Uptake of severe acute respiratory syndrome coronavirus 2 spike protein mediated by angiotensin converting enzyme 2 and ganglioside in human cerebrovascular cells

Autor: Conor McQuaid, Alexander Solorzano, Ian Dickerson, Rashid Deane

Publikováno v: Frontiers in Neuroscience, Vol 17 (2023)

IntroductionThere is clinical evidence of neurological manifestations in coronavirus disease-19 (COVID-19). However, it is unclear whether differences in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)/spike protein (SP) uptake by cells

Externí odkaz: https://doaj.org/article/d8213073c3ba432ab8f7a8b50020cc19

SARS-CoV-2: is there neuroinvasion?

Autor: Conor McQuaid, Molly Brady, Rashid Deane

Publikováno v: Fluids and Barriers of the CNS, Vol 18, Iss 1, Pp 1-21 (2021)

Abstract Background SARS-CoV-2, a coronavirus (CoV), is known to cause acute respiratory distress syndrome, and a number of non-respiratory complications, particularly in older male patients with prior health conditions, such as obesity, diabetes and

Externí odkaz: https://doaj.org/article/6dd7c58d80d14132932e77bc9f762b8c

Comparison of polypeptides that bind the transferrin receptor for targeting gold nanocarriers.

Autor: Conor McQuaid, Andrea Halsey, Maëva Dubois, Ignacio Romero, David Male

Publikováno v: PLoS ONE, Vol 16, Iss 6, p e0252341 (2021)

The ability to target therapeutic agents to specific tissues is an important element in the development of new disease treatments. The transferrin receptor (TfR) is one potential target for drug delivery, as it expressed on many dividing cells and on

Externí odkaz: https://doaj.org/article/3f44ca1c0c7b4826b97f016485872453

SARS-CoV-2 and vascular dysfunction:a growing role for pericytes

Autor: Conor McQuaid, Axel Montagne

Publikováno v: McQuaid, C & Montagne, A 2022, ' SARS-CoV-2 and vascular dysfunction : a growing role for pericytes ', Cardiovascular Research . https://doi.org/10.1093/cvr/cvac143

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::325c87a5e2076e9cda5b264312c0684b
https://hdl.handle.net/20.500.11820/7db05207-fd0b-4897-9742-e228dedb2a5c

Cerebrospinal fluid drainage kinetics across the cribriform plate are reduced with aging

Autor: Ronald W. Wood, Molly Brady, Abigail Combs, Wingchi E. Kwok, Conor McQuaid, Akib Rahman, Chethana Venkatraman, R. Tristan Kasper, Rashid Deane

Publikováno v: Fluids and Barriers of the CNS, Vol 17, Iss 1, Pp 1-16 (2020)
Fluids and Barriers of the CNS

Background Continuous circulation and drainage of cerebrospinal fluid (CSF) are essential for the elimination of CSF-borne metabolic products and neuronal function. While multiple CSF drainage pathways have been identified, the significance of each t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::380aebc9227812d6d0eca5fbf0060d02
https://doaj.org/article/ea9f055752074b1183c142c1233e16d1