A genome-wide Drosophila epithelial tumorigenesis screen identifies Tetraspanin 29Fb as an evolutionarily conserved suppressor of Ras-driven cancer.

Autor: Tamara Zoranovic, Jan Manent, Lee Willoughby, Ricardo Matos de Simoes, John E La Marca, Sofya Golenkina, Xia Cuiping, Susanne Gruber, Belinda Angjeli, Elisabeth Eva Kanitz, Shane J F Cronin, G Gregory Neely, Andreas Wernitznig, Patrick O Humbert, Kaylene J Simpson, Constantine S Mitsiades, Helena E Richardson, Josef M Penninger

Publikováno v: PLoS Genetics, Vol 14, Iss 10, p e1007688 (2018)

Oncogenic mutations in the small GTPase Ras contribute to ~30% of human cancers. However, Ras mutations alone are insufficient for tumorigenesis, therefore it is paramount to identify cooperating cancer-relevant signaling pathways. We devised an in v

Externí odkaz: https://doaj.org/article/398b05ace50540ebbc5d12234222f441

Microenvironmental influence on pre-clinical activity of polo-like kinase inhibition in multiple myeloma: implications for clinical translation.

Autor: Douglas W McMillin, Jake Delmore, Joseph Negri, Melissa Ooi, Steffen Klippel, Chandrasekhar V Miduturu, Nathanael S Gray, Paul G Richardson, Kenneth C Anderson, Andrew L Kung, Constantine S Mitsiades

Publikováno v: PLoS ONE, Vol 6, Iss 7, p e20226 (2011)

Polo-like kinases (PLKs) play an important role in cell cycle progression, checkpoint control and mitosis. The high mitotic index and chromosomal instability of advanced cancers suggest that PLK inhibitors may be an attractive therapeutic option for

Externí odkaz: https://doaj.org/article/04c02c07f07a4c62af5036b743395d86

Genome-scale functional genomics identify genes preferentially essential for multiple myeloma cells compared to other neoplasias

Autor: Ricardo de Matos Simoes, Ryosuke Shirasaki, Sondra L. Downey-Kopyscinski, Geoffrey M. Matthews, Benjamin G. Barwick, Vikas A. Gupta, Daphné Dupéré-Richer, Shizuka Yamano, Yiguo Hu, Michal Sheffer, Eugen Dhimolea, Olga Dashevsky, Sara Gandolfi, Kazuya Ishiguro, Robin M. Meyers, Jordan G. Bryan, Neekesh V. Dharia, Paul J. Hengeveld, Johanna B. Brüggenthies, Huihui Tang, Andrew J. Aguirre, Quinlan L. Sievers, Benjamin L. Ebert, Brian J. Glassner, Christopher J. Ott, James E. Bradner, Nicholas P. Kwiatkowski, Daniel Auclair, Joan Levy, Jonathan J. Keats, Richard W. J. Groen, Nathanael S. Gray, Aedin C. Culhane, James M. McFarland, Joshua M. Dempster, Jonathan D. Licht, Lawrence H. Boise, William C. Hahn, Francisca Vazquez, Aviad Tsherniak, Constantine S. Mitsiades

Publikováno v: de Matos Simoes, R, Shirasaki, R, Downey-Kopyscinski, S L, Matthews, G M, Barwick, B G, Gupta, V A, Dupéré-Richer, D, Yamano, S, Hu, Y, Sheffer, M, Dhimolea, E, Dashevsky, O, Gandolfi, S, Ishiguro, K, Meyers, R M, Bryan, J G, Dharia, N V, Hengeveld, P J, Brüggenthies, J B, Tang, H, Aguirre, A J, Sievers, Q L, Ebert, B L, Glassner, B J, Ott, C J, Bradner, J E, Kwiatkowski, N P, Auclair, D, Levy, J, Keats, J J, Groen, R W J, Gray, N S, Culhane, A C, McFarland, J M, Dempster, J M, Licht, J D, Boise, L H, Hahn, W C, Vazquez, F, Tsherniak, A & Mitsiades, C S 2023, ' Genome-scale functional genomics identify genes preferentially essential for multiple myeloma cells compared to other neoplasias ', Nature Cancer, vol. 4, no. 5, pp. 754-773 . https://doi.org/10.1038/s43018-023-00550-x
Nature Cancer, 4(5), 754-773. Nature Research

Clinical progress in multiple myeloma (MM), an incurable plasma cell (PC) neoplasia, has been driven by therapies that have limited applications beyond MM/PC neoplasias and do not target specific oncogenic mutations in MM. Instead, these agents targe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c38520e5128234e34753590416d0e64
https://doi.org/10.1038/s43018-023-00550-x

Figure S1 - Figure S8 from Chemotherapy Induces Senescence-Like Resilient Cells Capable of Initiating AML Recurrence

Autor: Ari M. Melnick, Martin Carroll, Christopher E. Mason, Elisabeth M. Paietta, Michael W. Becker, Richard J. D'Andrea, Hartmut Doehner, Constantine S. Mitsiades, Eugen Dhimolea, Kimihito C. Kawabata, Ceyda Durmaz, Christopher R. Chin, Tak C. Lee, Francine E. Garrett-Bakelman, Cem Meydan, Matt Teater, Meng Li, Cihangir Duy

Supplemental Figures

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26f5cfbb31b0403c58a8d2a79717db84
https://doi.org/10.1158/2159-8290.22540768.v1

Table S6 from Chemotherapy Induces Senescence-Like Resilient Cells Capable of Initiating AML Recurrence

Autor: Ari M. Melnick, Martin Carroll, Christopher E. Mason, Elisabeth M. Paietta, Michael W. Becker, Richard J. D'Andrea, Hartmut Doehner, Constantine S. Mitsiades, Eugen Dhimolea, Kimihito C. Kawabata, Ceyda Durmaz, Christopher R. Chin, Tak C. Lee, Francine E. Garrett-Bakelman, Cem Meydan, Matt Teater, Meng Li, Cihangir Duy

Network analysis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdbac20e3461c41b2232a959a17a0481
https://doi.org/10.1158/2159-8290.22540750