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Akademický článek

CNTools: A computational toolbox for cellular neighborhood analysis from multiplexed images.

Autor: Yicheng Tao, Fan Feng, Xin Luo, Conrad V Reihsmann, Alexander L Hopkirk, Jean-Philippe Cartailler, Marcela Brissova, Stephen C J Parker, Diane C Saunders, Jie Liu

Publikováno v: PLoS Computational Biology, Vol 20, Iss 8, p e1012344 (2024)

Recent studies show that cellular neighborhoods play an important role in evolving biological events such as cancer and diabetes. Therefore, it is critical to accurately and efficiently identify cellular neighborhoods from spatially-resolved single-c

Externí odkaz: https://doaj.org/article/fa5d8a4580c940c98d6914fa30f9c20e

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Akademický článek

Investigation of some plant stilbenoids and their fragments for the identification of inhibitors of SARS-CoV-2 viral spike/ACE2 protein binding

Autor: Cyril T. Namba-Nzanguim, Conrad V. Simoben, Boris D. Bekono, Ian Tietjen, Joel Cassel, Joseph M. Salvino, Luis J. Montaner, Rohan A. Davis, Fidele Ntie-Kang

Publikováno v: The Microbe, Vol 3, Iss , Pp 100059- (2024)

In silico binding studies were conducted on the known plant-derived polyphenolic tetrameric stilbenoids, (–)-hopeaphenol (1), vaticanol B (2) and vatalbinoside A (3) and their monomeric derivative resveratrol (8), identified from several plant spec

Externí odkaz: https://doaj.org/article/afc2075cc7264f5a8d0c9e22bd2b420d

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Akademický článek

Genetic and epigenetic features of bilateral Wilms tumor predisposition in patients from the Children’s Oncology Group AREN18B5-Q

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)

Abstract Developing synchronous bilateral Wilms tumor suggests an underlying (epi)genetic predisposition. Here, we evaluate this predisposition in 68 patients using whole exome or genome sequencing (n = 85 tumors from 61 patients with matched germlin

Externí odkaz: https://doaj.org/article/946f460fad5e41959f9465bb4f236137

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Akademický článek

The role of surgery for anaplastic thyroid carcinoma in the era of targeted therapeutics: A scoping review

Autor: Eoin F. Cleere, Thomas J. Crotty, Justin M. Hintze, Conall W. R. Fitzgerald, John Kinsella, Paul Lennon, Conrad V. I. Timon, Robbie S. R. Woods, Neville P. Shine, James P. O'Neill

Publikováno v: Laryngoscope Investigative Otolaryngology, Vol 8, Iss 6, Pp 1673-1684 (2023)

Abstract Background Questions exist regarding patient selection for surgery in anaplastic thyroid carcinoma (ATC), particularly with the advent of neoadjuvant‐targeted therapeutics. The present scoping review sought to evaluate what extent of surgi

Externí odkaz: https://doaj.org/article/e6e7dba1616c4f01a2c23ebdd77c8a81

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