Zobrazeno 1 - 10
of 281
pro vyhledávání: '"Constance L Cepko"'
Publikováno v:
eLife, Vol 12 (2024)
Retinitis pigmentosa (RP) is an inherited retinal disease in which there is a loss of cone-mediated daylight vision. As there are >100 disease genes, our goal is to preserve cone vision in a disease gene-agnostic manner. Previously we showed that ove
Externí odkaz:
https://doaj.org/article/0a00cd426c0d4251bf3967392aecdb3f
Publikováno v:
eLife, Vol 11 (2022)
Conventional antibodies and their derived fragments are difficult to deploy against intracellular targets in live cells, due to their bulk and structural complexity. Nanobodies provide an alternative modality, with well-documented examples of intrace
Externí odkaz:
https://doaj.org/article/1134d424fafa4bb2a792136ef86df0c4
Publikováno v:
eLife, Vol 11 (2022)
Retinitis Pigmentosa (RP) is a progressive, debilitating visual disorder caused by mutations in a diverse set of genes. In both humans with RP and mouse models of RP, rod photoreceptor dysfunction leads to loss of night vision, and is followed by sec
Externí odkaz:
https://doaj.org/article/7260d51236774fecbd6b2410649f4948
Autor:
Yunlu Xue, Sean K Wang, Parimal Rana, Emma R West, Christin M Hong, Helian Feng, David M Wu, Constance L Cepko
Publikováno v:
eLife, Vol 10 (2021)
Retinitis pigmentosa (RP) is an inherited retinal disease affecting >20 million people worldwide. Loss of daylight vision typically occurs due to the dysfunction/loss of cone photoreceptors, the cell type that initiates our color and high-acuity visi
Externí odkaz:
https://doaj.org/article/1d602be0a51c44ae81306f4e01339bb2
Autor:
Ryoji Amamoto, Mauricio D Garcia, Emma R West, Jiho Choi, Sylvain W Lapan, Elizabeth A Lane, Norbert Perrimon, Constance L Cepko
Publikováno v:
eLife, Vol 8 (2019)
Recent transcriptional profiling technologies are uncovering previously-undefined cell populations and molecular markers at an unprecedented pace. While single cell RNA (scRNA) sequencing is an attractive approach for unbiased transcriptional profili
Externí odkaz:
https://doaj.org/article/9026574e8ffd44f28611f6f67c62f112
Publikováno v:
eLife, Vol 6 (2017)
Vertebrate photoreceptors are among the most metabolically active cells, exhibiting a high rate of ATP consumption. This is coupled with a high anabolic demand, necessitated by the diurnal turnover of a specialized membrane-rich organelle, the outer
Externí odkaz:
https://doaj.org/article/d2e5cbd568674a0eb1cfc16c6b734f07
Autor:
Jonathan CY Tang, Eugene Drokhlyansky, Behzad Etemad, Stephanie Rudolph, Binggege Guo, Sui Wang, Emily G Ellis, Jonathan Z Li, Constance L Cepko
Publikováno v:
eLife, Vol 5 (2016)
The ability to detect and/or manipulate specific cell populations based upon the presence of intracellular protein epitopes would enable many types of studies and applications. Protein binders such as nanobodies (Nbs) can target untagged proteins (an
Externí odkaz:
https://doaj.org/article/e933d62fb57a4584bbb48addf8ffc84e
Publikováno v:
Frontiers in Neural Circuits, Vol 7 (2013)
Defining the connections among neurons is critical to our understanding of the structure and function of the nervous system. Recombinant viruses engineered to transmit across synapses provide a powerful approach for the dissection of neuronal circuit
Externí odkaz:
https://doaj.org/article/c02cc73cb6b44d549fed7945876d5e62
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e69314 (2013)
The mammalian inner ear subserves the special senses of hearing and balance. The auditory and vestibular sensory epithelia consist of mechanically sensitive hair cells and associated supporting cells. Hearing loss and balance dysfunction are most fre
Externí odkaz:
https://doaj.org/article/30e05e9edd9249eb834d72e479f46fb4
Publikováno v:
PLoS ONE, Vol 5, Iss 10, p e13739 (2010)
Thyroid hormone (TH) signaling components are expressed during retinal development in dynamic spatial and temporal patterns. To probe the competence of retinal cells to mount a transcriptional response to TH, reporters that included thyroid response
Externí odkaz:
https://doaj.org/article/3cb77f66468642f48e2f93a1bfdb9213