Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Constantin Efthymiopoulos"'
Publikováno v:
Plant Biosystems - An International Journal Dealing with all Aspects of Plant Biology. 134:67-70
A comparative chemometric study of three taxa of the genus Scabiosa L. s. lato (Dipsacaceae) from Greece, treated so far as separate genera by some authors and as separate sections of a single genus by others, was carried out. The HPLC chemical finge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d52fc7bb6223572c1459806be49a7bed
https://doi.org/10.1080/11263500012331350365
https://doi.org/10.1080/11263500012331350365
Publikováno v:
Clinical Pharmacokinetics. 36:1-11
The objective of these studies was to examine the clinical pharmacokinetics and safety of zanamivir, an influenza A and B virus neuraminidase inhibitor, when administered to healthy volunteers.The safety, tolerability and pharmacokinetics of zanamivi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f0b3a7f07ab0f64ca8da8f21e1a5ca9
https://doi.org/10.2165/00003088-199936001-00001
https://doi.org/10.2165/00003088-199936001-00001
Autor:
Jennifer B. Dressman, Christos Reppas, Eric Galia, Eleftheria Nicolaides, Constantin Efthymiopoulos
Publikováno v:
Pharmaceutical Research. 16:1876-1882
Purpose. To assess the usefulness of biorelevant dissolution tests in predicting food and formulation effects on the absorption of four poorly soluble, lipophilic drugs.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b3d448f0c00c42d092d93284586a805d
https://doi.org/10.1023/a:1018959511323
https://doi.org/10.1023/a:1018959511323
Publikováno v:
Scopus-Elsevier
Zanamivir is eliminated almost exclusively by renal excretion. This study evaluated the effect of renal impairment on the pharmacokinetics of intravenous zanamivir.This open-label study compared individuals with mild/moderate or severe renal impairme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b91a98753fff64f073f0524c3b7691b
https://doi.org/10.2165/00003088-199936001-00002
https://doi.org/10.2165/00003088-199936001-00002
Publikováno v:
Journal of Pharmacokinetics and Biopharmaceutics. 25:149-167
Allometric scaling is an empirical examination of the relationships between the pharmacokinetic parameters and size (usually body weight), but it can also involve brain weight for metabolized drug. Through all species, the protein binding of sumatrip
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5374946d9d33ef9908883eab8d99656e
https://doi.org/10.1023/a:1025728028890
https://doi.org/10.1023/a:1025728028890
Publikováno v:
Clinical Pharmacokinetics. 33:39-46
Two phase I trials, each involving 16 healthy adult volunteers, were performed to investigate possible interactions between grepafloxacin and theophylline or warfarin. In the theophylline study, grepafloxacin 600 mg was administered once daily for 10
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::128920d0466eb41979bad76f9a2f450a
https://doi.org/10.2165/00003088-199700331-00008
https://doi.org/10.2165/00003088-199700331-00008
Autor:
Nathan M. Bass, Steven L. Bramer, Allan Maroli, Erika Wolfe, John F. Flaherty, Constantin Efthymiopoulos, Kenneth A. Somberg
Publikováno v:
Clinical Pharmacokinetics. 33:25-31
The pharmacokinetics of grepafloxacin, a new broad spectrum fluoroquinolone antibiotic, were studied in 2 trials involving 14 healthy volunteers, 10 individuals with mild (Child-Pugh Class A) impairment of liver function, and 12 with moderate (Child-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7177dfde7d8705816e5e167ee2cdc1e7
https://doi.org/10.2165/00003088-199700331-00006
https://doi.org/10.2165/00003088-199700331-00006
Publikováno v:
Clinical Pharmacokinetics. 33:1-8
The pharmacokinetics of grepafloxacin in healthy male subjects following single oral administration of doses ranging from 200 to 1200 mg, and following repeated oral administration of 400 and 800 mg doses are reported. Plasma levels of grepafloxacin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83dc7b394ecc29c2a8d48216dd38b372
https://doi.org/10.2165/00003088-199700331-00003
https://doi.org/10.2165/00003088-199700331-00003
Publikováno v:
Clinical Pharmacokinetics. 33:9-17
The effects of age and gender on the pharmacokinetics of the oral fluoroquinolone grepafloxacin were examined in 48 healthy middle-aged and elderly individuals, of whom half were male and half were female. Participants were stratified into 4 groups (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d02e1affd799af4099f727d3f63b90a3
https://doi.org/10.2165/00003088-199700331-00004
https://doi.org/10.2165/00003088-199700331-00004
Publikováno v:
Clinical Drug Investigation. 9:150-155
The objective of this study was to investigate the presence of stereoselective processes in the pharmacokinetics and metabolism of tertatolol in humans, using urinary excretion data. Six healthy male volunteers were given single 5mg oral doses of (+,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7a582861192a6458469573fc5caa9b20
https://doi.org/10.2165/00044011-199509030-00003
https://doi.org/10.2165/00044011-199509030-00003