Zobrazeno 1 - 10
of 416
pro vyhledávání: '"Constance L. Cepko"'
Autor:
Brownlee, Christen
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, 2004 Jan 01. 101(1), 14-15.
Externí odkaz:
https://www.jstor.org/stable/3148364
Publikováno v:
eLife, Vol 12 (2024)
Retinitis pigmentosa (RP) is an inherited retinal disease in which there is a loss of cone-mediated daylight vision. As there are >100 disease genes, our goal is to preserve cone vision in a disease gene-agnostic manner. Previously we showed that ove
Externí odkaz:
https://doaj.org/article/0a00cd426c0d4251bf3967392aecdb3f
Autor:
Laura Bonetta
Publikováno v:
BioTechniques, Vol 36, Iss 5, p 737 (2004)
Externí odkaz:
https://doaj.org/article/3fc9c8d4c24f42b79e9c09dd35f015cf
Publikováno v:
eLife, Vol 11 (2022)
Conventional antibodies and their derived fragments are difficult to deploy against intracellular targets in live cells, due to their bulk and structural complexity. Nanobodies provide an alternative modality, with well-documented examples of intrace
Externí odkaz:
https://doaj.org/article/1134d424fafa4bb2a792136ef86df0c4
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 19, Iss , Pp 376-386 (2020)
Gene therapy with recombinant adeno-associated viral (AAV) vectors is a promising modality for the treatment of a variety of human diseases. Nonetheless, there remain significant gaps in our understanding of AAV vector biology, due in part to the lac
Externí odkaz:
https://doaj.org/article/a01a18cf1729403a9a933268be62fc27
Publikováno v:
eLife, Vol 11 (2022)
Retinitis Pigmentosa (RP) is a progressive, debilitating visual disorder caused by mutations in a diverse set of genes. In both humans with RP and mouse models of RP, rod photoreceptor dysfunction leads to loss of night vision, and is followed by sec
Externí odkaz:
https://doaj.org/article/7260d51236774fecbd6b2410649f4948
Autor:
Sean K. Wang, Constance L. Cepko
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Microglia have been implicated in many degenerative eye disorders, including retinitis pigmentosa, age-related macular degeneration, glaucoma, diabetic retinopathy, uveitis, and retinal detachment. While the exact roles of microglia in these conditio
Externí odkaz:
https://doaj.org/article/6a1b0674c93d4d3a8e65753a4a4a65d8
Publikováno v:
JCI Insight, Vol 6, Iss 16 (2021)
Inherited retinal diseases, such as retinitis pigmentosa (RP), can be caused by thousands of different mutations, a small number of which have been successfully treated with gene replacement. However, this approach has yet to scale and may not be fea
Externí odkaz:
https://doaj.org/article/f49b573c413544e881e14dffffca9c18
Autor:
Christen Brownlee
Publikováno v:
Proceedings of the National Academy of Sciences. 101:14-15
Constance (Connie) Cepko, a developmental biologist and head of Harvard Medical School's Biological and Biomedical Sciences graduate program, has made extraordinary contributions toward understanding development of the vertebrate CNS. A Howard Hughes
Autor:
Yunlu Xue, Sean K Wang, Parimal Rana, Emma R West, Christin M Hong, Helian Feng, David M Wu, Constance L Cepko
Publikováno v:
eLife, Vol 10 (2021)
Retinitis pigmentosa (RP) is an inherited retinal disease affecting >20 million people worldwide. Loss of daylight vision typically occurs due to the dysfunction/loss of cone photoreceptors, the cell type that initiates our color and high-acuity visi
Externí odkaz:
https://doaj.org/article/1d602be0a51c44ae81306f4e01339bb2