Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Constantia E. Kast"'
Publikováno v:
European Journal of Pharmaceutics and Biopharmaceutics. 55:185-190
The aim of this study was to evaluate the viscoelastic properties of chitosan-thioglycolic acid conjugates with different amounts of thiol groups immobilized on the polymer. The modification of chitosan was achieved via the covalent attachment of thi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea9664f17a63c2e9bfc11e05f153bacd
https://doi.org/10.1016/s0939-6411(02)00162-5
https://doi.org/10.1016/s0939-6411(02)00162-5
Publikováno v:
Pharmaceutical Research. 20:931-936
Purpose. It was the purpose of this study to develop a new oral drug delivery system for low molecular weight heparin (LMWH) providing an improved bioavailability and a prolonged therapeutic effect.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bb4db71691439793683510d19a5f2a20
https://doi.org/10.1023/a:1023803706746
https://doi.org/10.1023/a:1023803706746
Publikováno v:
Pharmaceutical Research. 19:602-608
Purpose. To verify or refute the mechanism of permeation enhancement with thiolated polymers via GSH by the use of NaFlu as marker for the paracellular permeation.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8c62003eebc034293dcad3cc7df4ff1e
https://doi.org/10.1023/a:1015345827091
https://doi.org/10.1023/a:1015345827091
Publikováno v:
Biomaterials. 22:2345-2352
The aim of this study was to improve mucoadhesive properties of chitosan by the covalent attachment of thiol moieties to this cationic polymer. Mediated by a carbodiimide, thioglycolic acid (TGA) was covalently attached to chitosan. This was achieved
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdd5b2f385c420b9e5fb37ec65050661
https://doi.org/10.1016/s0142-9612(00)00421-x
https://doi.org/10.1016/s0142-9612(00)00421-x
Publikováno v:
Pharmaceutical research. 20(12)
Purpose. To develop and evaluate an oral delivery system for salmon calcitonin. Methods. 2-Iminothiolane was covalently bound to chitosan in order to improve the mucoadhesive and cohesive properties of the polymer. The resulting chitosan-TBA conjugat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f2e5339f4820daa813048fe2b3b988e
https://pubmed.ncbi.nlm.nih.gov/14725364
https://pubmed.ncbi.nlm.nih.gov/14725364
Publikováno v:
Journal of controlled release : official journal of the Controlled Release Society. 93(2)
Thiolated polymers (= thiomers) in combination with reduced glutathione (GSH) were shown to improve the uptake of hydrophilic macromolecules from the GI tract. The mechanism responsible for this permeation enhancing effect seems to be based on the th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00201397c506525ecbfcfff6314d0fab
https://pubmed.ncbi.nlm.nih.gov/14636716
https://pubmed.ncbi.nlm.nih.gov/14636716
Publikováno v:
Pharmaceutical research. 20(6)
It was the purpose of this study to develop a new oral drug delivery system for low molecular weight heparin (LMWH) providing an improved bioavailability and a prolonged therapeutic effect.The permeation enhancing polycarbophil-cysteine conjugate (PC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::62f14fa6e2f4e839b65b03896dcf3c17
https://pubmed.ncbi.nlm.nih.gov/12817900
https://pubmed.ncbi.nlm.nih.gov/12817900
Publikováno v:
International journal of pharmaceutics. 256(1-2)
It was the aim of this study to evaluate chitosan-thioglycolic acid (chitosan-TGA) conjugate as scaffold material in tissue engineering. Chitosan was modified by the introduction of thiol groups. Briefly, TGA was introduced to chitosan via amide bond
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d18f34a678a9751f026f70d1fed91d0
https://pubmed.ncbi.nlm.nih.gov/12695025
https://pubmed.ncbi.nlm.nih.gov/12695025
Publikováno v:
Pharmaceutical research. 19(5)
To verify or refute the mechanism of permeation enhancement with thiolated polymers via GSH by the use of NaFlu as marker for the paracellular permeation.The capability of 0.5% polycarbophil cysteine conjugate (PCP-Cys) to reduce 0.02% oxidized gluta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::57de7d783f6f8d6dec640606574a4490
https://pubmed.ncbi.nlm.nih.gov/12069161
https://pubmed.ncbi.nlm.nih.gov/12069161
Publikováno v:
Journal of controlled release : official journal of the Controlled Release Society. 81(3)
It was the purpose of this study to design and evaluate a new bioadhesive vaginal drug delivery system for clotrimazole. Chitosan, a cationic biopolymer derived by deacetylation of chitin, was modified by the introduction of thioglycolic acid (TGA).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e396236f5336ff1a6947b2682481c56
https://pubmed.ncbi.nlm.nih.gov/12044573
https://pubmed.ncbi.nlm.nih.gov/12044573