Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Constantin Menche"'
Autor:
Asma Ahmed, Cindy Reinhold, Eileen Breunig, Truong San Phan, Lea Dietrich, Feodora Kostadinova, Corinne Urwyler, Verena M. Merk, Mario Noti, Israel Toja da Silva, Konstantin Bode, Fatima Nahle, Anna Pia Plazzo, Julia Koerner, Regula Stuber, Constantin Menche, Eva Karamitopoulou, Henner F. Farin, Kenneth J. Gollob, Thomas Brunner
Publikováno v:
Molecular Oncology, Vol 17, Iss 8, Pp 1545-1566 (2023)
Control of tumour development and growth by the immune system critically defines patient fate and survival. What regulates the escape of colorectal tumours from destruction by the immune system remains currently unclear. Here, we investigated the rol
Externí odkaz:
https://doaj.org/article/e2887ae1833f4172bd9bbea51ee70193
Autor:
Mohammed H. Mosa, Ophélie Nicolle, Sophia Maschalidi, Fernando E. Sepulveda, Aurelien Bidaud-Meynard, Constantin Menche, Birgitta E. Michels, Grégoire Michaux, Geneviève de Saint Basile, Henner F. Farin
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 6, Iss 4, Pp 477-493.e1 (2018)
Background & Aims: Microvillus inclusion disease (MVID) is a congenital intestinal malabsorption disorder caused by defective apical vesicular transport. Existing cellular models do not fully recapitulate this heterogeneous pathology. The aim of this
Externí odkaz:
https://doaj.org/article/ef293e491f7240379703b18ddd4ab05a
Autor:
Henner F. Farin, Florian R. Greten, Tahmineh Darvishi, Adele M. Nicolas, Constantin Menche, Birgitta E. Michels, Mohammed H. Mosa
Supplementary Data Tables S1-S8 - Table S1. Details of all antibodies (A) and primer sequences (B) used in this study, Table S2. Differentially expressed genes of tumor organoids cultured in vitro, Table S3. Differentially expressed genes of FACS-pur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b009e72ca7a9359db6b0af6814f91a9
https://doi.org/10.1158/0008-5472.22426815
https://doi.org/10.1158/0008-5472.22426815
Autor:
Henner F. Farin, Florian R. Greten, Tahmineh Darvishi, Adele M. Nicolas, Constantin Menche, Birgitta E. Michels, Mohammed H. Mosa
In this file we provide additional methods for the described procedures including organoid transduction/transgenesis, biological image processing and image quantification. We provide in-depth information on the RNA sequencing protocol used and descri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50acb911e14f201ceda1921536e994c0
https://doi.org/10.1158/0008-5472.22426812.v1
https://doi.org/10.1158/0008-5472.22426812.v1
Autor:
Henner F. Farin, Florian R. Greten, Tahmineh Darvishi, Adele M. Nicolas, Constantin Menche, Birgitta E. Michels, Mohammed H. Mosa
Figure S1. Generation of engineered tumor organoids, Figure S2. Characterization of Sfrp1-expressing organoids in vitro and upon transplantation, Figure S3. Characterization of APTK organoids upon transplantation, Figure S4. Characterization of Dkk1-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a198a4e9a7d0445a49a6e6ac869d4d1
https://doi.org/10.1158/0008-5472.22426818
https://doi.org/10.1158/0008-5472.22426818
Autor:
Harald Schuhwerk, Constantin Menche, Isabell Armstark, Pooja Gupta, Kathrin Fuchs, Ruthger van Roey, Mohammed H. Mosa, Carol I. Geppert, Stefanie Bärthel, Dieter Saur, Florian R. Greten, Simone Brabletz, Thomas Brabletz, Henner F. Farin, Marc P. Stemmler
The EMT-transcription factor ZEB1 is heterogeneously expressed in tumor cells and in cancer-associated fibroblasts (CAFs) in colorectal cancer (CRC). While ZEB1 in tumor cells regulates metastasis and therapy resistance, its role in CAFs is largely u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::17e29e3e113d6d88894ee754c11b9d04
https://doi.org/10.1101/2023.03.28.534565
https://doi.org/10.1101/2023.03.28.534565
Autor:
Constantin Menche, Henner F. Farin
Publikováno v:
Experimental & Molecular Medicine
Organoid technology allows the expansion of primary epithelial cells from normal and diseased tissues, providing a unique model for human (patho)biology. In a three-dimensional environment, adult stem cells self-organize and differentiate to gain tis
Autor:
Adele M. Nicolas, Birgitta E. Michels, Constantin Menche, Tahmineh Darvishi, Henner F. Farin, Mohammed H. Mosa, Florian R. Greten
Publikováno v:
Cancer Research. 80:5569-5582
Tumor progression is recognized as a result of an evolving cross-talk between tumor cells and their surrounding nontransformed stroma. Although Wnt signaling has been intensively studied in colorectal cancer, it remains unclear whether activity in th
Autor:
Ewelina Czlonka, Khalil Abou-El-Ardat, Birgitta E. Michels, Tahmineh Darvishi, Sebastian Wagner, Barbara I. Streibl, Hind Medyouf, Henner F. Farin, Constantin Menche, Mohammed H. Mosa, Jan Winter, Tianzuo Zhan, Michael Boutros
Publikováno v:
Cell Stem Cell. 26:782-792.e7
Summary Colorectal cancer (CRC) is characterized by prominent genetic and phenotypic heterogeneity between patients. To facilitate high-throughput genetic testing and functional identification of tumor drivers, we developed a platform for pooled CRIS