Výsledky vyhledávání - "Conrad Bessant"

Akademický článek

Single-cell phenotypes of peripheral blood immune cells in early and late stages of non-alcoholic fatty liver disease

Autor: Kathryn Jane Waller, Hajar Saihi, Wenhao Li, James Hallimond Brindley, Anja De Jong, Wing-kin Syn, Conrad Bessant, William Alazawi

Publikováno v: Clinical and Molecular Hepatology, Vol 29, Iss 2, Pp 417-432 (2023)

Background/Aims Immune and inflammatory cells respond to multiple pathological hits in the development of nonalcoholic steatohepatitis (NASH) and fibrosis. Relatively little is known about how their type and function change through the non-alcoholic

Externí odkaz: https://doaj.org/article/c8a158e68d7e4092842e8e454a51150f

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Akademický článek

Community detection in empirical kinase networks identifies new potential members of signalling pathways.

Autor: Celia De Los Angeles Colomina Basanta, Marya Bazzi, Maruan Hijazi, Conrad Bessant, Pedro R Cutillas

Publikováno v: PLoS Computational Biology, Vol 19, Iss 6, p e1010459 (2023)

Phosphoproteomics allows one to measure the activity of kinases that drive the fluxes of signal transduction pathways involved in biological processes such as immune function, senescence and cell growth. However, deriving knowledge of signalling netw

Externí odkaz: https://doaj.org/article/6ea4b07a280243fe9d1d668fc29d361f

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Elektronická kniha

Building Bioinformatics Solutions

Autor: Conrad Bessant, Darren Oakley, Ian Shadforth

Bioinformatics encompasses a broad and ever-changing range of activities involved with the management and analysis of data from molecular biology experiments. Despite the diversity of activities and applications, the basic methodology and core tools

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Akademický článek

Blood pro-resolving mediators are linked with synovial pathology and are predictive of DMARD responsiveness in rheumatoid arthritis

Autor: Esteban A. Gomez, Romain A. Colas, Patricia R. Souza, Rebecca Hands, Myles J. Lewis, Conrad Bessant, Costantino Pitzalis, Jesmond Dalli

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)

Abstract Biomarkers are needed for predicting the effectiveness of disease modifying antirheumatic drugs (DMARDs). Here, using functional lipid mediator profiling and deeply phenotyped patients with early rheumatoid arthritis (RA), we observe that pe

Externí odkaz: https://doaj.org/article/f34fbd1c4b4842aeb4be2cce58f65db2

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Akademický článek

Analysis of mental and physical disorders associated with COVID-19 in online health forums: a natural language processing study

Autor: Rashmi Patel, Jessica Irving, Fabrizio Smeraldi, Maryam Abdollahyan, Conrad Bessant

Publikováno v: BMJ Open, Vol 11, Iss 11 (2021)

Objectives Online health forums provide rich and untapped real-time data on population health. Through novel data extraction and natural language processing (NLP) techniques, we characterise the evolution of mental and physical health concerns relati

Externí odkaz: https://doaj.org/article/11e075cdb9f147ed905e7aa0c6da72fd

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