Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Constance Kohler"'
Autor:
Karen Collins, Nan Zhang, Robert Mallon, Steven C. Kim, Allan Wissner, Carolyn Discafani, Dennis Powell, Constance Kohler, Jeremy I. Levin, Donald Wojciechowicz, Diane H. Boschelli, Dan Maarten Berger, Minu Dutia, Xuemei Du, Nancy Torres, Larry Feldberg, Biqi Wu, M. Brawner Floyd
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 13:3031-3034
4-[3-Chloro-4-(1-methyl-1H-imidazol-2-ylsulfanyl)]anilino-6,7-diethoxy-3-quinolinecarbonitrile (3) was identified as a MEK1 kinase inhibitor with exceptional activity against LoVo cells. The structure-activity relationships of the C-4 aniline substit
Autor:
Robert Mallon, Donald Wojciechowicz, Larry Feldberg, Karen Collins, Constance Kohler, Irwin Hollander, Steven C. Kim, Eleanora D. Kovacs
Publikováno v:
Analytical Biochemistry. 294:48-54
The Ras-MAPK signaling cascade transmits mitogenic stimuli from growth factor receptors and activated Ras to the cell nucleus. Inappropriate Ras activation is associated with approximately 30% of all human cancers. The kinase components of the Ras-MA
Autor:
Allan Wissner, Dennis Powell, Robert Mallon, A. Yanong Wang, Larry Feldberg, Constance Kohler, Nan Zhang, Lourdes Toral-Barza, Biqi Wu, Nancy H. Eudy, Fei Ye, Eleonora D. Kovacs, Steven C. Kim
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 11:1407-1410
A series of 4-anilino-3-cyano-6,7-dialkoxyquinolines with different substituents attached to the 4-anilino group has been prepared that are potent MEK (MAP kinase kinase) inhibitors. The best activity is obtained when a phenyl or a thienyl group is a
Autor:
Allan Wissner, Zhang Nan, Biqi Wu, Frank Boschelli, Constance Kohler, Dennis Powell, Sridhar K. Rabindran
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 12:423-425
A series of 4-anilino-3-cyanobenzo[g]quinolines was prepared as potent kinase inhibitors. Compared with their bicyclic 4-anilino-3-cyanoquinoline analogues, the tricyclic 4-anilino-3-cyanobenzo[g]quinolines are less active against EGF-R kinase, equal
Publikováno v:
Inflammation. 17:245-261
Several 1-alkyl ether lipids were studied for their ability to inhibit PLA2 and antagonize PAF responses. Studies with synthetic micellar substrate (1-stearyl-2-arachidonyl phosphocholine), at concentrations ranging from 0.02 to 1000 microM, demonstr
Autor:
Michael P. Trova, Suresh S. Kerwar, Walter C. Pickett, Constance Kohler, Robert E. Schaub, Allan Wissner, Lawrence Wayne Torley, Marion L. Carroll
Publikováno v:
Journal of Medicinal Chemistry. 36:580-590
A series of platelet activating factor (PAF) antagonists containing a quaternary pyridinium ring connected through an amide, imide, or carbamate linkage to a substituted aromatic ring was prepared. Of these compounds, those containing a branched imid
Autor:
Dennis Powell, Allan Wissner, Constance Kohler, Zhang Nan, Biqi Wu, Sridhar K. Rabindran, Frank Boschelli
Publikováno v:
ChemInform. 33
A series of 4-anilino-3-cyanobenzo[g]quinolines was prepared as potent kinase inhibitors. Compared with their bicyclic 4-anilino-3-cyanoquinoline analogues, the tricyclic 4-anilino-3-cyanobenzo[g]quinolines are less active against EGF-R kinase, equal
Autor:
Robert E. Schaub, Lawrence W. Torley, Arnold L. Oronsky, M L Carroll, Allan Wissner, Susan Quinn DeJoy, Suresh S. Kerwar, Constance Kohler, Walter C. Pickett
Publikováno v:
Antimicrobial Agents and Chemotherapy. 36:1971-1977
The effect of CL 184,005, a potent and specific platelet-activating factor antagonist, has been examined in a variety of animal models relevant to gram-negative bacterial sepsis. Pretreatment of mice with CL 184,005 protected them from the lethal eff
Autor:
Suresh S. Kerwar, Lawrence Wayne Torley, Constance Kohler, Marion L. Carroll, Allan Wissner, Walter C. Pickett, S Wrenn, Robert E. Schaub, K E Green
Publikováno v:
Journal of Medicinal Chemistry. 35:1650-1662
A series of aryl phosphoglyceride (3, 19-61) and bis-aryl phosphate (67-135) antagonists of platelet activating factor (PAF) were prepared. A group of four bifunctional phosphorus reagents (5a-c and 7) were developed that allowed the preparation of t
Autor:
Eleonora D. Kovacs, Allan Wissner, Lourdes Toral-Barza, Middleton Brawner Floyd, Biqi Wu, Constance Kohler, Dennis Powell, Nan Zhang
Publikováno v:
ChemInform. 32