Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Constance, Cullen"'
Autor:
Dan Bloomfield, Naab M. Al‐Saady, Debra Freedholm, Sara Coulter, Norman E. Lepor, Xiaohui Wang, Nancy Widener, Mark Lovern, Constance Cullen, Byungdoo Alexander Yi, Emilie Simard
Publikováno v:
Journal of Thrombosis and Haemostasis. 20:307-315
Background Factor XI (FXI) inhibition offers the promise of hemostasis-sparing anticoagulation for the prevention and treatment of thromboembolic events. Abelacimab (MAA868) is a novel fully human monoclonal antibody that targets the catalytic domain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec2022a6f5c2560d66f2ddc2a3e2cc7c
https://doi.org/10.1111/jth.15577
https://doi.org/10.1111/jth.15577
Autor:
Laurence Fayadat-Dilman, Christine Andrews, Gulesi Ayanoglu, Liming Liu, Robert A. Kastelein, Aarron T. Willingham, Sabine Le Saux, Svetlana Sadekova, Dan Malashock, Hans van Eenennaam, Sophie Li, Ying Yu, Soonmo Peter Kang, Beth Hutchins, Andrea van Elsas, John Dulos, Rene De Waal Malefyt, Julie Lee, Frederique M. Poulet, Gregory J. Carven, Constance Cullen, Gary C. Starling, Mark Hsieh, Danuta J. Herzyk, Michel Streuli, Mark A. McCoy, George Soder
Publikováno v:
Molecular Cancer Therapeutics. 19:1298-1307
The programmed cell death 1 (PD-1) pathway represents a major immune checkpoint, which may be engaged by cells in the tumor microenvironment to overcome active T-cell immune surveillance. Pembrolizumab (Keytruda®, MK-3475) is a potent and highly sel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::44ee4cad68943c640dee7d7ddd1ef5be
https://doi.org/10.1158/1535-7163.mct-19-0774
https://doi.org/10.1158/1535-7163.mct-19-0774
Autor:
Beth, Hutchins, Gary C, Starling, Mark A, McCoy, Danuta, Herzyk, Frederique M, Poulet, John, Dulos, Liming, Liu, Soonmo Peter, Kang, Laurence, Fayadat-Dilman, Mark, Hsieh, Christine L, Andrews, Gulesi, Ayanoglu, Constance, Cullen, Rene de Waal, Malefyt, Robert A, Kastelein, Sabine Le, Saux, Julie, Lee, Sophie, Li, Dan, Malashock, Svetlana, Sadekova, George, Soder, Hans, van Eenennaam, Aarron, Willingham, Ying, Yu, Michel, Streuli, Gregory J, Carven, Andrea, van Elsas
Publikováno v:
Molecular cancer therapeutics. 19(6)
The programmed cell death 1 (PD-1) pathway represents a major immune checkpoint, which may be engaged by cells in the tumor microenvironment to overcome active T-cell immune surveillance. Pembrolizumab (Keytruda®, MK-3475) is a potent and highly sel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::10d0b6eca5fefc531e03f4842302e6d9
https://pubmed.ncbi.nlm.nih.gov/32229606
https://pubmed.ncbi.nlm.nih.gov/32229606
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 123:128-131
Yeast cells, in particular Pichia pastoris, are the host cell of choice for manufacturing several protein therapeutic agents in the biopharmaceutical industry. Host cell DNA is an impurity of such manufacturing process and the residual DNA after the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d74f9ed65331be024409f18580cf7432
https://doi.org/10.1016/j.jpba.2016.01.050
https://doi.org/10.1016/j.jpba.2016.01.050
Autor:
Xiao-Yan Cai, Constance Cullen
Publikováno v:
Immunogenicity Assay Development, Validation and Implementation. :6-17
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::133964c364630f4b90fdeb81d2762b99
https://doi.org/10.4155/ebo.13.380
https://doi.org/10.4155/ebo.13.380
Autor:
Michael A. O’Donnell, Marshall Gonzales, Narendra S Kishnani, George Sode, Colin P.N. Dinney, Maria Caceres, Nancy Ainslie, Alice Abraham, Guangcheng Zhang, Michael Kincaid, H. Barton Grossman, Ashish M. Kamat, William F. Benedict, Matthew F. Wszolek, Mark B. Fisher, David L. Cutler, Neema Navai, Sophia Young, Beth Hutchins, Daniel C. Maneval, Constance Cullen
Publikováno v:
Journal of Urology. 190:850-856
Purpose: A phase I trial of intravesical recombinant adenovirus mediated interferon-α2b gene therapy (rAd-IFNα) formulated with the excipient SCH Syn3 was conducted in patients with nonmuscle invasive bladder cancer who had disease recurrence after
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::50a3c24a2f0ba547cc32be538766771a
https://doi.org/10.1016/j.juro.2013.03.030
https://doi.org/10.1016/j.juro.2013.03.030
Publikováno v:
Bioanalysis. 3:535-540
With the imminent expiry of patents on a number of biological products on the market, the development of biosimilars (or ‘follow-on biologics’) creates an increasing opportunity in the biotechnology industry. Although general guidelines on the qu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::065c8c61e91b89f77af77bd8adc05fe7
https://doi.org/10.4155/bio.11.24
https://doi.org/10.4155/bio.11.24
Autor:
Daniel C. Maneval, Christopher M. Bral, Zoe Chen, Kimberley A. Treinen, Irwin Y. Rosenblum, Mark E. Cartwright, Robert W. Veneziale, Joseph C. Arezzo, Dinesh P. Sinha, Xiao Yan Cai, Barbara Faha, Joyce Nelson, Robert J. Munger, Robert W. Watkins, Constance Cullen, Narendra S. Kishnani
Publikováno v:
Cutaneous and Ocular Toxicology. 26:83-105
Monkey studies were conducted for the preclinical safety assessment of SCH 412499, an adenovirus encoding p21, administered by subconjunctival injection prior to trabeculectomy for postoperative maintenance of the surgical opening. Biodistribution of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70eb2c7ff7aba0ce68b1be35413bfde9
https://doi.org/10.1080/15569520701212167
https://doi.org/10.1080/15569520701212167
Publikováno v:
Analytical Biochemistry. 327:165-175
A method to assess the kinetic interactions of a humanized anti-human interleukin-5 (IL-5) monoclonal antibody (SCH 55700) with native human IL-5 using surface plasmon resonance (SPR) has been developed and validated. Since there are no clearly defin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0880e0d9a2c5b6fa1334d4967af1bc38
https://doi.org/10.1016/j.ab.2004.01.006
https://doi.org/10.1016/j.ab.2004.01.006
Autor:
Linda J. Obenauer-Kutner, Meredith Neumann, Sheila Jacobs, Constance Cullen, Leslie W Abad, Lori M Tobias
Publikováno v:
Analytical Biochemistry. 310:107-113
A biosensor-based assay, using a surface plasmon resonance detection system, was developed to detect and isotype anti-adenoviral antibodies in patients dosed with an adenoviral-based gene therapy vector. In the assay, whole, intact virus was immobili
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b845984c94dbd8408fc0e513976b2378
https://doi.org/10.1016/s0003-2697(02)00314-7
https://doi.org/10.1016/s0003-2697(02)00314-7