Zobrazeno 1 - 10
of 119
pro vyhledávání: '"Constance E. Runyan"'
Autor:
Laura A. Dada, Lynn C. Welch, Natalia D. Magnani, Ziyou Ren, Hyebin Han, Patricia L. Brazee, Diego Celli, Annette S. Flozak, Anthea Weng, Mariana Maciel Herrerias, Vitalii Kryvenko, István Vadász, Constance E. Runyan, Hiam Abdala-Valencia, Masahiko Shigemura, S. Marina Casalino-Matsuda, Alexander V. Misharin, G.R. Scott Budinger, Cara J. Gottardi, Jacob I. Sznajder
Publikováno v:
JCI Insight, Vol 8, Iss 4 (2023)
Persistent symptoms and radiographic abnormalities suggestive of failed lung repair are among the most common symptoms in patients with COVID-19 after hospital discharge. In mechanically ventilated patients with acute respiratory distress syndrome (A
Externí odkaz:
https://doaj.org/article/27f8a7d5d6534376bca1fe588efdba2a
Autor:
Laura A. Dada, Lynn C. Welch, Natalia D. Magnani, Ziyou Ren, Patricia L. Brazee, Diego Celli, Annette S. Flozak, Anthea Weng, Mariana Maciel-Herrerias, Vitalii Kryvenko, István Vadász, Constance E Runyan, Hiam Abdala-Valencia, Masahiko Shigemura, S. Marina Casalino-Matsuda, Alexander V. Misharin, G.R. Scott Budinger, Cara J. Gottardi, Jacob I. Sznajder
Persistent symptoms and radiographic abnormalities suggestive of failed lung repair are among the most common symptoms in patients with COVID-19 after hospital discharge. In mechanically ventilated patients with ARDS secondary to SARS-CoV-2 pneumonia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cd9f94ba5428f83a06139ea42bb83303
https://doi.org/10.1101/2022.01.12.475264
https://doi.org/10.1101/2022.01.12.475264
Autor:
Masahiko Shigemura, Emilia Lecuona, Monica Chi, G. R. Scott Budinger, Constance E. Runyan, Luisa Morales-Nebreda, Laura A. Dada, Atsuko Shigemura, Gökhan M. Mutlu, Kathryn A. Radigan, Harris Perlman, Martín Angulo, Alexander V. Misharin, Lynn C. Welch, Ermelinda Ceco, Trevor T. Nicholson, Luciano Amarelle, Jacob I. Sznajder
Publikováno v:
The Journal of Immunology. 202:484-493
Muscle dysfunction is common in patients with adult respiratory distress syndrome and is associated with morbidity that can persist for years after discharge. In a mouse model of severe influenza A pneumonia, we found the proinflammatory cytokine IL-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5988730bcf0735058342e5cde7b0e9de
https://doi.org/10.4049/jimmunol.1701433
https://doi.org/10.4049/jimmunol.1701433
Autor:
G. R. Scott Budinger, Rogan A. Grant, Cara J. Gottardi, Hermon Kihshen, Mariana Maciel, Hiam Abdala-Valencia, Saul Soberanes, Nikolay S. Markov, Kiwon Nam, Katherine Gruner, Jacob I. Sznajder, Alexandra C. McQuattie-Pimentel, Paul A. Reyfman, Lango Sichizya, Raul Piseaux Aillon, Ziyou Ren, Alexander V. Misharin, Richard I. Morimoto, Ziyan Lu, Constance E. Runyan, Yuliya Politanska, Manu Jain, Satoshi Watanabe, Nikita Joshi
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Disordered epithelial proteostasis is strongly implicated in the pathobiology of pulmonary fibrosis. We found that a small molecule that specifically restores protein translation by EIF2B during activation of the integrated stress respon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14d154da866a662067f77a54c714cee8
https://pubmed.ncbi.nlm.nih.gov/33972447
https://pubmed.ncbi.nlm.nih.gov/33972447
Autor:
Alexander V. Misharin, Gökhan M. Mutlu, Ziyou Ren, James M. Walter, Nikita Joshi, Benjamin D. Singer, Satoshi Watanabe, Zhangying Chen, Ching I. Chen, Jennifer M. Davis, Thomas Stoeger, Jacob I. Sznajder, Kiwon Nam, Monica Chi, Constance E. Runyan, Ankit Bharat, G. R. Scott Budinger, Saul Soberanes, Harris Perlman, Kathryn A. Helmin, Navdeep S. Chandel, Angelo Y. Meliton, Kishore R. Anekalla, Karen M. Ridge, Paul A. Reyfman, Raul Piseaux Aillon, William E. Balch, Cara J. Gottardi, Lango Sichizya, Hiam Abdala-Valencia, Deborah R. Winter, Alexandra C. McQuattie-Pimentel, Richard I. Morimoto, Ziyan Lu
Publikováno v:
J Clin Invest
Alveolar macrophages orchestrate the response to viral infections. Age-related changes in these cells may underlie the differential severity of pneumonia in older patients. We performed an integrated analysis of single-cell RNA-Seq data that revealed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1aae453d0fc5ceac6513a64c6915ede9
https://doi.org/10.1172/jci140299
https://doi.org/10.1172/jci140299
Autor:
Nikita Joshi, Satoshi Watanabe, Emilia Lecuona, Kiwon Nam, Raul Piseaux-Aillon, G. R. Scott Budinger, Masahiko Shigemura, Kinola J.N. Williams, Nikolay S. Markov, Constance E. Runyan, Yuliya Politanska, Alexander V. Misharin, Luciano Amarelle, Jacob I. Sznajder, Hiam Abdala-Valencia, Alexandra C. McQuattie-Pimentel, Lango Sichizya, Ziyan Lu, Lynn C. Welch
Publikováno v:
Aging Cell. 19
Skeletal muscle dysfunction in survivors of pneumonia disproportionately affects older individuals in whom it causes substantial morbidity. We found that skeletal muscle recovery was impaired in old compared with young mice after influenza A virus-in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b5fb89cd32dc80ad887b480a5a3d9934
https://doi.org/10.1111/acel.13180
https://doi.org/10.1111/acel.13180
Autor:
Hiam Abdala-Valencia, Lango Sichizya, Nikita Joshi, Raul Piseaux Aillon, Lynn C. Welch, Satoshi Watanabe, Alexander V. Misharin, G.S. Budinger, Ziyan Lu, Alexandra C. McQuattie-Pimentel, Nikolay S. Markov, Jacob I. Sznajder, Emilia Lecuona, Constance E. Runyan, Masahiko Shigemura, Kinola J.N. Williams
Publikováno v:
B29. INFECTION AND IMMUNE INTERPLAY IN LUNG INJURY.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f509a0ef6c0ea48cffd1171109623203
https://doi.org/10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a2970
https://doi.org/10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a2970
Autor:
G. R. Scott Budinger, Yuliya Politanska, Mariana Maciel, Raul Piseaux Aillon, Nikolay S. Markov, Satoshi Watanabe, Hermon Kihshen, Rogan A. Grant, Saul Soberanes, Nikita Joshi, Constance E. Runyan, Hiam Abdala-Valencia, Alexandra C. McQuattie-Pimentel, Kiwon Nam, Paul A. Reyfman, Ziyou Ren, Lango Sichizya, Alexander V. Misharin, Richard I. Morimoto, Ziyan Lu
Aging is among the most important risk factors for the development of pulmonary fibrosis. We found that a small molecule that specifically inhibits translational inhibition induced by activation of the integrated stress response (ISRIB) attenuated th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f90cbc427693838be5b3045e46f3701
Autor:
Constance E, Runyan, Lynn C, Welch, Emilia, Lecuona, Masahiko, Shigemura, Luciano, Amarelle, Hiam, Abdala-Valencia, Nikita, Joshi, Ziyan, Lu, Kiwon, Nam, Nikolay S, Markov, Alexandra C, McQuattie-Pimentel, Raul, Piseaux-Aillon, Yuliya, Politanska, Lango, Sichizya, Satoshi, Watanabe, Kinola J N, Williams, G R Scott, Budinger, Jacob I, Sznajder, Alexander V, Misharin
Publikováno v:
Aging Cell
Skeletal muscle dysfunction in survivors of pneumonia disproportionately affects older individuals in whom it causes substantial morbidity. We found that skeletal muscle recovery was impaired in old compared with young mice after influenza A virus‐
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e9e896049429d3bbe71ef3debb0557d6
https://pubmed.ncbi.nlm.nih.gov/32720752
https://pubmed.ncbi.nlm.nih.gov/32720752
Autor:
Jacob I. Sznajder, Hiam Abdala-Valencia, Emilia Lecuona, Lango Sichizya, Ziyan Lu, Satoshi Watanabe, Nikolay S. Markov, Nikita Joshi, Alexandra C. McQuattie-Pimentel, Raul Piseaux-Aillon, Lynn C. Welch, Luciano Amarelle, Kiwon Nam, Alexander V. Misharin, Yuliya Politanska, Constance E. Runyan, G. R. Scott Budinger, Masahiko Shigemura, Kinola J.N. Williams
Skeletal muscle dysfunction in survivors of pneumonia is a major cause of lasting morbidity that disproportionately affects older individuals. We found that skeletal muscle recovery was impaired in aged compared with young mice after influenza A viru
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f2961628056e531f1149f584ce42113