Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Conrad En-Zuo Chan"'
Autor:
Shivankari Krishnananthasivam, Hao Li, Rania Bouzeyen, Bhuvaneshwari Shunmuganathan, Kiren Purushotorman, Xinlei Liao, Fengjiao Du, Claudia Guldager Kring Friis, Felicity Crawshay-Williams, Low Heng Boon, Qian Xinlei, Conrad En Zuo Chan, Radoslaw Sobota, Mary Kozma, Valeria Barcelli, Guirong Wang, Hairong Huang, Andreas Floto, Pablo Bifani, Babak Javid, Paul A. MacAry
Publikováno v:
npj Vaccines, Vol 8, Iss 1, Pp 1-12 (2023)
Abstract Tuberculosis (TB) is an airborne disease caused by Mycobacterium tuberculosis (Mtb). Whilst a functional role for humoral immunity in Mtb protection remains poorly defined, previous studies have suggested that antibodies can contribute towar
Externí odkaz:
https://doaj.org/article/b24451097c804d2ba5f67b2d5c67eea3
Autor:
Saket Jhajharia, Fritz Lai, Heng Boon Low, Kiren Purushotorman, Bhuvaneshwari D/O Shunmuganathan, Conrad En Zuo Chan, Rachel Hammond, Hans-Jürgen Netter, Qingfeng Chen, Seng Gee Lim, Paul A. MacAry
Publikováno v:
npj Vaccines, Vol 7, Iss 1, Pp 1-9 (2022)
Abstract Hepatitis B Virus (HBV) is a hepadnavirus that is the principal pathogen underlying viral liver disease in human populations. In this study, we describe the isolation and characterization of a fully human monoclonal antibody for HBV. This Hu
Externí odkaz:
https://doaj.org/article/fb283a36a7c34a808b9658dccca347d5
Autor:
Agata Blasiak, Anh T. L. Truong, Alexandria Remus, Lissa Hooi, Shirley Gek Kheng Seah, Peter Wang, De Hoe Chye, Angeline Pei Chiew Lim, Kim Tien Ng, Swee Teng Teo, Yee-Joo Tan, David Michael Allen, Louis Yi Ann Chai, Wee Joo Chng, Raymond T. P. Lin, David C. B. Lye, John Eu-Li Wong, Gek-Yen Gladys Tan, Conrad En Zuo Chan, Edward Kai-Hua Chow, Dean Ho
Publikováno v:
npj Digital Medicine, Vol 5, Iss 1, Pp 1-12 (2022)
Abstract IDentif.AI-x, a clinically actionable artificial intelligence platform, was used to rapidly pinpoint and prioritize optimal combination therapies against COVID-19 by pairing a prospective, experimental validation of multi-drug efficacy on a
Externí odkaz:
https://doaj.org/article/523937a2d0914dc491cce1f3ee4e42c6
Autor:
Shivankari Krishnananthasivam, Hao Li, Rania Bouzeyen, Bhuvaneshwari Shunmuganathan, Kiren Purushotorman, Xinlei Liao, Fengjiao Du, Claudia Guldager Kring Friis, Felicity Crawshay-Williams, Low Heng Boon, Qian Xinlei, Conrad En Zuo Chan, Radoslaw Sobota, Mary Kozma, Valeria Barcelli, Guirong Wang, Hairong Huang, Andreas Floto, Pablo Bifani, Babak Javid, Paul A. MacAry
Publikováno v:
npj Vaccines, Vol 8, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/61f8a2d516d048cba436c52a464a71b5
Autor:
Conrad En-Zuo Chan, Ching-Ging Ng, Angeline Pei-Chew Lim, Shirley Lay-Kheng Seah, De-Hoe Chye, Steven Ka-Khuen Wong, Jie-Hui Lim, Vanessa Zi-Yun Lim, Soak-Kuan Lai, Pui-San Wong, Kok-Mun Leong, Yi-Chun Liu, Richard J. Sugrue, Boon-Huan Tan
Publikováno v:
Journal of Virology. 96
A human monoclonal antibody panel (PD4, PD5, PD7, SC23, and SC29) was isolated from the B cells of convalescent patients and used to examine the S protein in SARS-CoV-2-infected cells. While all five antibodies bound conformational-specific epitopes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ecf7e543845d9ae3806448ce0836308
https://doi.org/10.1128/jvi.00455-22
https://doi.org/10.1128/jvi.00455-22
Autor:
Brendon J. Hanson, Paul A. Macary, Markus R. Wenk, J. Ludovic Croxford, Amaury Cazenave-Gassiot, Yan Ting Lim, Conrad En Zuo Chan, Md. Omedul Islam
Publikováno v:
International Journal of Molecular Sciences, Vol 13, Iss 4, Pp 4937-4948 (2012)
The employment of monoclonal antibodies (Mabs) to identify disease-associated biomarkers in clinical samples represents the underlying principle for many diagnostic tests. To date, these have been principally developed for protein targets with few re
Externí odkaz:
https://doaj.org/article/a6f7cb576f284ac5abe9761d4b02fa50
Autor:
Agata Blasiak, Anh T. L. Truong, Alexandria Remus, Lissa Hooi, Shirley Gek Kheng Seah, Peter Wang, De Hoe Chye, Angeline Pei Chiew Lim, Kim Tien Ng, Swee Teng Teo, Yee-Joo Tan, David Michael Allen, Louis Yi Ann Chai, Wee Joo Chng, Raymond T. P. Lin, David C. B. Lye, John Eu-Li Wong, Gek-Yen Gladys Tan, Conrad En Zuo Chan, Edward Kai-Hua Chow, Dean Ho
Publikováno v:
NPJ digital medicine. 5(1)
IDentif.AI-x, a clinically actionable artificial intelligence platform, was used to rapidly pinpoint and prioritize optimal combination therapies against COVID-19 by pairing a prospective, experimental validation of multi-drug efficacy on a SARS-CoV-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d29235d08a7df65af2d238d72595e2b
https://pubmed.ncbi.nlm.nih.gov/35773329
https://pubmed.ncbi.nlm.nih.gov/35773329
Autor:
Conrad En-Zuo Chan, Ching-Ging Ng, Angeline Pei-Chew Lim, Shirley Lay-Kheng Seah, De-Hoe Chye, Steven Ka-Khuen Wong, Jie-Hui Lim, Vanessa Zi-Yun Lim, Soak-Kuan Lai, Pui-San Wong, Kok-Mun Leong, Yi-Chun Liu, Richard J Sugrue, Boon-Huan Tan
A human monoclonal antibody panel (PD4, PD5, PD7, SC23 and SC29) was isolated from the B cells of convalescent patients and used to examine the S protein in SARS-CoV-2- infected cells. While all five antibodies bound conformational-specific epitopes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::21ad3dd6e3be64a5f34854fc60afdecb
https://doi.org/10.1101/2021.12.06.471528
https://doi.org/10.1101/2021.12.06.471528
Autor:
Conrad En Zuo Chan, Angeline Pei Chiew Lim, Annie Hoi Yi Chan, Paul A MacAry, Brendon John Hanson
Publikováno v:
PLoS ONE, Vol 5, Iss 4, p e10261 (2010)
Multi-polypeptide proteins such as antibodies are difficult to express in prokaryotic systems such as E. coli due to the complexity of protein folding plus secretion. Thus far, proprietary strains or fermenter cultures have been required for apprecia
Externí odkaz:
https://doaj.org/article/58099bd193d040faad6fd74ed667d50e