Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Conrado Soria"'
Publikováno v:
Nature. 614:E29-E29
Autor:
Kelly B Engel, Scott Jewell, Rachana Agarwal, Thèrése Bocklage, Mary Barcus, Chih-Jian Lih, Sarah R. Greytak, Philip A Branton, Michael C. Sachs, Ping Guan, P. Mickey Williams, Leslie H. Sobin, Latarsha J. Carithers, Benjamin Fombonne, Rajiv Dhir, Helen M. Moore, Conrado Soria, Chris Andry, Elizabeth R. Duffy, Nancy Roche, Hana Odeh, Gabriel Sica
Publikováno v:
Archives of Pathology & Laboratory Medicine. 143:1106-1118
Context.—Despite widespread use of formalin-fixed, paraffin-embedded (FFPE) tissue in clinical and research settings, potential effects of variable tissue processing remain largely unknown.Objective.—To elucidate molecular effects associated with
Autor:
Roger Y. Tsien, Thomas J. Deerinck, Horng D. Ou, Andrew May, Colin J. Powers, Xiaokun Shu, Andrew B. Noske, James A. J. Fitzpatrick, Mark H. Ellisman, Clodagh C. O’Shea, Conrado Soria, Jeff A. Long, Hannah S. Land, Katie Y. Blain, Witek Kwiatkowski, Senyon Choe
Publikováno v:
Cell, vol 151, iss 2
Summary Evolution of minimal DNA tumor virus' genomes has selected for small viral oncoproteins that hijack critical cellular protein interaction networks. The structural basis for the multiple and dominant functions of adenovirus oncoproteins has re
Publikováno v:
Cancer Cell. 8:61-74
SummaryONYX-015 is an E1B-55K-deleted adenovirus that has promising clinical activity as a cancer therapy. However, many tumor cells fail to support ONYX-015 oncolytic replication. E1B-55K functions include p53 degradation, RNA export, and host prote
Autor:
John Kunich, Serah Choi, Kusum Pandey, Larry Boyle, Bridget Bagus, Yuqiao Shen, Gaston Habets, Frank McCormick, Conrado Soria, Dave Ginzinger, Annie Shen, Clodagh C. O’Shea, Cory R. Nicholas, Leisa Johnson
Publikováno v:
Cancer Cell. 6(6):611-623
ONYX-015 is an adenovirus that lacks the E1B-55K gene product for p53 degradation. Thus, ONYX-015 was conceived as an oncolytic virus that would selectively replicate in p53-defective tumor cells. Here we show that loss of E1B-55K leads to the induct
Autor:
Rachana Agarwal, Michael C. Sachs, Ping Guan, Dana R. Valley, Mickey Williams, Leslie H. Sobin, Robin Burges, Conrado Soria, Jewell Scott, Philip A. Branton, Latarsha J. Carithers, Corinne Camalier, Nancy Roche, Mary Barcus, Helen Moore, Hana Odeh, Kimberly M. Valentino, Biswajit Das, Anna M. Smith, Jason Lih, Jasmin H. Bavarva, Daniel C. Rohrer
Publikováno v:
Cancer Research. 76:1377-1377
The Biospecimen Pre-analytical Variables (BPV) Program of the Biorepositories and Biospecimen Research Branch (BBRB) at the National Cancer Institute (NCI) is designed to systematically investigate the effects of preanalytical factors on the molecula
Publikováno v:
Nature
The transcription factor p53 (also known as TP53) guards against tumour and virus replication and is inactivated in almost all cancers. p53-activated transcription of target genes is thought to be synonymous with the stabilization of p53 in response
Publikováno v:
Breast Cancer Research : BCR
Cancer is the second leading cause of death in the United States. Traditional treatments for cancer, such as radiation and chemotherapy, are frequently ineffective and are often associated with painful side effects that diminish the quality of life f
Adenoviral proteins mimic nutrient/growth signals to activate the mTOR pathway for viral replication
Autor:
Serah Choi, Jerry Shen, Kristina Klupsch, Conrado Soria, David Stokoe, Bridget Bagus, Clodagh C. O’Shea, Frank McCormick
Like tumor cells, DNA viruses have had to evolve mechanisms that uncouple cellular replication from the many intra- and extracellular factors that normally control it. Here we show that adenovirus encodes two proteins that activate the mammalian targ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e670de9a32a966eb72ab3e75e5f9c4f4
https://europepmc.org/articles/PMC556401/
https://europepmc.org/articles/PMC556401/
Autor:
Carine Bossard, Dinorah Friedmann-Morvinski, Conrado Soria, Clodagh C. O’Shea, Alma L. Burlingame, Kristen C. Espantman, Robert J. Chalkley, Inder M. Verma
Publikováno v:
Cancer Research. 71:4061-4061
Exploring the interactions between DNA viral and cellular proteins has revealed critical tumor target such as p53, E2F, and PI-3 kinase. Using a genetic approach, we have discovered that an adenoviral protein, E4-ORF3, dominantly suppresses p53 activ