Výsledky vyhledávání - "Constantí Seira"

Akademický článek

Structural and functional properties of Antarctic fish cytoglobins-1: Cold-reactivity in multi-ligand reactions

Autor: Daniela Giordano, Alessandra Pesce, Stijn Vermeylen, Stefania Abbruzzetti, Marco Nardini, Francesco Marchesani, Herald Berghmans, Constantí Seira, Stefano Bruno, F. Javier Luque, Guido di Prisco, Paolo Ascenzi, Sylvia Dewilde, Martino Bolognesi, Cristiano Viappiani, Cinzia Verde

Publikováno v: Computational and Structural Biotechnology Journal, Vol 18, Iss , Pp 2132-2144 (2020)

While the functions of the recently discovered cytoglobin, ubiquitously expressed in vertebrate tissues, remain uncertain, Antarctic fish provide unparalleled models to study novel protein traits that may arise from cold adaptation. We report here th

Externí odkaz: https://doaj.org/article/43960febc23f463b9d52a49ef7979594

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Structural and functional properties of Antarctic fish cytoglobins-1: Cold-reactivity in multi-ligand reactions

Autor: Herald Berghmans, Paolo Ascenzi, Marco Nardini, Cinzia Verde, Daniela Giordano, Francesco Marchesani, Stijn Vermeylen, Stefania Abbruzzetti, Martino Bolognesi, Cristiano Viappiani, Constantí Seira, Guido di Prisco, Sylvia Dewilde, Alessandra Pesce, Stefano Bruno, F. Javier Luque

Publikováno v: Computational and Structural Biotechnology Journal 18 (2020): 2132–2144. doi:10.1016/j.csbj.2020.08.007
info:cnr-pdr/source/autori:Giordano D.; Pesce A.; Vermeylen S.; Abbruzzetti S.; Nardini M.; Marchesani F.; Berghmans H.; Seira C.; Bruno S.; Javier Luque F.; di Prisco G.; Ascenzi P.; Dewilde S.; Bolognesi M.; Viappiani C.; Verde C./titolo:Structural and functional properties of Antarctic fish cytoglobins-1: Cold-reactivity in multi-ligand reactions/doi:10.1016%2Fj.csbj.2020.08.007/rivista:Computational and Structural Biotechnology Journal/anno:2020/pagina_da:2132/pagina_a:2144/intervallo_pagine:2132–2144/volume:18
Computational and Structural Biotechnology Journal
Dipòsit Digital de la UB
Universidad de Barcelona
'Computational and Structural Biotechnology Journal ', vol: 18, pages: 2132-2144 (2020)
Computational and Structural Biotechnology Journal, Vol 18, Iss, Pp 2132-2144 (2020)

Graphical abstract 1These authors contributed equally as First Author.
While the functions of the recently discovered cytoglobin, ubiquitously expressed in vertebrate tissues, remain uncertain, Antarctic fish provide unparalleled models to study

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af750df4e2640ee580dfff3ddf04032f
http://www.cnr.it/prodotto/i/433166

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Design, synthesis and in vivo study of novel pyrrolidine-based 11β-HSD1 inhibitors for age-related cognitive dysfunction

Autor: Constantí Seira, Axel Bidon-Chanal, Margaret Binnie, Andrew McBride, Christian Griñán-Ferré, Santiago Vázquez, F. Javier Luque, Mercè Pallàs, Scott P. Webster, Rosana Leiva, Belén Pérez, Elena Valverde

Publikováno v: Leiva, R, Griñan-Ferré, C, Seira, C, Valverde, E, McBride, A, Binnie, M, Pérez, B, Luque, F J, Pallàs, M, Bidon-Chanal, A, Webster, S P & Vázquez, S 2017, ' Design, synthesis and in vivo study of novel pyrrolidine-based 11β-HSD1 inhibitors for age-related cognitive dysfunction ', European Journal of Medicinal Chemistry, vol. 139, pp. 412-428 . https://doi.org/10.1016/j.ejmech.2017.08.003

Recent findings suggest that treatment with 11β-HSD1 inhibitors provides a novel approach to deal with age-related cognitive dysfunctions, including Alzheimer's disease. In this work we report potent 11β-HSD1 inhibitors featuring unexplored pyrroli

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea0330603d86713962b6a2902691c08f
https://doi.org/10.1016/j.ejmech.2017.08.003

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Searching for novel applications of the benzohomoadamantane scaffold in medicinal chemistry: Synthesis of novel 11β-HSD1 inhibitors

Autor: Scott P. Webster, Andrew McBride, Constantí Seira, Axel Bidon-Chanal, Margaret Binnie, Elena Valverde, Santiago Vázquez, F. Javier Luque

Publikováno v: Bioorganic & Medicinal Chemistry. 23:7607-7617

The structural and physicochemical properties of the adamantane nucleus account for its use as a chemical scaffold in multiple drugs. In the last years, we have developed new polycyclic scaffolds as surrogates of the adamantane group with encouraging

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e117d923c680f8323c26e9bf4a543dbc
https://doi.org/10.1016/j.bmc.2015.11.004

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Structural Plasticity in Globins

Autor: Constantí Seira, Francisco J. Luque, Luciana Capece, Darío A. Estrin, Axel Bidon-Chanal, Carolina Estarellas

Globins are a family of proteins characterized by the presence of the heme prosthetic group and involved in variety of biological functions in the cell. Due to their biological relevance and widespread distribution in all kingdoms of life, intense re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::87ce747be663d75722bd8d6c52bc52a2
https://doi.org/10.1016/bs.apcsb.2016.07.002

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Novel 11β-HSD1 inhibitors:C-1 versus C-2 substitution and effect of the introduction of an oxygen atom in the adamantane scaffold

Autor: Rosana Leiva, Constantí Seira, Scott P. Webster, Santiago Vázquez, F. Javier Luque, Axel Bidon-Chanal, Margaret Binnie, Andrew McBride

Publikováno v: Leiva, R, Seira, C, McBride, A, Binnie, M, Luque, F J, Bidon-Chanal, A, Webster, S P & Vázquez, S 2015, ' Novel 11β-HSD1 inhibitors : C-1 versus C-2 substitution and effect of the introduction of an oxygen atom in the adamantane scaffold ', Bioorganic & Medicinal Chemistry Letters, vol. 25, no. 19, pp. 4250-3 . https://doi.org/10.1016/j.bmcl.2015.07.097
Recercat. Dipósit de la Recerca de Catalunya
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Dipòsit Digital de la UB
Universidad de Barcelona

The adamantane scaffold is found in several marketed drugs and in many investigational 11β-HSD1 inhibitors. Interestingly, all the clinically approved adamantane derivatives are C-1 substituted. We demonstrate that, in a series of paired adamantane

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef8ef9c1195bea804506d3545fc6cb37
https://www.pure.ed.ac.uk/ws/files/21607010/BMCL_D_15_01081.docx

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Understanding the kinetics of ligand binding to globins with molecular dynamics simulations: the necessity of multiple state models

Autor: Constantí Seira Castan, Carolina Martín, F. Javier Luque Garriga, Axel Bidon-Chanal Badia

Publikováno v: Drug discovery today. Technologies. 17

Residue conformational changes and internal cavity migration processes play a key role in regulating the kinetics of ligand migration and binding events in globins. Molecular dynamics simulations have demonstrated their value in the study of these pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::822e7beea4d9d01eadd3b7e4d453e71b
https://pubmed.ncbi.nlm.nih.gov/26724333

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