Zobrazeno 1 - 10
of 133
pro vyhledávání: '"Constantine D. Mavroudis"'
Autor:
Gerard H. Laurent, ScB, Tiffany S. Ko, PhD, Kobina G. Mensah-Brown, MD, MS, Constantine D. Mavroudis, MD, MSC, MTR, Marin Jacobwitz, CRNP, PhD, Nicolina Ranieri, BSc, Susan C. Nicolson, MD, J. William Gaynor, MD, Wesley B. Baker, PhD, Daniel J. Licht, MD, Shavonne L. Massey, MD, MSCE, Jennifer M. Lynch, MD, PhD
Publikováno v:
JTCVS Open, Vol 16, Iss , Pp 801-809 (2023)
Objectives: Recent research suggests that increased cerebral oxygen use during surgical intervention for neonates with congenital heart disease may play a role in the development of postoperative white matter injury. The objective of this study is to
Externí odkaz:
https://doaj.org/article/4c29f008c2cf4b1d92d84d6f9cd52cfe
Autor:
Jill Hsia, MD, Nicholas S. Abend, MD, MSCE, J. William Gaynor, MD, Jonathan M. Chen, MD, Stephanie Fuller, MD, Katsuhide Maeda, MD, PhD, Constantine D. Mavroudis, MD, MSc, MTR, Muhammad Nuri, MD, Jan Leonard, MSPH, Steve B. Ampah, PhD, Daniel J. Licht, MD, Shavonne L. Massey, MD, MSCE, Maryam Y. Naim, MD, MSCE
Publikováno v:
JTCVS Open, Vol 16, Iss , Pp 771-783 (2023)
Objectives: Historically, our center has primarily used deep hypothermic circulatory arrest, but in recent years some surgeons have selectively used regional cerebral perfusion as an alternative. We aimed to compare the incidence of postoperative ele
Externí odkaz:
https://doaj.org/article/a3dd7e7965cd4bc48730f96c09dd7975
Autor:
Danielle I. Aronowitz, Tracy R. Geoffrion, Sarah Piel, Sarah R. Morton, Jonathan Starr, Richard W. Melchior, Hunter A. Gaudio, Rinat Degani, Nicholas J. Widmann, M. Katie Weeks, Nicolina R. Ranieri, Emilie Benson, Tiffany S. Ko, Daniel J. Licht, Marco Hefti, J. William Gaynor, Todd J. Kilbaugh, Constantine D. Mavroudis
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 10, p 5466 (2024)
Optimal oxygen management during pediatric cardiopulmonary bypass (CPB) is unknown. We previously demonstrated an increase in cortical mitochondrial reactive oxygen species and decreased mitochondrial function after CPB using hyperoxic oxygen managem
Externí odkaz:
https://doaj.org/article/3ac3abee895246b5985bf802bad0cc2c
Autor:
Kalil Shaw, Constantine D. Mavroudis, Tiffany S. Ko, Jharna Jahnavi, Marin Jacobwitz, Nicolina Ranieri, Rodrigo M. Forti, Richard W. Melchior, Wesley B. Baker, Arjun G. Yodh, Daniel J. Licht, Susan C. Nicolson, Jennifer M. Lynch
Publikováno v:
Frontiers in Pediatrics, Vol 11 (2023)
BackgroundSurgical procedures involving the aortic arch present unique challenges to maintaining cerebral perfusion, and optimal neuroprotective strategies to prevent neurological injury during such high-risk procedures are not completely understood.
Externí odkaz:
https://doaj.org/article/94e67cbe43c04745bdfe1432f4e5c1ef
Autor:
Emilie J. Benson, Danielle I. Aronowitz, Rodrigo M. Forti, Alec Lafontant, Nicolina R. Ranieri, Jonathan P. Starr, Richard W. Melchior, Alistair Lewis, Jharna Jahnavi, Jake Breimann, Bohyun Yun, Gerard H. Laurent, Jennifer M. Lynch, Brian R. White, J. William Gaynor, Daniel J. Licht, Arjun G. Yodh, Todd J. Kilbaugh, Constantine D. Mavroudis, Wesley B. Baker, Tiffany S. Ko
Publikováno v:
Metabolites, Vol 13, Iss 11, p 1153 (2023)
Cardiopulmonary bypass (CPB) provides cerebral oxygenation and blood flow (CBF) during neonatal congenital heart surgery, but the impacts of CPB on brain oxygen supply and metabolic demands are generally unknown. To elucidate this physiology, we used
Externí odkaz:
https://doaj.org/article/412899bb1f7d4941a34146ce6a1c8ab8
Autor:
Kumaran Senthil, Marco M. Hefti, Larry N. Singh, Ryan W. Morgan, Constantine D. Mavroudis, Tiffany Ko, Hunter Gaudio, Vinay M. Nadkarni, Johannes Ehinger, Robert A. Berg, Robert M. Sutton, Francis X. McGowan, Todd J. Kilbaugh
Publikováno v:
Resuscitation Plus, Vol 10, Iss , Pp 100243- (2022)
Objective: The effect of cardiac arrest (CA) on cerebral transcriptomics and metabolomics is unknown. We previously demonstrated hemodynamic-directed CPR (HD-CPR) improves survival with favorable neurologic outcomes versus standard CPR (Std-CPR). We
Externí odkaz:
https://doaj.org/article/62fadec4ab90426db8c5b924e25640c7
Autor:
Tiffany S. Ko, Constantine D. Mavroudis, Ryan W. Morgan, Wesley B. Baker, Alexandra M. Marquez, Timothy W. Boorady, Mahima Devarajan, Yuxi Lin, Anna L. Roberts, William P. Landis, Kobina Mensah-Brown, Vinay M. Nadkarni, Robert A. Berg, Robert M. Sutton, Arjun G. Yodh, Daniel J. Licht, Wensheng Guo, Todd J. Kilbaugh
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract Neurologic injury is a leading cause of morbidity and mortality following pediatric cardiac arrest. In this study, we assess the feasibility of quantitative, non-invasive, frequency-domain diffuse optical spectroscopy (FD-DOS) neuromonitorin
Externí odkaz:
https://doaj.org/article/357b300a7e434438a8ef0a890b5f4cb3
Autor:
Constantine D. Mavroudis, Tiffany S. Ko, Ryan W. Morgan, Lindsay E. Volk, William P. Landis, Benjamin Smood, Rui Xiao, Marco Hefti, Timothy W. Boorady, Alexandra Marquez, Michael Karlsson, Daniel J. Licht, Vinay M. Nadkarni, Robert A. Berg, Robert M. Sutton, Todd J. Kilbaugh
Publikováno v:
Critical Care, Vol 24, Iss 1, Pp 1-13 (2020)
Abstract Background Despite controversies, epinephrine remains a mainstay of cardiopulmonary resuscitation (CPR). Recent animal studies have suggested that epinephrine may decrease cerebral blood flow (CBF) and cerebral oxygenation, possibly potentia
Externí odkaz:
https://doaj.org/article/73429063db8242768066239a18d24bff
Autor:
Kumaran Senthil, Ryan W. Morgan, Marco M. Hefti, Michael Karlsson, Andrew J. Lautz, Constantine D. Mavroudis, Tiffany Ko, Vinay M. Nadkarni, Johannes Ehinger, Robert A. Berg, Robert M. Sutton, Francis X. McGowan, Todd J. Kilbaugh
Publikováno v:
Resuscitation Plus, Vol 6, Iss , Pp 100124- (2021)
Objective: Cerebral mitochondrial dysfunction is a key mediator of neurologic injury following cardiac arrest (CA) and is regulated by the balance of fusion and fission (mitochondrial dynamics). Under stress, fission can decrease mitochondrial mass a
Externí odkaz:
https://doaj.org/article/19c14c14f8fc4485b3225576a21474de
Autor:
Tiffany S. Ko, Constantine D. Mavroudis, Emilie J. Benson, Rodrigo M. Forti, Richard W. Melchior, Timothy W. Boorady, Vincent C. Morano, Kobina Mensah-Brown, Yuxi Lin, Danielle Aronowitz, Jonathan P. Starr, Tami M. Rosenthal, Brandon C. Shade, Kellie L. Schiavo, Brian R. White, Jennifer M. Lynch, J. William Gaynor, Daniel J. Licht, Arjun G. Yodh, Wesley B. Baker, Todd J. Kilbaugh
Publikováno v:
Metabolites, Vol 12, Iss 8, p 737 (2022)
Neonates undergoing cardiac surgery involving aortic arch reconstruction are at an increased risk for hypoxic-ischemic brain injury. Deep hypothermia is utilized to help mitigate this risk when periods of circulatory arrest are needed for surgical re
Externí odkaz:
https://doaj.org/article/242bc912356f49dfbb8517af090a3b4d