Výsledky vyhledávání - "Conrad T Pfeiffer"

Spiroligomer‐Based Macrocycles for Atomically Precise Membranes

Autor: Yihui Xie, Danni Luo, Jesse A. Wiener, Alexander B. Koval, Conrad T. Pfeiffer, Christian E. Schafmeister

Publikováno v: Angewandte Chemie International Edition.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52f60aabd7beec413142844abf3df058
https://doi.org/10.1002/anie.202302809

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Mapping Angiotensin II Type 1 Receptor-Biased Signaling Using Proximity Labeling and Proteomics Identifies Diverse Actions of Biased Agonists

Autor: Steven P. Gygi, Howard A. Rockman, Joao A. Paulo, Jialu Wang, Conrad T Pfeiffer, Xue Jiang

Publikováno v: J Proteome Res

Angiotensin II type 1 receptors (AT1Rs) are one of the most widely studied G-protein-coupled receptors. To fully appreciate the diversity in cellular signaling profiles activated by AT1R transducer-biased ligands, we utilized peroxidase-catalyzed pro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c81f3cb2ce6efbe9d9f0151fd33e83cd
https://doi.org/10.1021/acs.jproteome.1c00080

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Proximity labeling for investigating protein-protein interactions

Autor: Conrad T. Pfeiffer, Joao A. Paulo, Steven P. Gygi, Howard A. Rockman

Publikováno v: Biomolecular Interactions Part B ISBN: 9780128233535

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5b02679eedb795be2d1722a0a644c3f0
https://doi.org/10.1016/bs.mcb.2021.12.006

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Abstract MP133: Development of β-arrestin-biased Positive Allosteric Modulators for the β 1 Adrenergic Receptor

Autor: Seungkirl Ahn, William Tian, Biswaranjan Pani, Jialu Wang, Robert J. Lefkowitz, Haoran Jiang, Howard A. Rockman, Conrad T Pfeiffer, Ilhan Gokhan, Xinyu Xiong, Alem W. Kahsai

Publikováno v: Circulation Research. 127

The β 1 adrenergic receptor (β 1 AR) is a central regulator of cardiac function and an important therapeutic target for cardiac diseases. Two emerging areas of receptor biology are biased agonism: ligand directed selective engagement of a receptor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::649c6aa1bcef23f3edced459289b50a0
https://doi.org/10.1161/res.127.suppl_1.mp133

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Utilization of the p-nitrobenzyloxycarbonyl (pNZ) amine protecting group and pentafluorophenyl (Pfp) esters for the solid phase synthesis of spiroligomers

Autor: Conrad T. Pfeiffer, Jae Eun Cheong, Justin D. Northrup, Matthew F.L. Parker, Melody A. Pham, Christian E. Schafmeister

Publikováno v: Tetrahedron Letters. 59:2884-2888

Spiroligomers are a class of peptidomimetics that connect interchangeable, stereochemically pure, cyclic monomers through pairs of amide bonds to form diketopiperazines between the monomers. This enables them to adopt predictable and programmable str

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::795eb7e22e84dd435b8048dab1cd3f9d
https://doi.org/10.1016/j.tetlet.2018.05.041

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An improved, scalable synthesis of bis-amino acids

Autor: Justin D. Northrup, Conrad T. Pfeiffer, Matthew F.L. Parker, Jae Eun Cheong, Christian E. Schafmeister

Publikováno v: Tetrahedron Letters. 57:4882-4884

trans-4-Hydroxy-l-proline derived bis-amino acids are chiral, cyclic building blocks that display two alpha-amino acids that are differentiated from each other with protecting groups. They are assembled into spiroligomers—rigid, shape-programmable

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e6f544b7a8fec6f6c9b167da7bcafd8b
https://doi.org/10.1016/j.tetlet.2016.09.032

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Determination of Internal Energy Distributions of Laser Electrospray Mass Spectrometry using Thermometer Ions and Other Biomolecules

Autor: Paul M. Flanigan, Robert J. Levis, Christian E. Schafmeister, Conrad T. Pfeiffer, Santosh Karki, Johnny J. Perez, Fengjian Shi

Publikováno v: Journal of the American Society for Mass Spectrometry. 25:1572-1582

The internal energy distributions for dried and liquid samples that were vaporized with femtosecond duration laser pulses centered at 800 nm and postionized by electrospray ionization-mass spectrometry (LEMS) were measured and compared with conventio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdab9e7f7277861a876f31b58571aea8
https://doi.org/10.1007/s13361-014-0936-6

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Solid Phase Synthesis of a Functionalized Bis-Peptide Using 'Safety Catch' Methodology

Autor: Conrad T. Pfeiffer, Christian E. Schafmeister

Publikováno v: Journal of Visualized Experiments.

In 1962, R.B. Merrifield published the first procedure using solid-phase peptide synthesis as a novel route to efficiently synthesize peptides. This technique quickly proved advantageous over its solution-phase predecessor in both time and labor. Imp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46320bd0d966c3493f703dae2a035fcb
https://doi.org/10.3791/4112-v

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