Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Conor W. Sipe"'
Publikováno v:
BioTechniques, Vol 37, Iss 5, Pp 768-776 (2004)
Microarray technology has become an important tool for studying large-scale gene expression for a diversity of biological applications. However, there are a number of experimental settings for which commercial arrays are either unsuitable or unavaila
Externí odkaz:
https://doaj.org/article/30bc97806611468f97d79101995649bc
Autor:
Conor W Sipe, Sarah E Siegrist
Publikováno v:
eLife, Vol 6 (2017)
Cell proliferation is coupled with nutrient availability. If nutrients become limited, proliferation ceases, because growth factor and/or PI3-kinase activity levels become attenuated. Here, we report an exception to this generality within a subpopula
Externí odkaz:
https://doaj.org/article/9949b72ef568425c8cccaec57e2259d0
Publikováno v:
PLoS Biology, Vol 18, Iss 5, p e3000721 (2020)
PLoS Biology
PLoS Biology
Dietary nutrients provide macromolecules necessary for organism growth and development. In response to animal feeding, evolutionarily conserved growth signaling pathways are activated, leading to increased rates of cell proliferation and tissue growt
Publikováno v:
PLoS Biology, Vol 19, Iss 10, p e3001438 (2021)
[This corrects the article DOI: 10.1371/journal.pbio.3000721.].
Autor:
Conor W. Sipe, Xiaowei Lu
Publikováno v:
WIREs Developmental Biology. 5:85-101
Hearing loss is the most common and costly sensory defect in humans and genetic causes underlie a significant proportion of affected individuals. In mammals, sound is detected by hair cells (HCs) housed in the cochlea of the inner ear, whose function
Publikováno v:
Current Biology. 22:956-966
Summary Background Planar cell polarity (PCP) signaling is a key regulator of epithelial morphogenesis, including neural tube closure and the orientation of inner ear sensory hair cells, and is mediated by a conserved noncanonical Wnt pathway. Ptk7 i
Autor:
Xiaowei Lu, Conor W. Sipe
Publikováno v:
Development. 138:3441-3449
Auditory hair cells represent one of the most prominent examples of epithelial planar polarity. In the auditory sensory epithelium, planar polarity of individual hair cells is defined by their V-shaped hair bundle, the mechanotransduction organelle l
Publikováno v:
The Journal of Neuroscience. 29:15859-15869
Morphogenesis of sensory hair cells, in particular their mechanotransduction organelle, the stereociliary bundle, requires highly organized remodeling of the actin cytoskeleton. The roles of Rho family small GTPases during this process remain unknown
Publikováno v:
The Journal of Comparative Neurology. 495:645-657
Proper functioning of the adult nervous system is critically dependent on neurons adopting the correct neurotransmitter phenotype during early development. Whereas the importance of cell-cell communication in fate determination is well documented for