Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Conrad E.Z. Chan"'
Autor:
Agata Blasiak, Anh T. L. Truong, Peter Wang, Lissa Hooi, De Hoe Chye, Shi-Bei Tan, Kui You, Alexandria Remus, David Michael Allen, Louis Yi Ann Chai, Conrad E.Z. Chan, David C. B. Lye, Gek-Yen G. Tan, Shirley G. K. Seah, Edward Kai-Hua Chow, Dean Ho
Publikováno v:
ACS Nano. 16:15141-15154
Nanomedicine-based and unmodified drug interventions to address COVID-19 have evolved over the course of the pandemic as more information is gleaned and virus variants continue to emerge. For example, some early therapies (e.g., antibodies) have expe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbd506e481c6e9e0142c387b69d89602
https://doi.org/10.1021/acsnano.2c06366
https://doi.org/10.1021/acsnano.2c06366
Autor:
David M Allen, Gek-Yen Gladys Tan, Peter Wang, Alexandria Remus, Anh T. L. Truong, Yee-Joo Tan, Raymond T. P. Lin, Agata Blasiak, Edward Kai-Hua Chow, Wee Joo Chng, Kim Tien Ng, Angeline Pei Chiew Lim, Louis Yi Ann Chai, De Hoe Chye, Dean Ho, John Wong, Conrad E.Z. Chan, David C. Lye, Swee Teng Teo, Shirley Gek Kheng Seah, Lissa Hooi
ObjectivesWe aimed to harness IDentif.AI 2.0, a clinically actionable AI platform to rapidly pinpoint and prioritize optimal combination therapy regimens against COVID-19.MethodsA pool of starting candidate therapies was developed in collaboration wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3657e0b9e1d56a1030e8d79de9129c4c
https://doi.org/10.1101/2021.06.23.21259321
https://doi.org/10.1101/2021.06.23.21259321
Autor:
Julien Lescar, Angeline T. H. Goh, Yee Hwa Wong, Rachel Zui Chih Teo, Jiawei Yap, Abbas El Sahili, Maryam Hamidinia, Kathryn J. Wood, Conrad E.Z. Chan, Nicholas R. J. Gascoigne, Tanusya M. Murali, Kiren Purushotorman, Brendon J. Hanson, Chong Wai Liew, Chien Tei Too, Anantharaman Vathsala, Yue Gu, Paul A. MacAry
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Nature Communications
Nature Communications
Our understanding of the conformational and electrostatic determinants that underlie targeting of human leukocyte antigens (HLA) by anti-HLA alloantibodies is principally based upon in silico modelling. Here we provide a biochemical/biophysical and f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a12f0fbf74a9110ef580a79127b5631
https://doaj.org/article/d43685122a4b496da7e60656bb9c199a
https://doaj.org/article/d43685122a4b496da7e60656bb9c199a
Autor:
Chien-Te K Tseng, Dipti Thakkar, Boyd-Kirkup Jerome Douglas, Trevor Brasel, Paul A. MacAry, Dong Ling Wang, Jason E. Comer, Hannes Hentze, Ingram Piers, Brendon J. Hanson, Angeline P.C. Lim, Guan Siyu, Maricela Torres, Kiren Purushotorman, Damian O’Connell, Jacklyn J.Y. Neo, Guo Hui Teo, Steven K.K. Wong, Conrad E.Z. Chan, Shirley Gek Kheng Seah, Venkateshan S. Prativadibhayankara, Paul Edward Hutchinson, De Hoe Chye, Jenny G. Low, Gary S.L. Loh, Kantharaj Ethirajulu, David C. Lye, Jie Hui Lim, Pui San Wong, Barnaby Edward Young, Alan D.T. Barrett, Shane Massey
SARS-CoV-2-neutralizing antibodies are promising therapeutics for COVID-19. However, little is known about the mechanisms of action of these antibodies or their effective dosing windows. We report the discovery and development of SC31, a potent SARS-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::606850ac3cb09b13cecd9961dbe2c00e
https://doi.org/10.1101/2020.10.26.355107
https://doi.org/10.1101/2020.10.26.355107
Autor:
Edward Kai-Hua Chow, Theodore Kee, De Hoe Chye, Lissa Hooi, Dean Ho, Nguyen Le, Shirley Gek Kheng Seah, Xianting Ding, Rishi J. Desai, Pui San Wong, Alexandria Remus, Brendon J. Hanson, Jhin Jieh Lim, Agata Blasiak, Anh T. L. Truong, Conrad E.Z. Chan
The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and coronavirus disease 2019 (COVID-19) has led to the rapid initiation of urgently needed clinical trials of repurposed drug combinations and monotherapies. These regimens
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2567ef110059affc2d73c8007fff9239
https://doi.org/10.1101/2020.05.04.20088104
https://doi.org/10.1101/2020.05.04.20088104
Autor:
Jie Hui Lim, Pui San Wong, Steven K.K. Wong, Chien Te K. Tseng, Guan Siyu, Paul A. MacAry, Shane Massey, Shirley Gek Kheng Seah, Alan D.T. Barrett, Dipti Thakkar, Jenny G. Low, Guo Hui Teo, Kantharaj Ethirajulu, Jason E. Comer, Brendon J. Hanson, Boyd-Kirkup Jerome Douglas, Ingram Piers, Venkateshan S. Prativadibhayankara, Barnaby Edward Young, Trevor Brasel, Angeline P.C. Lim, Hannes Hentze, Maricela Torres, Dongling Wang, Kiren Purushotorman, Jacklyn J.Y. Neo, Conrad E.Z. Chan, De Hoe Chye, Paul Edward Hutchinson, Gary S.L. Loh
Publikováno v:
PLoS ONE, Vol 16, Iss 6, p e0253487 (2021)
PLoS ONE
PLoS ONE
Although SARS-CoV-2-neutralizing antibodies are promising therapeutics against COVID-19, little is known about their mechanism(s) of action or effective dosing windows. We report the generation and development of SC31, a potent SARS-CoV-2 neutralizin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b552438306ce977645ca8b0816814c54
https://doi.org/10.1371/journal.pone.0253487
https://doi.org/10.1371/journal.pone.0253487
Autor:
Irina Caminschi, Conrad E.Z. Chan, Ken Shortman, Anna Ker, Hae-Young Park, Sylvie Alonso, Ranmali Kavishna, Mireille H. Lahoud, Brendon J. Hanson, Peck Szee Tan, Jinhua Lu, Paul A. MacAry
Publikováno v:
npj Vaccines, Vol 2, Iss 1, Pp 1-11 (2017)
NPJ Vaccines
NPJ Vaccines
Targeting model antigens (Ags) to Clec9A on DC has been shown to induce, not only cytotoxic T cells, but also high levels of Ab. In fact, Ab responses against immunogenic Ag were effectively generated even in the absence of DC-activating adjuvants. H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::138ef7c24d10d06740a071dc14e6403f
http://link.springer.com/article/10.1038/s41541-017-0033-5
http://link.springer.com/article/10.1038/s41541-017-0033-5
Autor:
Manuel Adrian Suter, Nicholas R. J. Gascoigne, Chien Tei Too, Min Zin Oo, Conrad E.Z. Chan, Junyun Lai, Wei Jian Tan, Andrew Guo Xian Lim, Brendon J. Hanson, Soh Ha Chan, Joanna Ai Ling Choo, Paul A. MacAry, Fatimah Bte Mustafa, Nalini Srinivasan, Youjia Zhong
Publikováno v:
Scientific Reports
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Epstein-Barr virus (EBV) is a common gammaherpesvirus associated with various human malignancies. Antibodies with T cell receptor-like specificities (TCR-like mAbs) provide a means to target intracellular tumor- or virus-associated antigens by recogn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22e5a0826188fdc3947ea66c6b0c327a
https://pubmed.ncbi.nlm.nih.gov/28855662
https://pubmed.ncbi.nlm.nih.gov/28855662
Publikováno v:
International Immunology
Using phage-display to discover and isolate therapeutic antibodies
Phage display involves the expression of selected proteins on the surface of filamentous phage through fusion with phage coat protein, with the genetic sequence packaged within,
Phage display involves the expression of selected proteins on the surface of filamentous phage through fusion with phage coat protein, with the genetic sequence packaged within,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2c4ba30db64857cc66cbfd26e322434
https://doi.org/10.1093/intimm/dxu082
https://doi.org/10.1093/intimm/dxu082
Autor:
Conrad E.Z. Chan, Paul A. MacAry, Markus R. Wenk, Shyue-Wei Pang, Bryan Z. Zhao, Anne K. Bendt, Amaury Cazenave-Gassiot, Brendon J. Hanson
Publikováno v:
Journal of Lipid Research, Vol 54, Iss 10, Pp 2924-2932 (2013)
Tuberculosis is a major cause of mortality and morbidity due to infectious disease. However, current clinical diagnostic methodologies such as PCR, sputum culture, or smear microscopy are not ideal. Antibody-based assays are a suitable alternative bu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46bbe0b96d6c7e306735ee73acf45c54
http://www.sciencedirect.com/science/article/pii/S0022227520353189
http://www.sciencedirect.com/science/article/pii/S0022227520353189