v-src-Induced Cell Shape Changes in Rat Fibroblasts Require New Gene Transcription and Precede Loss of Focal Adhesions

Autor: Ed Roos, James B. McCarthy, Constance A. Feltkamp, Lisette Ruuls-Van Stalle, Alexandra M.L. Meijne

Publikováno v: Experimental Cell Research. 234:477-485

The mechanism of v-src-induced morphological transformation is still obscure. We compared LA29 rat fibroblasts, which express a temperature-sensitive (ts) v-src mutant, with D1025 rat fibroblasts, transfected with a ts mutant of v-fps. Upon transform

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39c698c61aa9009c4808de6a1abeb95c
https://doi.org/10.1006/excr.1997.3637

Organization of talin and vinculin in adhesion plaques of wet-cleaved chicken embryo fibroblasts

Autor: Constance A. Feltkamp, Ed Roos, M. A. P. Pijnenburg

Publikováno v: Journal of Cell Science. 100:579-587

We have studied the fine structure of adhesion plaques in chicken embryo fibroblasts (CEF) and visualized the localization of vinculin and talin using immunoelectron microscopy on CEF opened by ‘wet-cleaving’. This procedure, performed with nitro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04b21afe942d590f0020f744681ddb3e
https://doi.org/10.1242/jcs.100.3.579

Regulated membrane localization of Tiam1, mediated by the NH2-terminal pleckstrin homology domain, is required for Rac-dependent membrane ruffling and c-Jun NH2-terminal kinase activation

Autor: John G. Collard, L Ruuls-Van Stalle, R.A. van der Kammen, Peter L. Hordijk, Jord C. Stam, Constance A. Feltkamp, Frits Michiels

Publikováno v: Michiels, F, Stam, J C, Hordijk, P L, Van Der Kammen, R A, Stalle, L R V, Feltkamp, C A & Collard, J G 1997, ' Regulated membrane localization of Tiam1, mediated by the NH 2-terminal pleckstrin homology domain, is required for Rac-dependent membrane ruffling and c-Jun NH 2-terminal kinase activation ', Journal of Cell Biology, vol. 137, no. 2, pp. 387-398 . https://doi.org/10.1083/jcb.137.2.387
Journal of cell biology, 137(2), 387-398. Rockefeller University Press
The Journal of Cell Biology
Journal of Cell Biology, 137(2), 387-398. Rockefeller University Press

Rho-like GTPases, including Cdc42, Rac, and Rho, regulate signaling pathways that control actin cytoskeletal structures and transcriptional activation. The Tiam1 gene encodes an activator of Rac1, and similarly to constitutively activated (V12)Rac1,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39459ebd2dc538450acfd416cf2f7676
https://research.vumc.nl/en/publications/7603b652-28d4-4970-9307-fddf621f4516

Lymphoid proliferations in the orbit: malignant or benign?

Autor: Leo Koornneef, Constance A. Feltkamp, H. J. F. Peeters, J. P. A. Gillissen, Thea M. Vroom, R van der Gaag, P van Heerde, J H Pegels, G. M. Bleeker, T. E. W. Feltkamp

Publikováno v: British Journal of Ophthalmology. 68:892-900

Clinical, pathological, and immunological analysis of 20 patients with ocular adnexal lymphoid disease has demonstrated several parameters which are useful for distinguishing malignant from benign lesions. Patients in the fourth or fifth decade of li

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ad28a1377a84b9267dd749bb2d6d869
https://doi.org/10.1136/bjo.68.12.892

Localization of cell surface glycoproteins in membrane domains associated with the underlying filament network

Autor: Ed Roos, H Spiele, Constance A. Feltkamp, D.A.M. Mesland, F A Wiegant, H Huisman, J Traas

Publikováno v: The Journal of Cell Biology

To visualize the localization of cell surface constituents in relation to the plasma membrane-associated filament network, we developed a method based on a combination of immunogold labeling and dry-cleaving. For labeling we used trinitrophenyl-deriv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::376aaa4ff20eb733c55eb3bf90493529
http://europepmc.org/articles/PMC2113983