Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Constantin Heil"'
Autor:
Eva Pigna, Elena Simonazzi, Krizia Sanna, Krzysztof Marian Bernadzki, Tomek Proszynski, Constantin Heil, Daniela Palacios, Sergio Adamo, Viviana Moresi
Publikováno v:
EBioMedicine, Vol 40, Iss , Pp 717-732 (2019)
Background: Histone deacetylase 4 (HDAC4) has been proposed as a target for Amyotrophic Lateral Sclerosis (ALS) because it mediates nerve-skeletal muscle interaction and since its expression in skeletal muscle correlates with the severity of the dise
Externí odkaz:
https://doaj.org/article/4f0df91a0ba54f9ba7cda7a5a676e4d9
Autor:
Constantin Heil
Publikováno v:
Open Biology, Vol 10, Iss 6 (2020)
Externí odkaz:
https://doaj.org/article/d3b94fdaa6304b6d88e3ce91b6aac407
Autor:
Silvia Scaricamazza, Illari Salvatori, Giacomo Giacovazzo, Jean Philippe Loeffler, Frederique Renè, Marco Rosina, Cyril Quessada, Daisy Proietti, Constantin Heil, Simona Rossi, Stefania Battistini, Fabio Giannini, Nila Volpi, Frederik J. Steyn, Shyuan T. Ngo, Elisabetta Ferraro, Luca Madaro, Roberto Coccurello, Cristiana Valle, Alberto Ferri
Publikováno v:
iScience, Vol 23, Iss 5, Pp - (2020)
Summary: Patients with ALS show, in addition to the loss of motor neurons in the spinal cord, brainstem, and cerebral cortex, an abnormal depletion of energy stores alongside hypermetabolism. In this study, we show that bioenergetic defects and muscl
Externí odkaz:
https://doaj.org/article/93e692a5f29146c4b56df3efb45dd920
Autor:
Constantin Heil
Publikováno v:
Open Biology, Vol 9, Iss 1 (2019)
Cerebellar granule cell progenitors (GCPs) undergo proliferation in the post-natal cerebellum that is dependent on sonic hedgehog (SHH) signalling. Deregulated SHH signalling leads to type 2 medulloblastoma (MB). In this work, a novel cell culture pr
Externí odkaz:
https://doaj.org/article/9a3f2131f99541518b7617e918d05297
Autor:
Clarissa Catale, Luisa Lo Iacono, Alessandro Martini, Constantin Heil, Ezia Guatteo, Nicola Biagio Mercuri, Maria Teresa Viscomi, Daniela Palacios, Valeria Carola
Early life stress (ELS) is known to modify trajectories of brain dopaminergic development, but the mechanisms underlying have not been determined. ELS perturbs immune system and microglia reactivity, and inflammation and microglia influence dopaminer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d92a714a10b0622be3ebbb87dbc5cfe
http://hdl.handle.net/11367/104434
http://hdl.handle.net/11367/104434
Autor:
Roberto Coccurello, Fabio Giannini, Constantin Heil, Jean Philippe Loeffler, Stefania Battistini, Illari Salvatori, Marco Rosina, Nila Volpi, Daisy Proietti, Silvia Scaricamazza, Luca Madaro, Giacomo Giacovazzo, Elisabetta Ferraro, Simona Rossi, Frederik J. Steyn, Shyuan T. Ngo, Alberto Ferri, Cristiana Valle, Cyril Quessada, Frédérique René
Publikováno v:
iScience
iScience, 2020, 23 (5), pp.101087. ⟨10.1016/j.isci.2020.101087⟩
iScience, Vol 23, Iss 5, Pp-(2020)
iScience, Elsevier, 2020, 23 (5), pp.101087. ⟨10.1016/j.isci.2020.101087⟩
iScience, 2020, 23 (5), pp.101087. ⟨10.1016/j.isci.2020.101087⟩
iScience, Vol 23, Iss 5, Pp-(2020)
iScience, Elsevier, 2020, 23 (5), pp.101087. ⟨10.1016/j.isci.2020.101087⟩
Summary Patients with ALS show, in addition to the loss of motor neurons in the spinal cord, brainstem, and cerebral cortex, an abnormal depletion of energy stores alongside hypermetabolism. In this study, we show that bioenergetic defects and muscle
Autor:
Shyuan T. Ngo, Elisabetta Ferraro, Fabio Giannini, Luca Madaro, Constantin Heil, Frédérique René, Alberto Ferri, Cristiana Valle, Giacomo Giacovazzo, Stefania Battistini, Nila Volpi, Cyril Quessada, Daisy Proietti, Roberto Coccurello, Frederik J. Steyn, Illari Salvatori, Silvia Scaricamazza, Simona Rossi, Jean Philippe Loeffler
Publikováno v:
SSRN Electronic Journal.
Besides loss of motor neurons in spinal cord, brainstem and cerebral cortex, patients with ALS show an abnormal depletion of energy stores and a parallel hypermetabolism in spite of simultaneous progression of skeletal muscle atrophy. Our results hig