Zobrazeno 1 - 10
of 249
pro vyhledávání: '"Conor R. Caffrey"'
Autor:
Lawrence J. Liu, Bobby Lucero, Cindy Manriquez-Rodriguez, Karol R. Francisco, Thaiz R. Teixeira, Darius J. Yohannan, Carlo Ballatore, Samuel A. Myers, Anthony J. O’Donoghue, Conor R. Caffrey
Publikováno v:
ACS Omega, Vol 9, Iss 32, Pp 34829-34840 (2024)
Externí odkaz:
https://doaj.org/article/216d446cd15c4572865786ea4be7e282
Autor:
Ramon M. Cogo, Thaís F. A. Pavani, Ana C. A. Mengarda, Rayssa A. Cajas, Thainá R. Teixeira, Lucas Fukui-Silva, Yujie Uli Sun, Lawrence J. Liu, Dilini K. Amarasinghe, Michael C. Yoon, Osvaldo A. Santos-Filho, Josué de Moraes, Conor R. Caffrey, Daniela G. G. Rando
Publikováno v:
ACS Omega, Vol 9, Iss 23, Pp 25356-25369 (2024)
Externí odkaz:
https://doaj.org/article/294f1189245f4f058bf87eae25b0fa89
Autor:
Gustavo Souza dos Santos, Thais Luz de Souza, Thaiz Rodrigues Teixeira, João Pedro Cezário Brandão, Keila Almeida Santana, Luan Henrique Santos Barreto, Samantha de Souza Cunha, Daniele Cristina Muniz Batista dos Santos, Conor R. Caffrey, Natan Silva Pereira, Aníbal de Freitas Santos Júnior
Publikováno v:
Molecules, Vol 28, Iss 11, p 4285 (2023)
Brazil has a megadiversity that includes marine species that are distributed along 800 km of shoreline. This biodiversity status holds promising biotechnological potential. Marine organisms are important sources of novel chemical species, with applic
Externí odkaz:
https://doaj.org/article/c06e46028bfb4e3782d1fc4558e2278d
Autor:
Steven Chen, Brian M. Suzuki, Jakob Dohrmann, Rahul Singh, Michelle R. Arkin, Conor R. Caffrey
Publikováno v:
Communications Biology, Vol 3, Iss 1, Pp 1-9 (2020)
Steven Chen et al. develop an automated, time-lapsed, high-content screen to quantify the responses of Schistosoma mansoni larvae to chemical insult. They apply their method to evaluate 45 static and kinetic response endpoints for seven drugs and scr
Externí odkaz:
https://doaj.org/article/888782e568404fa1a89115d3e9a03ab1
Autor:
Yi-Ting Yeh, Danielle E. Skinner, Ernesto Criado-Hidalgo, Natalie Shee Chen, Antoni Garcia-De Herreros, Nelly El-Sakkary, Lawrence Liu, Shun Zhang, Adithan Kandasamy, Shu Chien, Juan C. Lasheras, Juan C. del Álamo, Conor R. Caffrey
Publikováno v:
PLoS Pathogens, Vol 18, Iss 3 (2022)
The eggs of the parasitic blood fluke, Schistosoma, are the main drivers of the chronic pathologies associated with schistosomiasis, a disease of poverty afflicting approximately 220 million people worldwide. Eggs laid by Schistosoma mansoni in the b
Externí odkaz:
https://doaj.org/article/5f4c0aff923341048fdafedb19685673
Autor:
Thomas S. Corrigan, Leilani M. Lotti Diaz, Sarah E. Border, Steven C. Ratigan, Kayla Q. Kasper, Daniel Sojka, Pavla Fajtova, Conor R. Caffrey, Guy S. Salvesen, Craig A. McElroy, Christopher M. Hadad, Özlem Doğan Ekici
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 1387-1402 (2020)
Aza-peptide aldehydes and ketones are a new class of reversible protease inhibitors that are specific for the proteasome and clan CD cysteine proteases. We designed and synthesised aza-Leu derivatives that were specific for the chymotrypsin-like acti
Externí odkaz:
https://doaj.org/article/31bf5971d3b54bc09b1c70a575cfb101
Autor:
Obaid Hayat, Nazif Ullah, Muhammad Sirajuddin, Miriam A. Giardini, Jennifer V. Nguyen, Karol R. Francisco, Lawrence J. Liu, Yujie Uli Sun, Svetlana Maurya, Dominic McGrosso, David J. Gonzalez, Conor R. Caffrey, Anjan Debnath, Jair L. Siqueira-Neto
Publikováno v:
Pathogens, Vol 11, Iss 12, p 1424 (2022)
Metals have been used in medicine since ancient times for the treatment of different ailments with various elements such as iron, gold and arsenic. Metal complexes have also been reported to show antibiotic and antiparasitic activity. In this context
Externí odkaz:
https://doaj.org/article/3a11b00416ca4f92923dce5b3db08fed
Autor:
Martina Maccesi, Pedro H. N. Aguiar, Valérian Pasche, Melody Padilla, Brian M. Suzuki, Sandro Montefusco, Ruben Abagyan, Jennifer Keiser, Marina M. Mourão, Conor R. Caffrey
Publikováno v:
Parasites & Vectors, Vol 12, Iss 1, Pp 1-10 (2019)
Abstract Background Over the past five years, as a public service to encourage and accelerate drug discovery for diseases of poverty, the Medicines for Malaria Venture (MMV) has released box sets of 400 compounds named the Malaria, Pathogen and Stasi
Externí odkaz:
https://doaj.org/article/409ebe9371c34ff0b5f701fa37ac4641
Autor:
Salisa Chaimon, Yanin Limpanont, Onrapak Reamtong, Sumate Ampawong, Orawan Phuphisut, Phiraphol Chusongsang, Jiraporn Ruangsittichai, Usa Boonyuen, Dorn Watthanakulpanich, Anthony J. O’Donoghue, Conor R. Caffrey, Poom Adisakwattana
Publikováno v:
Parasites & Vectors, Vol 12, Iss 1, Pp 1-18 (2019)
Abstract Background Schistosoma mekongi, which causes schistosomiasis in humans, is an important public health issue in Southeast Asia. Treatment with praziquantel is the primary method of control but emergence of praziquantel resistance requires the
Externí odkaz:
https://doaj.org/article/516e02e9c2754eedb011c00c06f9fb76
Autor:
Alan R. Wolfe, R. Jeffrey Neitz, Mark Burlingame, Brian M. Suzuki, KC Lim, Mark Scheideler, David L. Nelson, Leslie Z. Benet, Conor R. Caffrey
Publikováno v:
International Journal for Parasitology: Drugs and Drug Resistance, Vol 8, Iss 3, Pp 571-586 (2018)
Treatment of schistosomiasis relies precariously on just one drug, praziquantel (PZQ). In the search for alternatives, 15 S-[2-(alkylamino)alkane] thiosulfuric acids were obtained from a previous research program and profiled in mice for efficacy aga
Externí odkaz:
https://doaj.org/article/7ed64300428e4730a8f663a65ab0444e