Zobrazeno 1 - 10
of 72
pro vyhledávání: '"Conrad A Farrar"'
Autor:
Anastasia Polycarpou, Mark Howard, Conrad A Farrar, Roseanna Greenlaw, Giorgia Fanelli, Russell Wallis, Linda S Klavinskis, Steven Sacks
Publikováno v:
EMBO Molecular Medicine, Vol 12, Iss 8, Pp 1-15 (2020)
Abstract A novel coronavirus, SARS‐CoV‐2, has recently emerged in China and spread internationally, posing a health emergency to the global community. COVID‐19 caused by SARS‐CoV‐2 is associated with an acute respiratory illness that varies
Externí odkaz:
https://doaj.org/article/92ff360d09bb43c098725e7b4e0899cb
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
The complement system is a dynamic subset of the innate immune system, playing roles in host defense, clearance of immune complexes and cell debris, and priming the adaptive immune response. Over the last 40 years our understanding of the complement
Externí odkaz:
https://doaj.org/article/f9b4b1b245624313a54d81fcafcf7cc9
Publikováno v:
Seminars in Immunopathology
Until recently, the only known condition in which complement could mediate transplant injury was the rare occurrence of antibody-mediated rejection, in which the original concept of antibody immunity against the transplant was supported by complement
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5340bd8a4e10b3cf9c304b39d657e4e5
https://doi.org/10.1007/s00281-021-00896-3
https://doi.org/10.1007/s00281-021-00896-3
Autor:
Ke Li, Jia-Xing Wang, Nirmal K. Banda, Ang Li, Na Wang, Teng-Yue Diao, Dan Liu, Ning Ma, Jia-Yu Liu, Zongfang Li, Conrad A. Farrar, Rafael Bayarri-Olmos, Cui Qiang, Wuding Zhou, Xiao Yang, Li Xue, Weiju Wu, Peter Garred, Baojun Zhang, Kun-Yi Wu
Publikováno v:
Wang, N, Wu, W, Qiang, C, Ma, N, Wu, K, Liu, D, Wang, J X, Yang, X, Xue, L, Diao, T Y, Liu, J Y, Li, A, Zhang, B, Li, Z F, Farrar, C A, Banda, N K, Bayarri-Olmos, R, Garred, P, Zhou, W & Li, K 2021, ' Protective Role of Collectin 11 in a Mouse Model of Rheumatoid Arthritis ', Arthritis and Rheumatology, vol. 73, no. 8, pp. 1430-1440 . https://doi.org/10.1002/art.41696
Arthritis Rheumatol
Wang, N, Wu, W, Qiang, C, Ma, N, Wu, K, Liu, D, Wang, J, Yang, X, Xue, L, Diao, T, Liu, J, Li, A, Zhang, B, Li, Z, Farrar, C A, Banda, N K, Bayarri-olmos, R, Garred, P, Zhou, W & Li, K 2021, ' Protective Role of Collectin 11 in a Mouse Model of Rheumatoid Arthritis ', Arthritis and Rheumatology, vol. 73, no. 8, pp. 1430-1440 . https://doi.org/10.1002/art.41696
Arthritis Rheumatol
Wang, N, Wu, W, Qiang, C, Ma, N, Wu, K, Liu, D, Wang, J, Yang, X, Xue, L, Diao, T, Liu, J, Li, A, Zhang, B, Li, Z, Farrar, C A, Banda, N K, Bayarri-olmos, R, Garred, P, Zhou, W & Li, K 2021, ' Protective Role of Collectin 11 in a Mouse Model of Rheumatoid Arthritis ', Arthritis and Rheumatology, vol. 73, no. 8, pp. 1430-1440 . https://doi.org/10.1002/art.41696
Objective: Collectin 11 (CL-11) is a soluble C-type lectin, a mediator of innate immunity. Its role in autoimmune disorders is unknown. We undertook this study to determine the role of CL-11 in a mouse model of rheumatoid arthritis (RA). Methods: A m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fea9e9ad849ed40dc058b9cf42746c85
https://curis.ku.dk/portal/da/publications/protective-role-of-collectin-11-in-a-mouse-model-of-rheumatoid-arthritis(7db555d1-70d0-4c84-a9c7-305f761d2824).html
https://curis.ku.dk/portal/da/publications/protective-role-of-collectin-11-in-a-mouse-model-of-rheumatoid-arthritis(7db555d1-70d0-4c84-a9c7-305f761d2824).html
Autor:
Mark Howard, Roseanna Greenlaw, Conrad A. Farrar, Giorgia Fanelli, Russell Wallis, Anastasia Polycarpou, Steven H. Sacks, Linda S. Klavinskis
Publikováno v:
EMBO Molecular Medicine, Vol 12, Iss 8, Pp n/a-n/a (2020)
EMBO Molecular Medicine
EMBO Molecular Medicine
A novel coronavirus, SARS‐CoV‐2, has recently emerged in China and spread internationally, posing a health emergency to the global community. COVID‐19 caused by SARS‐CoV‐2 is associated with an acute respiratory illness that varies from mil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::135c56db5398dfde7ab23b17a5aa9445
https://doaj.org/article/92ff360d09bb43c098725e7b4e0899cb
https://doaj.org/article/92ff360d09bb43c098725e7b4e0899cb
Autor:
Steven H. Sacks, Conrad A. Farrar, Russell Wallis, Mark Christopher Howard, Christopher L Nauser
Publikováno v:
Howard, M C, Nauser, C L, Farrar, C A, Wallis, R & Sacks, S H 2020, ' l-Fucose prevention of renal ischaemia/reperfusion injury in Mice ', FASEB journal : official publication of the Federation of American Societies for Experimental Biology, vol. 34, no. 1, pp. 822-834 . https://doi.org/10.1096/fj.201901582R
The FASEB Journal
The FASEB Journal
In a recent study, we identified a fucosylated damage‐associated ligand exposed by ischemia on renal tubule epithelial cells, which after recognition by collectin‐11 (CL‐11 or collectin kidney 1 (CL‐K1)), initiates complement activation and a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::675d863bb5a8e8c7e687567f3a07c042
https://kclpure.kcl.ac.uk/en/publications/aa739049-ab34-4b10-8944-fbfe78a38d1d
https://kclpure.kcl.ac.uk/en/publications/aa739049-ab34-4b10-8944-fbfe78a38d1d
Autor:
Francesca Lucibello, Véronique Frémeaux-Bacchi, Conrad A. Farrar, Juliette Leon, Marie V. Daugan, Patrick Girardie, Pascale de Lonlay, Amandine Ydee, Lubka T. Roumenina, Caroline Rambaud, Romain Berthaud, Moglie Le Quintrec, Victoria Poillerat, Sophie Chauvet, Idris Boudhabhay, Peter Garred, Khalil El Karoui, Marion Rabant, Carine Torset, Anne Grunenwald, Marie Frimat, Viviane Gnemmi, Steven H. Sacks
Publikováno v:
Kidney International
Kidney International, In press, ⟨10.1016/j.kint.2020.09.033⟩
Kidney International, Nature Publishing Group, In press, ⟨10.1016/j.kint.2020.09.033⟩
Boudhabhay, I, Poillerat, V, Grunenwald, A, Torset, C, Leon, J, Daugan, M V, Lucibello, F, El Karoui, K, Ydee, A, Chauvet, S, Girardie, P, Sacks, S, Farrar, C A, Garred, P, Berthaud, R, Le Quintrec, M, Rabant, M, de Lonlay, P, Rambaud, C, Gnemmi, V, Fremeaux-Bacchi, V, Frimat, M & Roumenina, L T 2021, ' Complement activation is a crucial driver of acute kidney injury in rhabdomyolysis ', Kidney International, vol. 99, no. 3, pp. 581-597 . https://doi.org/10.1016/j.kint.2020.09.033
Kidney International, In press, ⟨10.1016/j.kint.2020.09.033⟩
Kidney International, Nature Publishing Group, In press, ⟨10.1016/j.kint.2020.09.033⟩
Boudhabhay, I, Poillerat, V, Grunenwald, A, Torset, C, Leon, J, Daugan, M V, Lucibello, F, El Karoui, K, Ydee, A, Chauvet, S, Girardie, P, Sacks, S, Farrar, C A, Garred, P, Berthaud, R, Le Quintrec, M, Rabant, M, de Lonlay, P, Rambaud, C, Gnemmi, V, Fremeaux-Bacchi, V, Frimat, M & Roumenina, L T 2021, ' Complement activation is a crucial driver of acute kidney injury in rhabdomyolysis ', Kidney International, vol. 99, no. 3, pp. 581-597 . https://doi.org/10.1016/j.kint.2020.09.033
International audience; Rhabdomyolysis is a life-threatening condition caused by skeletal muscle damage with acute kidney injury being the main complication dramatically worsening the prognosis. Specific treatment for rhabdomyolysis-induced acute kid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05fcfb3fe2891514d99a2c2ca77f693e
https://hal.sorbonne-universite.fr/hal-02985589/document
https://hal.sorbonne-universite.fr/hal-02985589/document
Publikováno v:
Frontiers in Immunology, Vol 3 (2012)
Investigations into the role of complement in ischaemia/reperfusion injury have identified common effector mechanisms that depend on the production of C5a and C5b-9 through the cleavage of C3. These studies have also defined an important role for C3
Externí odkaz:
https://doaj.org/article/f3e97c81c30541da89238c8803bc75b7
Autor:
Wuding Zhou, Weiju Wu, Chengfei Liu, Steven H. Sacks, Ke Li, Conrad A. Farrar, Liang Ma, Xia Dong
Publikováno v:
Wu, W, Liu, C, Farrar, C A, Ma, L, Dong, X, Sacks, S H, Li, K & Zhou, W 2018, ' Collectin-11 Promotes the Development of Renal Tubulointerstitial Fibrosis ', Journal of the American Society of Nephrology : JASN, vol. 29, no. 1, pp. 168-181 . https://doi.org/10.1681/ASN.2017050544
Collectin-11 is a recently described soluble C-type lectin, a pattern recognition molecule of the innate immune system that has distinct roles in host defense, embryonic development, and acute inflammation. However, little is known regarding the role
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30605516b9e366386a5eb7a39852df76
https://doi.org/10.1681/asn.2017050544
https://doi.org/10.1681/asn.2017050544
Publikováno v:
Seminars in Immunopathology
Pattern recognition molecules are sensors for the innate immune system and trigger a number of pathophysiological functions after interaction with the corresponding ligands on microorganisms or altered mammalian cells. Of those pattern recognition mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81cd0967718ba9e18db449a909f2fe77
https://doi.org/10.1007/s00281-017-0642-0
https://doi.org/10.1007/s00281-017-0642-0