Zobrazeno 1 - 10
of 184
pro vyhledávání: '"Constance R, Chu"'
Autor:
Tapash Jay Sarkar, Marco Quarta, Shravani Mukherjee, Alex Colville, Patrick Paine, Linda Doan, Christopher M. Tran, Constance R. Chu, Steve Horvath, Lei S. Qi, Nidhi Bhutani, Thomas A. Rando, Vittorio Sebastiano
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Aging involves gradual loss of tissue function, and transcription factor (TF) expression can ameliorate this in progeroid mice. Here the authors show that transient TF expression reverses age-associated epigenetic marks, inflammatory profiles and res
Externí odkaz:
https://doaj.org/article/b88ee3f2918443da9a944c8371cd034e
Autor:
Thomas P. Andriacchi, Timothy M. Griffin, Richard F. Loeser, Jr., Constance R. Chu, Ewa M. Roos, Gillian A. Hawker, Jennifer C. Erhart-Hledik, Arielle G. Fischer
Publikováno v:
Osteoarthritis and Cartilage Open, Vol 2, Iss 1, Pp 100026- (2020)
Summary: Objective: To stimulate future research directions that seek solutions for osteoarthritis (OA) at the interface between diverse disciplines and address osteoarthritis (OA) as a serious disease with a complexity that has presented a barrier t
Externí odkaz:
https://doaj.org/article/4a73644692c74f389775fbfdd80748e6
Publikováno v:
Stem Cell Research & Therapy, Vol 8, Iss 1, Pp 1-11 (2017)
Abstract Background Induced pluripotent stem cells (iPSC) provide an unlimited patient-specific cell source for regenerative medicine. Adult cells have had limited success in cartilage repair, but juvenile chondrocytes (from donors younger than 13 ye
Externí odkaz:
https://doaj.org/article/d57b433f82f446d2b972dcb9390a02cb
Autor:
Qian Wang, Christin M Lepus, Harini Raghu, Laurent L Reber, Mindy M Tsai, Heidi H Wong, Ericka von Kaeppler, Nithya Lingampalli, Michelle S Bloom, Nick Hu, Eileen E Elliott, Francesca Oliviero, Leonardo Punzi, Nicholas J Giori, Stuart B Goodman, Constance R Chu, Jeremy Sokolove, Yoshihiro Fukuoka, Lawrence B Schwartz, Stephen J Galli, William H Robinson
Publikováno v:
eLife, Vol 8 (2019)
Osteoarthritis is characterized by articular cartilage breakdown, and emerging evidence suggests that dysregulated innate immunity is likely involved. Here, we performed proteomic, transcriptomic, and electron microscopic analyses to demonstrate that
Externí odkaz:
https://doaj.org/article/a7082ff767514c069f8232e435419a7c
Autor:
Mamta Singla, Michela Bruschi, Nidhi Bhutani, Pranay Agarwal, Constance R. Chu, Fiorella C. Grandi, Neety Sahu
Publikováno v:
Tissue Eng Part A
Mesenchymal stromal cells (MSCs) have been widely investigated for their regenerative capacity, anti-inflammatory properties and beneficial immunomodulatory effects across multiple clinical indications. Nevertheless, their widespread clinical utiliza
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2136516d50205a5c36cc7e6c30c771b
https://doi.org/10.1089/ten.tea.2021.0172
https://doi.org/10.1089/ten.tea.2021.0172
Autor:
Daniel W. Hogan, M. Benjamin Burch, Joseph M. Rund, Derek W. Geeslin, Richard Ma, Aaron F. Gray, Constance R. Chu, Taylor E. Ray, W. Michael Pullen, Seth L. Sherman
Publikováno v:
Arthroscopy, Sports Medicine, and Rehabilitation. 4:e417-e424
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7f90ff55e0d3a1264682204c940423a8
https://doi.org/10.1016/j.asmr.2021.10.019
https://doi.org/10.1016/j.asmr.2021.10.019
Autor:
Constance R. Chu
Publikováno v:
Journal of Orthopaedic Research. 40:55-64
Anterior cruciate ligament (ACL) reconstruction is successful at restoring stability to return ACL injured patients to high demand work, sports, and recreational activities. The development of post-traumatic osteoarthritis (OA) in roughly half of pat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcbf9214eb8cf71e3d458f99466618b2
https://doi.org/10.1002/jor.25145
https://doi.org/10.1002/jor.25145
Autor:
Constance R. Chu, Thomas P. Andriacchi, Jessica L. Asay, Jennifer C. Erhart-Hledik, Gordhan B. Mahtani
Publikováno v:
Journal of Orthopaedic Research. 40:129-137
Disruptions in knee biomechanics during walking following anterior cruciate ligament (ACL) injury have been suggested to lead to the development of premature knee osteoarthritis (OA) and to be potential markers of OA risk and targets for intervention
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ae2499bf835c3fe57bda18b948ff410
https://doi.org/10.1002/jor.25025
https://doi.org/10.1002/jor.25025
Autor:
Kyle R. Sochacki, Seth L. Sherman, Geoffrey D. Abrams, Marc R. Safran, Kunal Varshneya, Jacob G. Calcei, Joseph Donahue, Constance R. Chu
Publikováno v:
Cartilage
Objective To compare (1) the reoperation rates, (2) risk factors for reoperation, (3) 30-day complication rates, and (4) cost differences between autologous chondrocyte implantation (ACI) and osteochondral allograft transplantation (OCA) of the knee
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e313556f3826c7e9bbf1727d6501283d
https://doi.org/10.1177/1947603520967065
https://doi.org/10.1177/1947603520967065
Autor:
Daniel W. Hogan, M. Benjamin Burch, Joseph M. Rund, Derek W. Geeslin, Richard Ma, Aaron F. Gray, Constance R. Chu, Taylor E. Ray, W. Michael Pullen, Seth L. Sherman
Publikováno v:
Arthroscopy : the journal of arthroscopicrelated surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association. 38(6)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e66de70b7fd0121e4d6b7397d762c0ab
https://pubmed.ncbi.nlm.nih.gov/35660172
https://pubmed.ncbi.nlm.nih.gov/35660172