Zobrazeno 1 - 10
of 258
pro vyhledávání: '"Constance L. Cepko"'
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 19, Iss , Pp 376-386 (2020)
Gene therapy with recombinant adeno-associated viral (AAV) vectors is a promising modality for the treatment of a variety of human diseases. Nonetheless, there remain significant gaps in our understanding of AAV vector biology, due in part to the lac
Externí odkaz:
https://doaj.org/article/a01a18cf1729403a9a933268be62fc27
Autor:
Sean K. Wang, Constance L. Cepko
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Microglia have been implicated in many degenerative eye disorders, including retinitis pigmentosa, age-related macular degeneration, glaucoma, diabetic retinopathy, uveitis, and retinal detachment. While the exact roles of microglia in these conditio
Externí odkaz:
https://doaj.org/article/6a1b0674c93d4d3a8e65753a4a4a65d8
Publikováno v:
JCI Insight, Vol 6, Iss 16 (2021)
Inherited retinal diseases, such as retinitis pigmentosa (RP), can be caused by thousands of different mutations, a small number of which have been successfully treated with gene replacement. However, this approach has yet to scale and may not be fea
Externí odkaz:
https://doaj.org/article/f49b573c413544e881e14dffffca9c18
Autor:
David M. Wu, Xuke Ji, Maryna V. Ivanchenko, Michelle Chung, Mary Piper, Parimal Rana, Sean K. Wang, Yunlu Xue, Emma West, Sophia R. Zhao, Hongbin Xu, Marcelo Cicconet, Wenjun Xiong, Constance L. Cepko
Publikováno v:
JCI Insight, Vol 6, Iss 2 (2021)
Nrf2, a transcription factor that regulates the response to oxidative stress, has been shown to rescue cone photoreceptors and slow vision loss in mouse models of retinal degeneration (rd). The retinal pigment epithelium (RPE) is damaged in these mod
Externí odkaz:
https://doaj.org/article/66ed3b635a034060a47e1f54e323c711
Publikováno v:
eLife, Vol 12 (2024)
Retinitis pigmentosa (RP) is an inherited retinal disease in which there is a loss of cone-mediated daylight vision. As there are >100 disease genes, our goal is to preserve cone vision in a disease gene-agnostic manner. Previously we showed that ove
Externí odkaz:
https://doaj.org/article/0a00cd426c0d4251bf3967392aecdb3f
Publikováno v:
eLife, Vol 11 (2022)
Retinitis Pigmentosa (RP) is a progressive, debilitating visual disorder caused by mutations in a diverse set of genes. In both humans with RP and mouse models of RP, rod photoreceptor dysfunction leads to loss of night vision, and is followed by sec
Externí odkaz:
https://doaj.org/article/7260d51236774fecbd6b2410649f4948
Autor:
Yunlu Xue, Sean K Wang, Parimal Rana, Emma R West, Christin M Hong, Helian Feng, David M Wu, Constance L Cepko
Publikováno v:
eLife, Vol 10 (2021)
Retinitis pigmentosa (RP) is an inherited retinal disease affecting >20 million people worldwide. Loss of daylight vision typically occurs due to the dysfunction/loss of cone photoreceptors, the cell type that initiates our color and high-acuity visi
Externí odkaz:
https://doaj.org/article/1d602be0a51c44ae81306f4e01339bb2
Autor:
Ryoji Amamoto, Mauricio D Garcia, Emma R West, Jiho Choi, Sylvain W Lapan, Elizabeth A Lane, Norbert Perrimon, Constance L Cepko
Publikováno v:
eLife, Vol 8 (2019)
Recent transcriptional profiling technologies are uncovering previously-undefined cell populations and molecular markers at an unprecedented pace. While single cell RNA (scRNA) sequencing is an attractive approach for unbiased transcriptional profili
Externí odkaz:
https://doaj.org/article/9026574e8ffd44f28611f6f67c62f112
Autor:
Jocelyn Y. Kishi, Ninning Liu, Emma R. West, Kuanwei Sheng, Jack J. Jordanides, Matthew Serrata, Constance L. Cepko, Sinem K. Saka, Peng Yin
Publikováno v:
Nature Methods. 19:1393-1402
We present Light-Seq, an approach for multiplexed spatial indexing of intact biological samples using light-directed DNA barcoding in fixed cells and tissues followed by ex situ sequencing. Light-Seq combines spatially targeted, rapid photocrosslinki
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0082889b9f25164a5d5f2af71d3ad268
https://doi.org/10.1038/s41592-022-01604-1
https://doi.org/10.1038/s41592-022-01604-1
Autor:
Constance L. Cepko, Emma R. West
Publikováno v:
Developmental Biology. 481:30-42
The bipolar interneurons of the mammalian retina have evolved as a diverse set of cells with distinct subtype characteristics, which reflect specialized contributions to visual circuitry. Fifteen subtypes of bipolar interneurons have been identified
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf803db2058bcfdca3b8fdea64cd73f4
https://doi.org/10.1016/j.ydbio.2021.09.005
https://doi.org/10.1016/j.ydbio.2021.09.005