Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Conrad N. Trumbore"'
Publikováno v:
Journal of Alzheimer's Disease. 90:33-59
This paper suggests a chemical mechanism for the earliest stages of Alzheimer’s disease (AD). Cerebrospinal fluid (CSF) flow stresses provide the energy needed to induce molecular conformation changes leading to AD by initiating amyloid-β (Aβ) an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::390ccd4ac3a7a9cd424ba667c01c0b58
https://doi.org/10.3233/jad-220622
https://doi.org/10.3233/jad-220622
Autor:
Conrad N. Trumbore
Publikováno v:
Journal of Alzheimer's Disease
Amyloid-β (Aβ) and tau oligomers have been identified as neurotoxic agents responsible for causing Alzheimer’s disease (AD). Clinical trials using Aβ and tau as targets have failed, giving rise to calls for new research approaches to combat AD.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f165c4af0b528be28146931bdcbd3738
https://doi.org/10.3233/jad-201025
https://doi.org/10.3233/jad-201025
Publikováno v:
Journal of Alzheimer's Disease
Amyloid-β (Aβ) solution injections into an aqueous mobile phase moving through narrow bore stainless-steel capillary tubing results in adsorption of at least 99% Aβ within the tubing or injection valve. However, if flow is stopped for a period of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ba8bbda8c00bcb02809ed1e7ac17a29
https://doi.org/10.3233/jad-190522
https://doi.org/10.3233/jad-190522
Autor:
Conrad N. Trumbore
Publikováno v:
Journal of Alzheimer's Disease
Amyloid-β oligomers (AβO) have been proposed as neurotoxins in the synaptic dysfunction that precedes Alzheimer's disease symptoms. Human and animal model studies report that senile plaques contain a halo of AβO molecules surrounding these plaques
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97431f93dc7653aa6b124d9b5c52306a
http://europepmc.org/articles/PMC6294594
http://europepmc.org/articles/PMC6294594
Autor:
Conrad N. Trumbore
Publikováno v:
Journal of Alzheimer's Disease
If cerebrospinal and interstitial fluids move through very narrow brain flow channels, these restrictive surroundings generate varying levels of fluid shear and different shear rates, and dissolved amyloid monomers absorb different shear energies. It
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6ada46528e24ed005672f3dfb3bb3cf
https://doi.org/10.3233/jad-171003
https://doi.org/10.3233/jad-171003
Autor:
Conrad N. Trumbore
Publikováno v:
Journal of Alzheimer's Disease
Liquid sheared amyloid-β (Aβ) initiates amyloid cascade reactions, producing unstable, potentially toxic oligomers. There is a need for new analytical tools with which to study these oligomers. A very small bore capillary flow system is proposed as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fa2dfe8594656dc51822ff9dc7aab18
https://doi.org/10.3233/jad-170259
https://doi.org/10.3233/jad-170259
Autor:
Conrad N, Trumbore
Publikováno v:
Progress in molecular biology and translational science. 166
The IDP amyloid β-protein (Aβ) has been both the prime causative suspect and drug development target in the fight against Alzheimer's disease (AD). Unfortunately, all clinical trials against Aβ based on this assumption have failed. This review pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4db2eb9c4d47adf05a4613d5884052b0
https://pubmed.ncbi.nlm.nih.gov/31521233
https://pubmed.ncbi.nlm.nih.gov/31521233
Autor:
Conrad N. Trumbore
The IDP amyloid β-protein (Aβ) has been both the prime causative suspect and drug development target in the fight against Alzheimer's disease (AD). Unfortunately, all clinical trials against Aβ based on this assumption have failed. This review pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9c478ba727bb5f1ec1cfc06e81439063
https://doi.org/10.1016/bs.pmbts.2019.05.008
https://doi.org/10.1016/bs.pmbts.2019.05.008
Publikováno v:
Radiation Research. 155:453-465
Gamma irradiation of DNA solutions containing copper causes changes in DNA conformation in oligonucleotides and in natural and synthetic DNAs. Diagnostic for these conformational changes is a ubiquitous 187-nm peak in the circular dichroism (CD) diff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d35ecd00038a95085c97abb7c06144c6
https://doi.org/10.1667/0033-7587(2001)155[0453:cidcib]2.0.co
https://doi.org/10.1667/0033-7587(2001)155[0453:cidcib]2.0.co
Publikováno v:
International Journal of Radiation Biology. 66:479-483
Metal-ion assisted, gamma-radiation-induced B-Z conformation changes have been observed with UV and circular dichroism spectroscopy for poly (dGdC), calf thymus and herring testis DNA. These conformational changes are similar to those induced by incr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45e9c60560079d4153e87f2ca1a51559
https://doi.org/10.1080/09553009414551491
https://doi.org/10.1080/09553009414551491