Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Constance Ketterer"'
Autor:
Daniel Mueller, Constance Ketterer, Diane Kraemer, Carolin Heidemann-Dinger, Lena Pilgermayer, Thomas Weber, Andreas Gericke, Frank Totzke, Michael H. Kubbutat
Publikováno v:
Cancer Research. 83:5980-5980
Cyclin dependent kinases (CDK) form a family of 20 different CDKs with an additional 6 CDK-like proteins. Members of this family have been shown to be involved in the regulation of many critical cellular processes, including the regulation of cell cy
Autor:
Daniel Müller, Frank Totzke, Thomas Weber, Andreas Gericke, Diane Krämer, Carolin Heidemann-Dinger, Constance Ketterer, Michael H. Kubbutat
Publikováno v:
Cancer Research. 82:2304-2304
The family of human Cyclin dependent kinases (CDKs) comprises 20 different CDKs that play critical roles in the regulation of cell cycle progression, gene transcription and neuronal function. Deregulation of different CDKs is frequently observed in h
Autor:
Marianne Birkle, Ralph Graeser, Sarah Umber, Christoph Schaechtele, Frank Totzke, Daniel Müller, Kurt Ballmer-Hofer, Daniel Feger, Oliver Siedentopf, Alexandra Ortiz, Holger Weber, Constance Ketterer, Michael H.G. Kubbutat, Jan E. Ehlert, Melanie Müller
Publikováno v:
Journal of biomolecular screening
Many receptor tyrosine kinases (RTKs) represent bona fide drug targets in oncology. Effective compounds are available, but treatment invariably leads to resistance, often due to RTK mutations. The discovery of second-generation inhibitors requires ce
Autor:
Diane Krämer, Carolin Heidemann-Dinger, Frank Totzke, Daniel Mueller, Thomas Weber, Marcel Pathe, Michael H.G. Kubbutat, Constance Ketterer
Publikováno v:
Cancer Research. 77:4186-4186
Protein kinases are central to cellular signal transduction and regulation of cellular processes, and are one of the most attractive target classes in modern drug discovery. Multiple kinase inhibitors have already been approved for treatment of vario
Autor:
Diane Kraemer, Carolin Heidemann-Dinger, Christian Beisenherz-Huss, Frank Totzke, Thomas Weber, Daniel Mueller, Chris Eckert, Constance Ketterer, Michael H.G. Kubbutat
Publikováno v:
Cancer Research. 76:2821-2821
Members of the family of cyclin dependent kinases (CDKs) have been recognized as pivotal regulators of cell cycle progression for more than 20 years. Concordant to their central role in the control of cell division they have been in the focus of rese
Autor:
Frank Totzke, Christian Beisenherz-Huss, Thomas Weber, Daniel Mueller, Carolin Heidemann-Dinger, Diane Krämer, Constance Ketterer, Michael H.G. Kubbutat
Publikováno v:
Cancer Research. 75:4781-4781
Gene expression is regulated by multiple mechanisms. The structure of the chromatin has been identified as one major regulator of gene expression. Histone proteins constitute the core of the nucleosomal particles, which are essential for structuring
Autor:
Diane Krämer, Daniel Mueller, Christian Beisenherz-Huss, Constance Ketterer, Michael H.G. Kubbutat, Carolin Heidemann-Dinger
Publikováno v:
Cancer Research. 74:5160-5160
The epigenetic regulation of gene expression has been of increasing interest in the last couple of years. It has been shown that methylation of DNA may pass information epigenetically even from one cellular generation to the next without changing the
Autor:
Daniel J. Müller, Thomas Weber, Christian Beisenherz-Huss, Constance Ketterer, Michael H.G. Kubbutat, Carolin Heidemann-Dinger, Frank Totzke
Publikováno v:
Cancer Research. 73:5168-5168
Protein kinases regulate a variety of biological signaling pathways affecting cell proliferation, differentiation, migration and apoptosis. In tumor cells the activity of many protein kinases are frequently found to be upregulated linking deregulatio