Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Constantin Bode"'
Evaluating Sphingosine and its Analogues as Potential Alternatives for Aggressive Lymphoma Treatment
Publikováno v:
Cellular Physiology and Biochemistry, Vol 34, Iss 5, Pp 1686-1700 (2014)
Background: Ceramide (Cer) and sphingosine (Sph) interfere with critical cellular functions relevant for cancer progression and cell survival. While Cer has already been investigated as a potential drug target for lymphoma treatment, information abou
Externí odkaz:
https://doaj.org/article/b541d67234d14d0bad2d9b81d1b25201
Evaluating Sphingosine and its Analogues as Potential Alternatives for Aggressive Lymphoma Treatment
Publikováno v:
Cellular Physiology and Biochemistry, Vol 34, Iss 5, Pp 1686-1700 (2014)
Background: Ceramide (Cer) and sphingosine (Sph) interfere with critical cellular functions relevant for cancer progression and cell survival. While Cer has already been investigated as a potential drug target for lymphoma treatment, information abou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dea39f2b04459bf7dcc181b02529e29e
https://doi.org/10.1159/000366370
https://doi.org/10.1159/000366370
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 328:963-969
The immunomodulator fingolimod (FTY720) induces lymphopenia by inhibiting lymphocyte egress from thymus and secondary lymphoid organs (SLOs). It is phosphorylated mainly by sphingosine kinase (SK) 2 in vivo. FTY720-phosphate (FTY-P) activated and rap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62a99fa8caba8aa03b02be1e11e56e1c
https://doi.org/10.1124/jpet.108.148163
https://doi.org/10.1124/jpet.108.148163
Autor:
Constantin, Bode, Markus H, Gräler
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 874
Liquid chromatography coupled to tandem mass spectrometry has evolved as the method of choice for the detection of sphingolipid metabolites due to its high sensitivity and superior specificity compared to other methodological approaches. Here, we des
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::79e7a129ed25288d716b408768c518c6
https://pubmed.ncbi.nlm.nih.gov/22528437
https://pubmed.ncbi.nlm.nih.gov/22528437
Autor:
Constantin Bode, Markus H. Gräler
Publikováno v:
Methods in Molecular Biology ISBN: 9781617797996
Liquid chromatography coupled to tandem mass spectrometry has evolved as the method of choice for the detection of sphingolipid metabolites due to its high sensitivity and superior specificity compared to other methodological approaches. Here, we des
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::638b2f36bbf2af411eef4e801eacc32e
https://doi.org/10.1007/978-1-61779-800-9_3
https://doi.org/10.1007/978-1-61779-800-9_3
Autor:
Constantin Bode, Markus H. Gräler
Publikováno v:
Archivum immunologiae et therapiae experimentalis. 60(1)
It is well established that the lysophospholipid and signalling molecule sphingosine 1-phosphate (S1P) has many important functions in immune surveillance. S1P is produced from sphingosine by two distinct sphingosine kinases, SphK1 and SphK2, and act
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c42b575f8a5ff439dabc893f88236788
https://pubmed.ncbi.nlm.nih.gov/22159476
https://pubmed.ncbi.nlm.nih.gov/22159476
Autor:
Bodo Levkau, Susann Lucke, Karin von Wnuck Lipinski, Markus H. Gräler, Gerd Heusch, Constantin Bode, Petra Keul
Rationale: The role of sphingosine-1-phosphate (S1P) and its receptors in the pathogenesis of atherosclerosis has not been investigated. Objective: We hypothesized that the S1P receptor 3 (S1P 3 ) plays a causal role in the pathogenesis of atheroscle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c18233aeae1cce1e698cc1639ad80e21
https://www.ncbi.nlm.nih.gov/pubmed/21164103
https://www.ncbi.nlm.nih.gov/pubmed/21164103
Autor:
Thomas Budde, Bodo Levkau, Katherine Sattler, Miriam Elter-Schulz, Constantin Bode, Raimund Erbel, Şehriban Elbasan, Markus H. Gräler, Petra Keul, Gerd Heusch, Martina Bröcker-Preuss
Publikováno v:
Basic research in cardiology. 105(6)
High-density lipoproteins (HDL) are the major plasma carriers for sphingosine 1-phosphate (S1P) in healthy individuals, but their S1P content is unknown for patients with coronary artery disease (CAD). The aim of the study was to determine whether th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d50fc1abd1ec9a7b16d5e92c282660bb
https://pubmed.ncbi.nlm.nih.gov/20652276
https://pubmed.ncbi.nlm.nih.gov/20652276
Autor:
Manju Nagarajan, Markus H. Gräler, Sven-Christian Sensken, Ulrike Peest, Constantin Bode, Oliver Pabst
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 184(8)
Sphingosine kinases (SKs) 1 and 2 produce high concentrations of sphingosine 1-phosphate (S1P) in blood and lymph. In contrast, S1P concentrations in lymphoid tissues are kept low by the S1P-degrading activity of the S1P-lyase. These differences in S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a9dca13ea546448fe5bf342f8a098fb
https://pubmed.ncbi.nlm.nih.gov/20220090
https://pubmed.ncbi.nlm.nih.gov/20220090
Autor:
S. Elbasan, Martina Bröcker-Preuss, Constantin Bode, Katherine Sattler, Miriam Elter-Schulz, Raimund Erbel, Petra Keul, Gerd Heusch, Markus H. Gräler, Thomas Budde, Bodo Levkau
Publikováno v:
Atherosclerosis Supplements. 11:216
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf59bb06c8033dcccc6992cb82d58c3a
https://doi.org/10.1016/s1567-5688(10)71028-x
https://doi.org/10.1016/s1567-5688(10)71028-x