphael Gottardo, Laurent Perez
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Broadly neutralizing antibodies (bNAbs) are promising candidates for the treatment and prevention of HIV-1 infections. Despite their critical importance, automatic detection of HIV-1 bNAbs from immune repertoires is still lacking. Here, we d
Externí odkaz:
https://doaj.org/article/9d102f79207c417eb04c2d3080c48cb2
Autor:
Spiros Georgakis, Michail Orfanakis, Cloe Brenna, Simon Burgermeister, Perla M. Del Rio Estrada, Mauricio González-Navarro, Fernanda Torres-Ruiz, Gustavo Reyes-Terán, Santiago Avila-Rios, Yara Andrea Luna-Villalobos, Oliver Y. Chén, Giuseppe Pantaleo, Richard A. Koup, Constantinos Petrovas
Publikováno v:
Vaccines, Vol 12, Iss 8, p 912 (2024)
Follicular helper CD4hi T cells (TFH) are a major cellular pool for the maintenance of the HIV reservoir. Therefore, the delineation of the follicular (F)/germinal center (GC) immune landscape will significantly advance our understanding of HIV patho
Externí odkaz:
https://doaj.org/article/e34491b2bac84b12a559ae4ab2f0b6f8
Autor:
Wanwisa Promsote, Ling Xu, Jason Hataye, Giulia Fabozzi, Kylie March, Cassandra G. Almasri, Megan E. DeMouth, Sarah E. Lovelace, Chloe Adrienna Talana, Nicole A. Doria-Rose, Krisha McKee, Sabrina Helmold Hait, Joseph P. Casazza, David Ambrozak, Jochen Beninga, Ercole Rao, Norbert Furtmann, Joerg Birkenfeld, Elizabeth McCarthy, John-Paul Todd, Constantinos Petrovas, Mark Connors, Andrew T. Hebert, Jeremy Beck, Junqing Shen, Bailin Zhang, Mikhail Levit, Ronnie R. Wei, Zhi-yong Yang, Amarendra Pegu, John R. Mascola, Gary J. Nabel, Richard A. Koup
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract Agents that can simultaneously activate latent HIV, increase immune activation and enhance the killing of latently-infected cells represent promising approaches for HIV cure. Here, we develop and evaluate a trispecific antibody (Ab), N6/αCD
Externí odkaz:
https://doaj.org/article/8e5eb98b4e8744a192139410ac1ac511
Autor:
Victor Joo, Constantinos Petrovas, Laurence de Leval, Alessandra Noto, Michel Obeid, Craig Fenwick, Giuseppe Pantaleo
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Therapeutic monoclonal antibodies (mAb) targeting the immune checkpoint inhibitor programmed cell death protein 1 (PD-1) have achieved considerable clinical success in anti-cancer therapy through relieving T cell exhaustion. Blockade of PD-1 interact
Externí odkaz:
https://doaj.org/article/065a7f9cf7cc45818a04a4f87b1fc2c0
Autor:
Benjamin L. Oyler, Jeferson A. Valencia-Dávila, Eirini Moysi, Adam Molyvdas, Kalliopi Ioannidou, Kylie March, David Ambrozak, Laurence De Leval, Giulia Fabozzi, Amina S. Woods, Richard A. Koup, Constantinos Petrovas
Publikováno v:
iScience, Vol 26, Iss 8, Pp 107261- (2023)
Summary: Secondary human lymphoid tissue immune reactions take place in a highly coordinated environment with compartmentalization representing a fundamental feature of this organization. In situ profiling methodologies are indispensable for the unde
Externí odkaz:
https://doaj.org/article/ae7787be0d6b45b3a846fa4f71bcc74c
Autor:
Sakthivel Govindaraj, Hemalatha Babu, Sunil Kannanganat, Monica Vaccari, Constantinos Petrovas, Vijayakumar Velu
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Externí odkaz:
https://doaj.org/article/83b775a9fe944e5a8c9a5dd74ddacae6
Autor:
Margaret H. O’Connor, Roshell Muir, Marita Chakhtoura, Michael Fang, Eirini Moysi, Susan Moir, Alison J. Carey, Alyssa Terk, Carmen N. Nichols, Talibah Metcalf, Constantinos Petrovas, Mark J. Cameron, Virginie Tardif, Elias K. Haddad
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-13 (2021)
Margaret O’Connor et al. report a new Innate Lymphoid Cell population in human tonsils and lymph nodes that inhibit the functional interaction of follicular helper T cells and germinal center B cells. They show that this cell population is expanded
Externí odkaz:
https://doaj.org/article/a866230b1fdc4b2fb508ecc62a24397c
Autor:
Leila Eslamizar, Constantinos Petrovas, David J. Leggat, Kathryn Furr, Michelle L. Lifton, Gail Levine, Steven Ma, Christopher Fletez-Brant, Wesley Hoyland, Madhu Prabhakaran, Sandeep Narpala, Kristin Boswell, Takuya Yamamoto, Hua-Xin Liao, David Pickup, Elizabeth Ramsburg, Laura Sutherland, Adrian McDermott, Mario Roederer, David Montefiori, Richard A. Koup, Barton F. Haynes, Norman L. Letvin, Sampa Santra
Publikováno v:
npj Vaccines, Vol 6, Iss 1, Pp 1-10 (2021)
Abstract The RV144 HIV-1 vaccine trial has been the only clinical trial to date that has shown any degree of efficacy and associated with the presence of vaccine-elicited HIV-1 envelope-specific binding antibody and CD4+ T-cell responses. This trial
Externí odkaz:
https://doaj.org/article/63b38173c836479fba679161167f0413
Autor:
Daniel Kvistad, Suresh Pallikkuth, Tirupataiah Sirupangi, Rajendra Pahwa, Alexander Kizhner, Constantinos Petrovas, Francois Villinger, Savita Pahwa
Publikováno v:
JCI Insight, Vol 6, Iss 20 (2021)
Natural aging and HIV infection are associated with chronic low-grade systemic inflammation, immune senescence, and impaired antibody responses to vaccines such as the influenza (flu) vaccine. We investigated the role of IL-21, a CD4+ T follicular he
Externí odkaz:
https://doaj.org/article/72df68a60d5c4b1eae033ee6f07d30cf