Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Constance H Li"'
Autor:
Nicholas Ching Wei Ho, Josephine Yu Yan Yap, Zixuan Zhao, Yunyun Wang, Kanishka Fernando, Constance H Li, Xue Lin Kwang, Hong Sheng Quah, Camille Arcinas, N. Gopalakrishna Iyer, Eliza Li Shan Fong
Publikováno v:
Advanced Science, Vol 11, Iss 20, Pp n/a-n/a (2024)
Abstract Recently mapped transcriptomic landscapes reveal the extent of heterogeneity in cancer‐associated fibroblasts (CAFs) beyond previously established single‐gene markers. Functional analyses of individual CAF subsets within the tumor microe
Externí odkaz:
https://doaj.org/article/29d702fb4fab4690857b4ee587c042cf
Autor:
Darren Wan-Teck Lim, Hsiang-Fong Kao, Lisda Suteja, Constance H. Li, Hong Sheng Quah, Daniel Shao-Weng Tan, Sze-Huey Tan, Eng-Huat Tan, Wan-Ling Tan, Justina Nadia Lee, Felicia Yu-Ting Wee, Amit Jain, Boon-Cher Goh, Melvin L. K. Chua, Bin-Chi Liao, Quan Sing Ng, Ruey-Long Hong, Mei-Kim Ang, Joe Poh-Sheng Yeong, N. Gopalakrishna Iyer
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract Single-agent checkpoint inhibitor (CPI) activity in Epstein-Barr Virus (EBV) related nasopharyngeal carcinoma (NPC) is limited. Dual CPI shows increased activity in solid cancers. In this single-arm phase II trial (NCT03097939), 40 patients
Externí odkaz:
https://doaj.org/article/9dac3f0d6a524296a18f65ed171dcbf2
Autor:
Hong Sheng Quah, Elaine Yiqun Cao, Lisda Suteja, Constance H. Li, Hui Sun Leong, Fui Teen Chong, Shilpi Gupta, Camille Arcinas, John F. Ouyang, Vivian Ang, Teja Celhar, Yunqian Zhao, Hui Chen Tay, Jerry Chan, Takeshi Takahashi, Daniel S. W. Tan, Subhra K. Biswas, Owen J. L. Rackham, N. Gopalakrishna Iyer
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
The molecular mechanisms underlying lymph-node metastasis in head and neck squamous-cell carcinoma remain to be investigated. Here, the authors perform single-cell RNA sequencing of cancer cells and CD8 + T cells and suggest potential mechanisms of i
Externí odkaz:
https://doaj.org/article/38255f69fa6848db9cd30e34bbfaa608
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Ageing is a known risk factor in the development of cancers, but its association with molecular alterations is not fully explored. Here, the authors analyse pan-cancer age-associated molecular alterations in datasets from the TCGA, PCAWG and AACR-GEN
Externí odkaz:
https://doaj.org/article/21fa42203ca142a696357f40e32b644c
Autor:
Constance H. Li, Stephenie D. Prokopec, Ren X. Sun, Fouad Yousif, Nathaniel Schmitz, PCAWG Tumour Subtypes and Clinical Translation, Paul C. Boutros, PCAWG Consortium
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-24 (2020)
There’s an emerging body of evidence to show how biological sex impacts cancer incidence, treatment and underlying biology. Here, using a large pan-cancer dataset, the authors further highlight how sex differences shape the cancer genome.
Externí odkaz:
https://doaj.org/article/eb0e62b5b1ad4e72be0a993246cb8d67
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
Many tumours exhibit hypoxia (low oxygen) and hypoxic tumours often respond poorly to therapy. Here, the authors quantify hypoxia in 1188 tumours from 27 cancer types, showing elevated hypoxia links to increased mutational load, directing evolutionar
Externí odkaz:
https://doaj.org/article/4c1bcf031d81481c82255bf73212374c
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-1 (2022)
Externí odkaz:
https://doaj.org/article/a7c6c3c5689843d7b356b28fd1218816
All supporting supplementary figures S1-S23
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65b48a153fb3b574286615a86dfff6ea
https://doi.org/10.1158/0008-5472.22420043
https://doi.org/10.1158/0008-5472.22420043
Description of CNA and SNV data, pancancer and tumour type-specific model variables, and summary of variables for each tumour type
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b96d03e0992e701200bce9644a4c852
https://doi.org/10.1158/0008-5472.22420040.v1
https://doi.org/10.1158/0008-5472.22420040.v1
Cancer differs significantly between men and women; even after adjusting for known epidemiologic risk factors, the sexes differ in incidence, outcome, and response to therapy. These differences occur in many but not all tumor types, and their origins
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::144401113669f94fbad099860f272d0b
https://doi.org/10.1158/0008-5472.c.6510539.v1
https://doi.org/10.1158/0008-5472.c.6510539.v1