Inhibition of p38 signaling curtails the SARS-CoV-2 induced inflammatory response but retains the IFN-dependent antiviral defense of the lung epithelial barrier.

Autor: Faist A; Institute of Virology (IVM), University Hospital Muenster, University of Muenster, Muenster, Germany; CiM-IMPRS, University of Muenster, Cells in Motion-International Max Planck Research School - Molecular Biomedicine, Muenster, Germany., Schloer S; Research Group 'Regulatory Mechanisms of Inflammation', Institute of Medical Biochemistry, Center for Molecular Biology of Inflammation, Germany; 'Cells in Motion' Interfaculty Center, University of Muenster, Muenster, Germany; Leibniz Institute for Experimental Virology, Hamburg, Germany., Mecate-Zambrano A; Institute of Virology (IVM), University Hospital Muenster, University of Muenster, Muenster, Germany; Interdisciplinary Centre for Clinical Research, Medical Faculty, University of Muenster, Muenster, Germany., Janowski J; Institute of Virology (IVM), University Hospital Muenster, University of Muenster, Muenster, Germany., Schreiber A; Institute of Virology (IVM), University Hospital Muenster, University of Muenster, Muenster, Germany., Boergeling Y; Institute of Virology (IVM), University Hospital Muenster, University of Muenster, Muenster, Germany; Interdisciplinary Centre for Clinical Research, Medical Faculty, University of Muenster, Muenster, Germany., Conrad BCG; Institute of Virology (IVM), University Hospital Muenster, University of Muenster, Muenster, Germany., Kumar S; Institute of Virology (IVM), University Hospital Muenster, University of Muenster, Muenster, Germany; EvoPAD Research Training Group 2220, University of Muenster, Muenster, Germany., Toebben L; Institute of Virology (IVM), University Hospital Muenster, University of Muenster, Muenster, Germany., Schughart K; Department of Infection Genetics, Helmholtz Centre for Infection Research, Braunschweig, Germany; University of Veterinary Medicine Hannover, Hannover, Germany; Department of Microbiology, Immunology and Biochemistry, University of Tennessee Health Science Center, Memphis, TN, USA., Baumgardt M; Department for Infectious Diseases and Respiratory Medicine, Charité - Universitätsmedizin Berlin, Corporate Member of the Freie Universität Berlin, Humboldt-University Berlin and Berlin Institute of Health, Berlin, Germany., Kessler M; Department for Infectious Diseases and Respiratory Medicine, Charité - Universitätsmedizin Berlin, Corporate Member of the Freie Universität Berlin, Humboldt-University Berlin and Berlin Institute of Health, Berlin, Germany; Department of Gynecology and Obstetrics, Ludwig-Maximilians-University Munich, Munich, Germany., Hoenzke K; Department for Infectious Diseases and Respiratory Medicine, Charité - Universitätsmedizin Berlin, Corporate Member of the Freie Universität Berlin, Humboldt-University Berlin and Berlin Institute of Health, Berlin, Germany., Hocke A; Department for Infectious Diseases and Respiratory Medicine, Charité - Universitätsmedizin Berlin, Corporate Member of the Freie Universität Berlin, Humboldt-University Berlin and Berlin Institute of Health, Berlin, Germany., Trautmann M; Division of Translational Pathology, Gerhard-Domagk-Institute of Pathology, University Hospital Muenster, Muenster, Germany; Gerhard-Domagk-Institute of Pathology, University of Muenster, Muenster, Germany., Hartmann W; Division of Translational Pathology, Gerhard-Domagk-Institute of Pathology, University Hospital Muenster, Muenster, Germany; Gerhard-Domagk-Institute of Pathology, University of Muenster, Muenster, Germany., Kato H; Institute of Cardiovascular Immunology, University Hospital Bonn, University of Bonn, Bonn, Germany., Rescher U; Research Group 'Regulatory Mechanisms of Inflammation', Institute of Medical Biochemistry, Center for Molecular Biology of Inflammation, Germany; 'Cells in Motion' Interfaculty Center, University of Muenster, Muenster, Germany., Christersson A; Institute of Virology (IVM), University Hospital Muenster, University of Muenster, Muenster, Germany., Kuehn J; Institute of Virology (IVM), University Hospital Muenster, University of Muenster, Muenster, Germany., Mellmann A; Institute of Hygiene, University of Muenster, Muenster, Germany., Wolff T; Unit 17 'Influenza and Other Respiratory Viruses', Robert-Koch-Institute, Berlin, Germany., Kuempers P; Department of Medicine D, Division of General Internal and Emergency Medicine, Nephrology, and Rheumatology, University Hospital Muenster, Muenster, Germany., Rovas A; Department of Medicine D, Division of General Internal and Emergency Medicine, Nephrology, and Rheumatology, University Hospital Muenster, Muenster, Germany., Wiewrodt R; Department of Medicine A, University Hospital Muenster, Muenster, Germany; Department of Respiratory Medicine and Thoracic Oncology, Foundation Mathias Spital, Rheine and Ibbenbueren, Germany., Wiebe K; Department of Thoracic Surgery, University Hospital Muenster, Muenster, Germany., Barth P; Gerhard-Domagk-Institute of Pathology, University of Muenster, Muenster, Germany., Ludwig S; Institute of Virology (IVM), University Hospital Muenster, University of Muenster, Muenster, Germany; 'Cells in Motion' Interfaculty Center, University of Muenster, Muenster, Germany; Interdisciplinary Centre for Clinical Research, Medical Faculty, University of Muenster, Muenster, Germany; EvoPAD Research Training Group 2220, University of Muenster, Muenster, Germany., Brunotte L; Institute of Virology (IVM), University Hospital Muenster, University of Muenster, Muenster, Germany; Interdisciplinary Centre for Clinical Research, Medical Faculty, University of Muenster, Muenster, Germany. Electronic address: brunotte@uni-muenster.de.

Publikováno v: Antiviral research [Antiviral Res] 2023 Jan; Vol. 209, pp. 105475. Date of Electronic Publication: 2022 Nov 21.