Zobrazeno 1 - 10
of 87
pro vyhledávání: '"Constance J. Temm"'
Autor:
Brijesh Kumar, Aditi S. Khatpe, Jiang Guanglong, Katie Batic, Poornima Bhat-Nakshatri, Maggie M. Granatir, Rebekah Joann Addison, Megan Szymanski, Lee Ann Baldridge, Constance J. Temm, George Sandusky, Sandra K. Althouse, Michele L. Cote, Kathy D. Miller, Anna Maria Storniolo, Harikrishna Nakshatri
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-22 (2023)
Abstract The biologic basis of genetic ancestry-dependent variability in disease incidence and outcome is just beginning to be explored. We recently reported enrichment of a population of ZEB1-expressing cells located adjacent to ductal epithelial ce
Externí odkaz:
https://doaj.org/article/75421f2ad75f4636aa0061e39d6146f1
Autor:
Natascia Marino, Rana German, Ram Podicheti, Pam Rockey, George E. Sandusky, Constance J. Temm, Harikrishna Nakshatri, Rebekah J. Addison, Bryce Selman, Sandra K. Althouse, Anna Maria V. Storniolo
Publikováno v:
Biomarker Research, Vol 10, Iss 1, Pp 1-14 (2022)
Abstract Background Family with sequence similarity 83 member A (FAM83A) presents oncogenic properties in several cancers including breast cancer. Recently, we reported FAM83A overexpression in normal breast tissues from women at high risk of breast
Externí odkaz:
https://doaj.org/article/b3e3501ede8049048f8b9f8fa1ffad63
Autor:
Aditi S. Khatpe, Rebecca Dirks, Poornima Bhat-Nakshatri, Henry Mang, Katie Batic, Sarah Swiezy, Jacob Olson, Xi Rao, Yue Wang, Hiromi Tanaka, Sheng Liu, Jun Wan, Duojiao Chen, Yunlong Liu, Fang Fang, Sandra Althouse, Emily Hulsey, Maggie M. Granatir, Rebekah Addison, Constance J. Temm, George Sandusky, Audrey Lee-Gosselin, Kenneth Nephew, Kathy D. Miller, Harikrishna Nakshatri
Publikováno v:
Cancer Research. 83:1345-1360
Study of genomic aberrations leading to immortalization of epithelial cells has been technically challenging due to the lack of isogenic models. To address this, we used healthy primary breast luminal epithelial cells of different genetic ancestry an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d80bdbe8f7e3fd859b87ba6cb6728f30
https://doi.org/10.1158/0008-5472.can-22-3667
https://doi.org/10.1158/0008-5472.can-22-3667
Autor:
Kayla A. Quirin, Jason J. Kwon, Arafat Alioufi, Tricia Factora, Constance J. Temm, Max Jacobsen, George E. Sandusky, Kim Shontz, Louis G. Chicoine, K. Reed Clark, Joshua T. Mendell, Murray Korc, Janaiah Kota
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 8, Iss C, Pp 8-20 (2018)
Recombinant adeno-associated virus (rAAV)-mediated gene delivery shows promise to transduce the pancreas, but safety/efficacy in a neoplastic context is not well established. To identify an ideal AAV serotype, route, and vector dose and assess safety
Externí odkaz:
https://doaj.org/article/cf264a0361034b6aa1a667a262402c19
Autor:
Harikrishna Nakshatri, Kathy D. Miller, Kenneth Nephew, Audrey Lee-Gosselin, George Sandusky, Constance J. Temm, Rebekah Addison, Maggie M. Granatir, Emily Hulsey, Sandra Althouse, Fang Fang, Yunlong Liu, Duojiao Chen, Jun Wan, Sheng Liu, Hiromi Tanaka, Yue Wang, Xi Rao, Jacob Olson, Sarah Swiezy, Katie Batic, Henry Mang, Poornima Bhat-Nakshatri, Rebecca Dirks, Aditi S. Khatpe
Table S9: Results of ATAC-seq of primary and TONSL-immortalized cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2aebc890399e5bfe96f54d95a43428de
https://doi.org/10.1158/0008-5472.22633261.v1
https://doi.org/10.1158/0008-5472.22633261.v1
Autor:
Harikrishna Nakshatri, Kathy D. Miller, Kenneth Nephew, Audrey Lee-Gosselin, George Sandusky, Constance J. Temm, Rebekah Addison, Maggie M. Granatir, Emily Hulsey, Sandra Althouse, Fang Fang, Yunlong Liu, Duojiao Chen, Jun Wan, Sheng Liu, Hiromi Tanaka, Yue Wang, Xi Rao, Jacob Olson, Sarah Swiezy, Katie Batic, Henry Mang, Poornima Bhat-Nakshatri, Rebecca Dirks, Aditi S. Khatpe
Study of genomic aberrations leading to immortalization of epithelial cells has been technically challenging due to the lack of isogenic models. To address this, we used healthy primary breast luminal epithelial cells of different genetic ancestry an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a02b10f9fff51b50bf5355116b3f214
https://doi.org/10.1158/0008-5472.c.6599674.v1
https://doi.org/10.1158/0008-5472.c.6599674.v1
Supplementary Data from TONSL Is an Immortalizing Oncogene and a Therapeutic Target in Breast Cancer
Autor:
Harikrishna Nakshatri, Kathy D. Miller, Kenneth Nephew, Audrey Lee-Gosselin, George Sandusky, Constance J. Temm, Rebekah Addison, Maggie M. Granatir, Emily Hulsey, Sandra Althouse, Fang Fang, Yunlong Liu, Duojiao Chen, Jun Wan, Sheng Liu, Hiromi Tanaka, Yue Wang, Xi Rao, Jacob Olson, Sarah Swiezy, Katie Batic, Henry Mang, Poornima Bhat-Nakshatri, Rebecca Dirks, Aditi S. Khatpe
Contains additional materials and methods and supplementary figures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f5b3f2a2a751789590276560b96ae52
https://doi.org/10.1158/0008-5472.22633315
https://doi.org/10.1158/0008-5472.22633315
Autor:
Harikrishna Nakshatri, George Sandusky, Constance J. Temm, Max Jacobsen, Calli Maguire, Poornima Bhat-Nakshatri, Brijesh Kumar
Breast cancers are classified into five intrinsic subtypes and 10 integrative clusters based on gene expression patterns and genomic aberrations, respectively. Although the cell-of-origin, adaptive plasticity, and genomic aberrations shape dynamic tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c4dcf4f3eb4f4ca52c446665baab05cf
https://doi.org/10.1158/1541-7786.c.6545304.v1
https://doi.org/10.1158/1541-7786.c.6545304.v1
Autor:
Harikrishna Nakshatri, George Sandusky, Constance J. Temm, Max Jacobsen, Calli Maguire, Poornima Bhat-Nakshatri, Brijesh Kumar
Supplementary Table S1: Summary of various isogenic immortalized, transformed, soft agar clones-derived, primary tumor-derived, and metastasis-derived cell lines. Supplementary Figure S1: Characterization of transformed breast epithelial cell lines g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53ddcb2db2583674299a64658bb676a1
https://doi.org/10.1158/1541-7786.22527045.v1
https://doi.org/10.1158/1541-7786.22527045.v1
Autor:
George E. Sandusky, Max Jacobsen, Constance J. Temm, Poornima Bhat-Nakshatri, Harikrishna Nakshatri, Calli Maguire, Brijesh Kumar
Publikováno v:
Mol Cancer Res
Breast cancers are classified into five intrinsic subtypes and 10 integrative clusters based on gene expression patterns and genomic aberrations, respectively. Although the cell-of-origin, adaptive plasticity, and genomic aberrations shape dynamic tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11c1642df8e3db253d31d58cdaa505e6
https://doi.org/10.1158/1541-7786.mcr-21-0163
https://doi.org/10.1158/1541-7786.mcr-21-0163