Zobrazeno 1 - 10
of 58
pro vyhledávání: '"Constantine D Tsoukas"'
Autor:
David M Guimond, Nicholas R Cam, Nupura Hirve, Wei Duan, John D Lambris, Michael Croft, Constantine D Tsoukas
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e63645 (2013)
The inducible T cell kinase (ITK) regulates type 2 (Th2) cytokines that provide defense against certain parasitic and bacterial infections and are involved in the pathogenesis of lung inflammation such as allergic asthma. Activation of ITK requires t
Externí odkaz:
https://doaj.org/article/edf470c0afbc4eea888e37cb6147f104
Autor:
Nupura Hirve, Roman M Levytskyy, Stephanie Rigaud, David M Guimond, Tomasz Zal, Karsten Sauer, Constantine D Tsoukas
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e45158 (2012)
Binding of the membrane phospholipid phosphatidylinositol 3,4,5-trisphosphate (PIP(3)) to the Pleckstrin Homology (PH) domain of the Tec family protein tyrosine kinase, Inducible T cell Kinase (ITK), is critical for the recruitment of the kinase to t
Externí odkaz:
https://doaj.org/article/97cbf54ebbe84f86a9ad66d1ea411332
Autor:
David M. Guimond, John D. Lambris, Juris A. Grasis, Nicholas R. Cam, Krystal Herman, Paola Magotti, Constantine D. Tsoukas
Publikováno v:
Molecular and Cellular Biology. 30:3596-3609
In vitro data have suggested that activation of the inducible T-cell kinase (ITK) requires an interaction with the adaptor protein SLP-76. One means for this interaction involves binding of the ITK SH3 domain to the polyproline-rich (PR) region of SL
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cb326d88d2314eda761fa87aff3c29c
https://doi.org/10.1128/mcb.01657-09
https://doi.org/10.1128/mcb.01657-09
Autor:
Andrew T. Miller, Amy H. Andreotti, Constantine D. Tsoukas, Yina H. Huang, Stephen Soonthornvacharin, Juris A. Grasis, Ruo Xu, Karsten Sauer, Michael P. Cooke
Publikováno v:
Science. 316:886-889
Pleckstrin homology (PH) domain–mediated protein recruitment to cellular membranes is of paramount importance for signal transduction. The recruitment of many PH domains is controlled through production and turnover of their membrane ligand, phosph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4914f505c43bb439e3d09fc61f2de939
https://doi.org/10.1126/science.1138684
https://doi.org/10.1126/science.1138684
Autor:
Caitlin D. Lemke, Miren L. Baroja, Gabriel Criado, Joaquín Madrenas, A. K. M. Nur-ur Rahman, Constantine D. Tsoukas, Stephen S. G. Ferguson, John K. McCormick, Clara Bueno
Publikováno v:
Robarts Immunology and Transplantation Publications
The paradigm to explain antigen-dependent T cell receptor (TCR) signaling is based on the activation of the CD4 or CD8 coreceptor-associated kinase Lck. It is widely assumed that this paradigm is also applicable to signaling by bacterial superantigen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46f1f16540d1500db9a29d0f5664cbc0
https://doi.org/10.1016/j.immuni.2006.04.012
https://doi.org/10.1016/j.immuni.2006.04.012
Publikováno v:
Immunology today. 5(11)
Monoclonal antibodies raised against human T lymphocytes have identified several cell surface structures that are intimately involved in T-cell function. Perhaps the most familiar is the structure labelled T3. First identified as an antigen five year
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43d83f74341bbc33c0f72cf82025e31a
https://pubmed.ncbi.nlm.nih.gov/25290752
https://pubmed.ncbi.nlm.nih.gov/25290752
Publikováno v:
The Journal of Immunology. 163:6006-6013
Expressed in mast and T-cells/inducible T cell tyrosine kinase (Emt/Itk) is a protein tyrosine kinase required for T cell Ag receptor (TCR)-induced activation and development. A physical interaction between Emt/Itk and TCR has not been described prev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::345b72e70ec180079d078912345e65d1
https://doi.org/10.4049/jimmunol.163.11.6006
https://doi.org/10.4049/jimmunol.163.11.6006
Publikováno v:
European Journal of Immunology. 28:1645-1655
We have investigated the role of the hematopoietically expressed G16 GTP-binding protein on T cell activation. We constructed transfectants of Jurkat T cells that express a function-deficient mutant of G alpha 16 predicted to prevent activation of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::209e952d7e91bf774448417e461e3280
https://doi.org/10.1002/(sici)1521-4141(199805)28:05<1645::aid-immu1645>3.0.co
https://doi.org/10.1002/(sici)1521-4141(199805)28:05<1645::aid-immu1645>3.0.co
Autor:
Lie Min, Constantine D. Tsoukas, Roman M. Levytskyy, Nupura Hirve, Amy H. Andreotti, David M. Guimond
Publikováno v:
Journal of Signal Transduction
ITK-SH3-mediated interactions, both with exogenous ligands and via intermolecular self-association with ITK-SH2, have been shown to be important for regulation of ITK activity. The biological significance of these competing SH3 interactions is not co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::306d770860923693abf0cfe0bc033757
Autor:
Joseph A. Hedrick, Debbie Watry, Constantine D. Tsoukas, Patrick T. O'Donnell, John D. Lambris, Catherine Speiser
Publikováno v:
European Journal of Immunology. 22:1123-1131
Epstein-Barr virus (EBV), the causative agent of mononucleosis and several human cancers, infects cells via complement receptor type 2 (CR2, CD21) which also serves as the receptor for the third complement component, C3. Expression of this receptor i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac3f3b80e972d88e82c01f73ff36db05
https://doi.org/10.1002/eji.1830220504
https://doi.org/10.1002/eji.1830220504