Concurrent infection with Mycobacterium tuberculosis confers robust protection against secondary infection in macaques.

Autor: Anthony M Cadena, Forrest F Hopkins, Pauline Maiello, Allison F Carey, Eileen A Wong, Constance J Martin, Hannah P Gideon, Robert M DiFazio, Peter Andersen, Philana Ling Lin, Sarah M Fortune, JoAnne L Flynn

Publikováno v: PLoS Pathogens, Vol 14, Iss 10, p e1007305 (2018)

For many pathogens, including most targets of effective vaccines, infection elicits an immune response that confers significant protection against reinfection. There has been significant debate as to whether natural Mycobacterium tuberculosis (Mtb) i

Externí odkaz: https://doaj.org/article/ad202065f80e48eeae2994517ddee81a

Heterogeneous GM-CSF signaling in macrophages is associated with control of Mycobacterium tuberculosis

Autor: Robert L. Modlin, Priscila Ribeiro Andrade, Constance J. Martin, Caroline Keegan, Sarah M. Fortune, Douglas S. Kwon, Christopher Y. Itoh, Fikadu G. Tafesse, Tracy R. Rosebrock, Bryan D. Bryson, Armel Nibasumba, Gregory H. Babunovic, Björn Corleis, Susan Realegeno

Publikováno v: Nature communications, vol 10, iss 1
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Bryson, Bryan D; Rosebrock, Tracy R; Tafesse, Fikadu G; Itoh, Christopher Y; Nibasumba, Armel; Babunovic, Gregory H; et al.(2019). Heterogeneous GM-CSF signaling in macrophages is associated with control of Mycobacterium tuberculosis.. Nature communications, 10(1), 2329. doi: 10.1038/s41467-019-10065-8. UCLA: Retrieved from: http://www.escholarship.org/uc/item/24r7p3fz
Nature Communications

Variability in bacterial sterilization is a key feature of Mycobacterium tuberculosis (Mtb) disease. In a population of human macrophages, there are macrophages that restrict Mtb growth and those that do not. However, the sources of heterogeneity in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a9750d4d6f0e6e25f1e992342899260
https://escholarship.org/uc/item/24r7p3fz

A bug’s life in the granuloma

Autor: Allison F. Carey, Sarah M. Fortune, Constance J. Martin

Publikováno v: Seminars in Immunopathology. 38:213-220

The granuloma is the defining feature of the host response to infection with Mycobacterium tuberculosis (Mtb). Despite knowing of its existence for centuries, much remains unclear regarding the host and bacterial factors that contribute to granuloma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5582a1fca939ee8254ec7ce242bfe76
https://doi.org/10.1007/s00281-015-0533-1

Digitally Barcoding

Autor: Constance J, Martin, Anthony M, Cadena, Vivian W, Leung, Philana Ling, Lin, Pauline, Maiello, Nathan, Hicks, Michael R, Chase, JoAnne L, Flynn, Sarah M, Fortune

Publikováno v: mBio

Infection with Mycobacterium tuberculosis causes a spectrum of outcomes; the majority of individuals contain but do not eliminate the infection, while a small subset present with primary active tuberculosis (TB) disease. This variability in infection

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::79ba91c17f8771ab7c1e19bfa742afaf
https://pubmed.ncbi.nlm.nih.gov/28487426

A functional role for antibodies in tuberculosis

Autor: Constance J. Martin, Sarah M. Fortune, Hendrik Streeck, Alison E. Mahan, Musie Ghebremichael, Tracy R. Rosebrock, Galit Alter, Elizabeth Tkachenko, Manu P. Kumar, Lenette L. Lu, Katherine J. Freedberg, Vivian Leung, Fikadu G. Tafesse, Todd J. Suscovich, Wen-Han Yu, Patricia S. Grace, Hannah Robinson, Matthew K. Schoen, Jacquelynne Tedesco, Monia Draghi, Cheryl L. Day, Magdalena Sips, Douglas A. Lauffenburger, Blanca I. Restrepo, Amy W. Chung

Publikováno v: PMC

While a third of the world carries the burden of tuberculosis, disease control has been hindered by a lack of tools, including a rapid, point-of-care diagnostic and a protective vaccine. In many infectious diseases, antibodies (Abs) are powerful biom

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47401246b9123a3a2c1569787a483fff
https://europepmc.org/articles/PMC5526202/