Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Constance O. Asher"'
Autor:
Michael P. Kozar, Xiannu Jin, Brandon S. Pybus, Victor Melendez, V. Collazo, Raul Olmeda, Constance O. Asher, N. Matlock, Thu Lan Luong, Dustin Carroll, Jason C. Sousa, Larry A. Walker, T. Logan, Sean R. Marcsisin
Publikováno v:
European journal of drug metabolism and pharmacokinetics. 39(2)
The 8-aminoquinoline drug primaquine (PQ) is currently the only drug in use against the persistent malaria caused by the hypnozoite-forming strains P. vivax and P. ovale. However, despite decades of research, its complete metabolic profile is still p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bc783be128026a981adf008b3fbacff
https://pubmed.ncbi.nlm.nih.gov/23797843
https://pubmed.ncbi.nlm.nih.gov/23797843
Autor:
Lisa Xie, Constance O. Asher, ThuLan Luong, Qigui Li, Daniel A. Nichols, Clare E. Gutteridge, Gettayacamin Montip, Michael P. Kozar, Sean M. Curtis, Darshan S. Thota, Jing Zhang, Victor Melendez, Lucia Gerena
Publikováno v:
Pharmacology. 87(1-2)
4′-n-Butoxy-2,4-dimethoxy-chalcone (MBC) has been described as protecting mice from an otherwise lethal infection with Plasmodium yoelii when dosed orally at 50 mg/kg/dose, daily for 5 days. In contrast, we found that oral dosing of MBC at 640 mg/k
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd0f27818cc4d2a5134e9748ab4ca273
https://pubmed.ncbi.nlm.nih.gov/21282967
https://pubmed.ncbi.nlm.nih.gov/21282967
Autor:
Jason C. Sousa, Kirsten S. Smith, Michael P. Kozar, Damaris S. Diaz, David P. Jacobus, Constance O. Asher, Donald R. Skillman, Todd W Shearer, Guy A. Schiehser, Wilbur K. Milhous
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 36(2)
Phenoxypropoxybiguanides, such as PS-15, are antimalarial prodrugs analogous to the relationship of proguanil and its active metabolite cycloguanil. Unlike cycloguanil, however, WR99210, the active metabolite of PS-15, has retained in vitro potency a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bedd0fb04d9c0dae58ca10cc0cf9ba02
https://pubmed.ncbi.nlm.nih.gov/18006651
https://pubmed.ncbi.nlm.nih.gov/18006651
Autor:
Kirsten S. Smith, Lucia Gerena, Charles A. DiTusa, Daniel A. Nichols, Sean M. Curtis, Joseph V. Vo, Apurba K. Bhattacharjee, Clare E. Gutteridge, Darshan S. Thota, Constance O. Asher, Gettayacamin Montip, Damaris S. Diaz
Publikováno v:
Bioorganicmedicinal chemistry letters. 16(21)
Investigation of a series of 1-phenyl-3-aryl-2-propen-1-ones resulted in the identification of nine inhibitors with submicromolar efficacy against at least one Plasmodium falciparum strain in vitro. These inhibitors were inactive when given orally in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff767b8dc2ad9ae15c9228450aeb7fe3
https://pubmed.ncbi.nlm.nih.gov/16908136
https://pubmed.ncbi.nlm.nih.gov/16908136
Publikováno v:
Combinatorial chemistryhigh throughput screening. 8(1)
The high level of attrition of drugs in clinical development has led pharmaceutical companies to increase the efficiency of their lead identification and development through techniques such as combinatorial chemistry and high-throughput (HTP) screeni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::979c5cde19033acf68bc2807b9f73bf1
https://pubmed.ncbi.nlm.nih.gov/15720200
https://pubmed.ncbi.nlm.nih.gov/15720200