Immunometabolic interference between cancer and COVID-19.

Autor: Consonni FM; Department of Pharmaceutical Sciences, University of Piemonte Orientale 'A. Avogadro', Novara, Italy.; IRCCS Humanitas Clinical and Research Centre, Rozzano, Milan, Italy., Durante B; IRCCS Humanitas Clinical and Research Centre, Rozzano, Milan, Italy., Manfredi M; Department of Translational Medicine, University of Piemonte Orientale, Novara, Italy.; Center for Translational Research on Autoimmune and Allergic Diseases, University of Piemonte Orientale, Novara, Italy., Bleve A; IRCCS Humanitas Clinical and Research Centre, Rozzano, Milan, Italy., Pandolfo C; Department of Pharmaceutical Sciences, University of Piemonte Orientale 'A. Avogadro', Novara, Italy., Garlatti V; Department of Pharmaceutical Sciences, University of Piemonte Orientale 'A. Avogadro', Novara, Italy.; IRCCS Humanitas Clinical and Research Centre, Rozzano, Milan, Italy., Vanella VV; Department of Translational Medicine, University of Piemonte Orientale, Novara, Italy.; Center for Translational Research on Autoimmune and Allergic Diseases, University of Piemonte Orientale, Novara, Italy., Marengo E; Center for Translational Research on Autoimmune and Allergic Diseases, University of Piemonte Orientale, Novara, Italy.; Department of Sciences and Technological Innovation, University of Piemonte Orientale, Alessandria, Italy., Barberis E; Department of Translational Medicine, University of Piemonte Orientale, Novara, Italy.; Center for Translational Research on Autoimmune and Allergic Diseases, University of Piemonte Orientale, Novara, Italy., Bottazzi B; IRCCS Humanitas Clinical and Research Centre, Rozzano, Milan, Italy., Bombace S; Department of Cardiovascular Medicine, Humanitas Clinical and Research Center, Rozzano, Milan, Italy.; Department of Biomedical Sciences, Humanitas University, Pieve Emanuele-Milan, Italy., My I; IRCCS Humanitas Clinical and Research Centre, Rozzano, Milan, Italy.; Department of Biomedical Sciences, Humanitas University, Pieve Emanuele-Milan, Italy., Condorelli G; IRCCS Humanitas Clinical and Research Centre, Rozzano, Milan, Italy.; Department of Cardiovascular Medicine, Humanitas Clinical and Research Center, Rozzano, Milan, Italy.; Department of Biomedical Sciences, Humanitas University, Pieve Emanuele-Milan, Italy., Torri V; Istituto di Ricerche Farmacologiche Mario Negri-IRCCS, Milan, Italy., Sica A; Department of Pharmaceutical Sciences, University of Piemonte Orientale 'A. Avogadro', Novara, Italy.; IRCCS Humanitas Clinical and Research Centre, Rozzano, Milan, Italy.

Publikováno v: Frontiers in immunology [Front Immunol] 2023 Mar 29; Vol. 14, pp. 1168455. Date of Electronic Publication: 2023 Mar 29 (Print Publication: 2023).

Heme catabolism by tumor-associated macrophages controls metastasis formation.

Autor: Consonni FM; Humanitas Clinical and Research Center, IRCCS, Rozzano, Milan, Italy.; Department of Pharmaceutical Sciences, University of Piemonte Orientale 'A. Avogadro', Novara, Italy., Bleve A; Department of Pharmaceutical Sciences, University of Piemonte Orientale 'A. Avogadro', Novara, Italy., Totaro MG; Humanitas Clinical and Research Center, IRCCS, Rozzano, Milan, Italy., Storto M; Humanitas Clinical and Research Center, IRCCS, Rozzano, Milan, Italy., Kunderfranco P; Humanitas Clinical and Research Center, IRCCS, Rozzano, Milan, Italy., Termanini A; Humanitas Clinical and Research Center, IRCCS, Rozzano, Milan, Italy., Pasqualini F; Humanitas Clinical and Research Center, IRCCS, Rozzano, Milan, Italy., Alì C; Department of Pharmaceutical Sciences, University of Piemonte Orientale 'A. Avogadro', Novara, Italy., Pandolfo C; Department of Pharmaceutical Sciences, University of Piemonte Orientale 'A. Avogadro', Novara, Italy., Sgambelluri F; Department of Research, Human Tumors Immunobiology Unit, Fondazione IRCCS Istituto Nazionale Dei Tumori, Milan, Italy., Grazia G; Department of Research, Human Tumors Immunobiology Unit, Fondazione IRCCS Istituto Nazionale Dei Tumori, Milan, Italy., Santinami M; Department of Surgery, Melanoma and Sarcoma Unit, Fondazione IRCCS Istituto Nazionale Dei Tumori, Milan, Italy., Maurichi A; Department of Surgery, Melanoma and Sarcoma Unit, Fondazione IRCCS Istituto Nazionale Dei Tumori, Milan, Italy., Milione M; First Division of Pathology, Department of Pathology and Laboratory Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy., Erreni M; Humanitas Clinical and Research Center, IRCCS, Rozzano, Milan, Italy., Doni A; Humanitas Clinical and Research Center, IRCCS, Rozzano, Milan, Italy., Fabbri M; European Commission, Joint Research Centre (JRC), Ispra, Italy., Gribaldo L; European Commission, Joint Research Centre (JRC), Ispra, Italy., Rulli E; Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy., Soares MP; Instituto Gulbenkian de Ciência, Oeiras, Portugal., Torri V; Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy., Mortarini R; Department of Research, Human Tumors Immunobiology Unit, Fondazione IRCCS Istituto Nazionale Dei Tumori, Milan, Italy., Anichini A; Department of Research, Human Tumors Immunobiology Unit, Fondazione IRCCS Istituto Nazionale Dei Tumori, Milan, Italy., Sica A; Humanitas Clinical and Research Center, IRCCS, Rozzano, Milan, Italy. antonio.sica@uniupo.it.; Department of Pharmaceutical Sciences, University of Piemonte Orientale 'A. Avogadro', Novara, Italy. antonio.sica@uniupo.it.

Publikováno v: Nature immunology [Nat Immunol] 2021 May; Vol. 22 (5), pp. 595-606. Date of Electronic Publication: 2021 Apr 26.

Tumor-Derived Prostaglandin E2 Promotes p50 NF-κB-Dependent Differentiation of Monocytic MDSCs.

Autor: Porta C; Department of Pharmaceutical Sciences, Università del Piemonte Orientale 'Amedeo Avogadro', Novara, Italy.; Center for Translational Research on Autoimmune & Allergic Diseases (CAAD) Cso Trieste 15/A, Novara, Italy., Consonni FM; Humanitas Clinical and Research Center - IRCCS, Rozzano, Milan, Italy., Morlacchi S; Humanitas Clinical and Research Center - IRCCS, Rozzano, Milan, Italy., Sangaletti S; Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy., Bleve A; Department of Pharmaceutical Sciences, Università del Piemonte Orientale 'Amedeo Avogadro', Novara, Italy., Totaro MG; Humanitas Clinical and Research Center - IRCCS, Rozzano, Milan, Italy., Larghi P; Humanitas Clinical and Research Center - IRCCS, Rozzano, Milan, Italy., Rimoldi M; Humanitas Clinical and Research Center - IRCCS, Rozzano, Milan, Italy., Tripodo C; Human Pathology Section, Department of Health Sciences, University of Palermo, Palermo, Italy., Strauss L; Department of Pharmaceutical Sciences, Università del Piemonte Orientale 'Amedeo Avogadro', Novara, Italy., Banfi S; Humanitas Clinical and Research Center - IRCCS, Rozzano, Milan, Italy., Storto M; Humanitas Clinical and Research Center - IRCCS, Rozzano, Milan, Italy., Pressiani T; Humanitas Clinical and Research Center - IRCCS, Rozzano, Milan, Italy., Rimassa L; Humanitas Clinical and Research Center - IRCCS, Rozzano, Milan, Italy., Tartari S; Humanitas Clinical and Research Center - IRCCS, Rozzano, Milan, Italy., Ippolito A; Department of Pharmaceutical Sciences, Università del Piemonte Orientale 'Amedeo Avogadro', Novara, Italy., Doni A; Humanitas Clinical and Research Center - IRCCS, Rozzano, Milan, Italy., Soldà G; Humanitas Clinical and Research Center - IRCCS, Rozzano, Milan, Italy.; Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy., Duga S; Humanitas Clinical and Research Center - IRCCS, Rozzano, Milan, Italy.; Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy., Piccolo V; Humanitas Clinical and Research Center - IRCCS, Rozzano, Milan, Italy., Ostuni R; San Raffaele Telethon Institute for Gene Therapy (SR-TIGET), IRCCS San Raffaele Scientific Institute, Milan, Italy.; Vita-Salute San Raffaele University, Milan, Italy., Natoli G; Humanitas Clinical and Research Center - IRCCS, Rozzano, Milan, Italy.; Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy., Bronte V; Department of Medicine, Verona University Hospital, Verona, Italy., Balzac F; Department of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center, University of Torino, Torino, Italy., Turco E; Department of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center, University of Torino, Torino, Italy., Hirsch E; Department of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center, University of Torino, Torino, Italy., Colombo MP; Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy., Sica A; Department of Pharmaceutical Sciences, Università del Piemonte Orientale 'Amedeo Avogadro', Novara, Italy. antonio.sica@uniupo.it.; Humanitas Clinical and Research Center - IRCCS, Rozzano, Milan, Italy.

Publikováno v: Cancer research [Cancer Res] 2020 Jul 01; Vol. 80 (13), pp. 2874-2888. Date of Electronic Publication: 2020 Apr 07.

Melanoma-specific bcl-2 promotes a protumoral M2-like phenotype by tumor-associated macrophages.

Autor: Di Martile M; Preclinical Models and New Therapeutic Agents Unit, IRCCS Regina Elena National Cancer Institute, Rome, Italy., Farini V; Preclinical Models and New Therapeutic Agents Unit, IRCCS Regina Elena National Cancer Institute, Rome, Italy., Consonni FM; Molecular Immunology Lab, Humanitas Clinical and Research Center, Milan, Italy., Trisciuoglio D; Preclinical Models and New Therapeutic Agents Unit, IRCCS Regina Elena National Cancer Institute, Rome, Italy.; Institute of Molecular Biology and Pathology, National Research Council, Rome, Italy., Desideri M; Preclinical Models and New Therapeutic Agents Unit, IRCCS Regina Elena National Cancer Institute, Rome, Italy., Valentini E; Preclinical Models and New Therapeutic Agents Unit, IRCCS Regina Elena National Cancer Institute, Rome, Italy., D'Aguanno S; Preclinical Models and New Therapeutic Agents Unit, IRCCS Regina Elena National Cancer Institute, Rome, Italy., Tupone MG; Preclinical Models and New Therapeutic Agents Unit, IRCCS Regina Elena National Cancer Institute, Rome, Italy.; Department of Life, Health and Environmental Sciences, University of L'Aquila, L'Aquila, Italy., Buglioni S; Pathology Unit, IRCCS Regina Elena National Cancer Institute, Rome, Italy., Ercolani C; Pathology Unit, IRCCS Regina Elena National Cancer Institute, Rome, Italy., Gallo E; Pathology Unit, IRCCS Regina Elena National Cancer Institute, Rome, Italy., Amadio B; SAFU Unit, IRCCS Regina Elena National Cancer Institute, Rome, Italy., Terrenato I; Biostatistics and Bioinformatic Unit-Scientific Direction, IRCCS Regina Elena National Cancer Institute, Rome, Italy., Foddai ML; Immunohematology and Transfusional Medicine Unit, IRCCS Regina Elena National Cancer Institute, Rome, Italy., Sica A; Molecular Immunology Lab, Humanitas Clinical and Research Center, Milan, Italy donatella.delbufalo@ifo.gov.it antonio.sica@humanitasresearch.it.; Department of Pharmaceutical Sciences, Università del Piemonte Orientale 'Amedeo Avogadro', Novara, Italy., Del Bufalo D; Preclinical Models and New Therapeutic Agents Unit, IRCCS Regina Elena National Cancer Institute, Rome, Italy donatella.delbufalo@ifo.gov.it antonio.sica@humanitasresearch.it.

Publikováno v: Journal for immunotherapy of cancer [J Immunother Cancer] 2020 Apr; Vol. 8 (1).

Myeloid-Derived Suppressor Cells: Ductile Targets in Disease.

Autor: Consonni FM; Humanitas Clinical and Research Center, Rozzano, Italy., Porta C; Department of Pharmaceutical Sciences, Università del Piemonte Orientale 'Amedeo Avogadro', Novara, Italy.; Center for Translational Research on Autoimmune and Allergic Diseases (CAAD), University of Piemonte Orientale, Novara, Italy., Marino A; Department of Pharmaceutical Sciences, Università del Piemonte Orientale 'Amedeo Avogadro', Novara, Italy., Pandolfo C; Department of Pharmaceutical Sciences, Università del Piemonte Orientale 'Amedeo Avogadro', Novara, Italy., Mola S; Department of Pharmaceutical Sciences, Università del Piemonte Orientale 'Amedeo Avogadro', Novara, Italy.; Center for Translational Research on Autoimmune and Allergic Diseases (CAAD), University of Piemonte Orientale, Novara, Italy., Bleve A; Department of Pharmaceutical Sciences, Università del Piemonte Orientale 'Amedeo Avogadro', Novara, Italy., Sica A; Humanitas Clinical and Research Center, Rozzano, Italy.; Department of Pharmaceutical Sciences, Università del Piemonte Orientale 'Amedeo Avogadro', Novara, Italy.

Publikováno v: Frontiers in immunology [Front Immunol] 2019 May 03; Vol. 10, pp. 949. Date of Electronic Publication: 2019 May 03 (Print Publication: 2019).