Výsledky vyhledávání - "Conor W. Crean"

Targeting of photooxidative damage on single-stranded DNA representing the bcr-abl chimeric gene using oligonucleotide-conjugates containing [Ru(phen)3]2+-like photosensitiser groups

Autor: Mark Lawler, R. Jeremy H. Davies, Clare M. O'Keeffe, Yvonne Kavanagh, Peter H. Boyle, Clarke Stevenson, John M. Kelly, Conor W. Crean

Publikováno v: Photochemical & Photobiological Sciences. 1:1024-1033

Photooxidative damage was induced predominantly at a single guanine base in a target DNA by irradiation (lambda > 330 nm) in the presence of complementary oligodeoxynucleotide conjugates (ODN-5'-linker-[Ru(phen)3]2+) (phen = 1,10-phenanthroline). The

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ac1f4ac8265cbf50995a86b7c09afc4
https://doi.org/10.1039/b207387k

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Synthesis of N3- and 2-NH2-substituted 6,7-diphenylpterins and their use as intermediates for the preparation of oligonucleotide conjugates designed to target photooxidative damage on single-stranded DNA representing the bcr-abl chimeric gene

Autor: Russell Camier, John M. Kelly, Conor W. Crean, Clarke Stevenson, Mark Lawler, R. Jeremy H. Davies, Peter H. Boyle

Publikováno v: Organicbiomolecular chemistry. 2(24)

Two 17-mer oligodeoxynucleotide-5′-linked-(6,7-diphenylpterin) conjugates, 2 and 3, were prepared as photosensitisers for targeting photooxidative damage to a 34-mer DNA oligodeoxynucleotide (ODN) fragment 1 representing the chimeric bcr–abl gene

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa5062f1099de47571f05fc65ed80b38
https://pubmed.ncbi.nlm.nih.gov/15592617

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