Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Conrado Pascual"'
Publikováno v:
Comprehensive Psychoneuroendocrinology, Vol 11, Iss , Pp 100143- (2022)
Prenatal exposure to drugs of abuse results in neonatal abstinence syndrome (NAS). NAS causes significant morbidity and is associated with costly and lengthy hospitalization. Current pharmacotherapy is suboptimal with no FDA approved treatments. We e
Externí odkaz:
https://doaj.org/article/fb1e39e314c44667a88275c541c954fe
Autor:
Medha J. Gunaratna, Duy H. Hua, Bende Zou, Conrado Pascual, William Cao, Man Zhang, Sahani Weerasekara, Thi D. T. Nguyen, Kui Xiao, Xinmin Simon Xie
Publikováno v:
ARKIVOC, Vol 2019, Iss 3, Pp 22-39 (2019)
Externí odkaz:
https://doaj.org/article/50175da45b5a4384a6deacf74e35d5b3
Autor:
Bende Zou, Kui Xiao, Thi D.T. Nguyen, Xinmin Simon Xie, Sahani Weerasekara, Duy H. Hua, Medha J. Gunaratna, Conrado Pascual, Man Zhang, William S. Cao
Publikováno v:
ARKIVOC, Vol 2019, Iss 3, Pp 22-39 (2019)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::355c97a8b722b7815bdeb5d4c0f1a02c
https://doi.org/10.24820/ark.5550190.p010.752
https://doi.org/10.24820/ark.5550190.p010.752
Publikováno v:
The FASEB Journal. 35
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3775bcf22701a8a99957bbbf9ad5b9af
https://doi.org/10.1096/fasebj.2021.35.s1.04997
https://doi.org/10.1096/fasebj.2021.35.s1.04997
Autor:
Serkan Koldas, Sahani Weerasekara, Duy H. Hua, Medha J. Gunaratna, Xinmin Simon Xie, William S. Cao, Bende Zou, Man Zhang, Conrado Pascual, Zongbo Tong, Thi D.T. Nguyen
Publikováno v:
Heterocycles
Neuropathic pain, epilepsy, insomnia, and tremor disorder may arrive from an increase of intracellular Ca(2+) concentration through a dysfunction of T-type Ca(2+) channels. Thus, T-type calcium channels could be a target in drug discovery for the tre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e303d97f1b3d3d381654e02fd5ad88ea
https://pubmed.ncbi.nlm.nih.gov/32773946
https://pubmed.ncbi.nlm.nih.gov/32773946
Autor:
Lee-Way Jin, Xinmin Simon Xie, Conrado Pascual, Man Zhang, Jacopo Di Lucente, William S. Cao, Sahani Weerasekara, Bende Zou, Izumi Maezawa, Duy H. Hua
Publikováno v:
Journal of Alzheimer's Disease
Journal of Alzheimer's disease : JAD, vol 58, iss 2
Journal of Alzheimer's disease : JAD, vol 58, iss 2
There is an urgent unmet need for new therapeutics for Alzheimer's disease (AD), the most common cause of dementia in the elderly. Therapeutic approaches targeting amyloid-β (Aβ) and its downstream toxicities have become major strategies in AD drug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9aebdaf684f8c36557a63ffcae8b115d
http://europepmc.org/articles/PMC5438482
http://europepmc.org/articles/PMC5438482
Autor:
William H. Frey, Dean S. Carson, Jason M. Cuellar, Neil A. Manering, Daniel I. Jacobs, Michael Klukinov, Martin S. Angst, Yanli Qiao, Alexander Tzabazis, Allon Jacobs, James E. Miller, Conrado Pascual, Jordan Mechanic, David C. Yeomans
Publikováno v:
Cephalalgia. 36:943-950
Aims Our studies investigated the location of oxytocin receptors in the peripheral trigeminal sensory system and determined their role in trigeminal pain. Methods Oxytocin receptor expression and co-localization with calcitonin gene-related peptide w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd63ec297f32ba6cc8969d1d92abf159
https://doi.org/10.1177/0333102415618615
https://doi.org/10.1177/0333102415618615
Autor:
Zhiwei Guan, Kui Xiao, Xinmin Simon Xie, Julian Xie, Jidong Fang, Jingxi Zhang, C. David Weaver, Bende Zou, Conrado Pascual, William S. Cao, Craig W. Lindsley, Frank Kayser, James Xie
Publikováno v:
Sleep. 42
STUDY OBJECTIVES: A major challenge in treating insomnia is to find effective medicines with fewer side effects. Activation of G-protein-gated inward rectifying K(+) channels (GIRKs) by GABA(B) agonists baclofen or γ-hydroxybutyric acid (GHB) promot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec1660ad1f5c6f54799d789632de9623
https://doi.org/10.1093/sleep/zsy244
https://doi.org/10.1093/sleep/zsy244
Autor:
Roberto Ciccocioppo, Jinhua Wu, Daniela Mercatelli, Jennifer Schoch, Dennis Yasuda, Xinmin Simon Xie, Taline V. Khroyan, Conrado Pascual, Kelly A. Gaiolini, Andrea Cippitelli, Nurulain T. Zaveri, Alejandra Ramirez, Michelle Gorman, Lawrence Toll
Publikováno v:
British Journal of Pharmacology. 172:1834-1845
Background and Purpose The α3β4 subtype of nicotinic acetylcholine receptors (nAChRs) has been implicated in mediating nicotine reinforcement processes. AT-1001 has been recently described as a high-affinity and selective α3β4 nAChR antagonist th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1c61a96bc0fae7078b0ee3fa5dd51faa
https://doi.org/10.1111/bph.13034
https://doi.org/10.1111/bph.13034
Autor:
Jason M. Cuellar, David C. Yeomans, Alexander Tzabazis, James E. Miller, Neil A. Manering, Egilius L.H. Spierings, William H. Frey, Michael Klukinov, Shashi H. Kori, Conrado Pascual, Leah R. Hanson, Martin S. Angst, Daniel I. Jacobs, Dean S. Carson, Jordan Mechanic
Publikováno v:
Headache. 57
This article reviews material presented at the 2016 Scottsdale Headache Symposium. This presentation provided scientific results and rationale for the use of intranasal oxytocin for the treatment of migraine headache. Results from preclinical experim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ee3dbc8137bb2212e9f065d020c395c
https://pubmed.ncbi.nlm.nih.gov/28485846
https://pubmed.ncbi.nlm.nih.gov/28485846