Clinical Study on the Melarsoprol-Related Encephalopathic Syndrome: Risk Factors and HLA Association

Autor: Jorge Seixas, Jorge Atouguia, Teófilo Josenando, Gedeão Vatunga, Constantin Miaka Mia Bilenge, Pascal Lutumba, Christian Burri

Publikováno v: Tropical Medicine and Infectious Disease, Vol 5, Iss 1, p 5 (2020)

Melarsoprol administration for the treatment of late-stage human African trypanosomiasis (HAT) is associated with the development of an unpredictable and badly characterized encephalopathic syndrome (ES), probably of immune origin, that kills approxi

Externí odkaz: https://doaj.org/article/94183203fd934f5eb63be8fa25eb7504

Efficacy, Safety, and Dose of Pafuramidine, a New Oral Drug for Treatment of First Stage Sleeping Sickness, in a Phase 2a Clinical Study and Phase 2b Randomized Clinical Studies.

Autor: Christian Burri, Patrick D Yeramian, James L Allen, Ada Merolle, Kazadi Kyanza Serge, Alain Mpanya, Pascal Lutumba, Victor Kande Betu Ku Mesu, Constantin Miaka Mia Bilenge, Jean-Pierre Fina Lubaki, Alfred Mpoo Mpoto, Mark Thompson, Blaise Fungula Munungu, Francisco Manuel, Théophilo Josenando, Sonja C Bernhard, Carol A Olson, Johannes Blum, Richard R Tidwell, Gabriele Pohlig

Publikováno v: PLoS Neglected Tropical Diseases, Vol 10, Iss 2, p e0004362 (2016)

BACKGROUND:Sleeping sickness (human African trypanosomiasis [HAT]) is caused by protozoan parasites and characterized by a chronic progressive course, which may last up to several years before death. We conducted two Phase 2 studies to determine the

Externí odkaz: https://doaj.org/article/85fe4504afb44d6aa8d68789bbb6f651

Clinical study on the melarsoprol-related encephalopathic syndrome: risk factors and HLA association

Autor: Christian Burri, Gedeao Vatunga, Teófilo Josenando, Constantin Miaka Mia Bilenge, Jorge Luís Marques da Silva Atouguia, Pascal Lutumba, Jorge Seixas

Publikováno v: Tropical Medicine and Infectious Disease
Tropical Medicine and Infectious Disease; Volume 5; Issue 1; Pages: 5
Tropical Medicine and Infectious Disease, Vol 5, Iss 1, p 5 (2020)

Melarsoprol administration for the treatment of late-stage human African trypanosomiasis (HAT) is associated with the development of an unpredictable and badly characterized encephalopathic syndrome (ES), probably of immune origin, that kills approxi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aff3de5ca95db2f8385a48f1b0c9cc52
https://edoc.unibas.ch/74213/

Efficacy and safety of pafuramidine versus pentamidine maleate for treatment of first stage sleeping sickness in a randomized, comparator-controlled, international phase 3 clinical trial

Autor: Christian Burri, Patrick Mangoni N’tombe, Richard R. Tidwell, Carol A. Olson, Pierre Nsele Mutantu, José R. Franco, Alain Fukinsia Mintwo, Johannes Blum, Amadeu Dala, Alfred Mpoo Mpoto, Constantin Miaka Mia Bilenge, Stephen Macharia, Augustin Kayeye Munungi, Gabriele Pohlig, Florent Mbo Kuikumbi, Alain Mpanya, Gratias Kambau Manesa Deo, Ndinga Dieyi Dituvanga, Sonja C. Bernhard, Victor Kande Betu Ku Mesu, Jean Pierre Fina Lubaki, Blaise Fungula Munungu

Publikováno v: PLoS Neglected Tropical Diseases, Vol 10, Iss 2, p e0004363 (2016)
PLoS Neglected Tropical Diseases

Background Sleeping sickness (human African trypanosomiasis [HAT]) is a neglected tropical disease with limited treatment options that currently require parenteral administration. In previous studies, orally administered pafuramidine was well tolerat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35e60a4421a5baa6e621690fefdd5db0

Trypanosomiasis Control, Democratic Republic of Congo, 1993–2003

Autor: P. Lutumba, Wim Van der Veken, Marleen Boelaert, Filip Meheus, Constantin Miaka mia Bilenge, J. Declercq, Jo Robays, Victor Kande Betu Ku Mesu, Didier Molisho, Jean Jannin

Publikováno v: Emerging Infectious Diseases, Vol 11, Iss 9, Pp 1382-1388 (2005)
Emerging Infectious Diseases

Efforts to control human trypanosomiasis, which sharply reduced the disease, must be sustained.
In the Democratic Republic of Congo (DRC), human African trypanosomiasis (HAT) reached unprecedented levels in the 1990s. To assess recent trends and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fe6dde2fefe72e6106bb18c068e599b
https://wwwnc.cdc.gov/eid/article/11/9/04-1020_article