Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Conor McMahon"'
Autor:
Fortunato Ferrara, Adeline Fanni, Andre A. R. Teixeira, Esteban Molina, Camila Leal-Lopes, Ashley DeAguero, Sara D’Angelo, M. Frank Erasmus, Laura Spector, Luis Antonio Rodriguez Carnero, Jianquan Li, Thomas J. Pohl, Nikolai Suslov, Klervi Desrumeaux, Conor McMahon, Sagar Kathuria, Andrew R. M. Bradbury
Publikováno v:
mAbs, Vol 16, Iss 1 (2024)
We previously described an in vitro single-chain fragment (scFv) library platform originally designed to generate antibodies with excellent developability properties. The platform design was based on the use of clinical antibodies as scaffolds into w
Externí odkaz:
https://doaj.org/article/08adf8bbba7940a8b4cc3c5378c32316
Autor:
Jung-Eun Shin, Adam J. Riesselman, Aaron W. Kollasch, Conor McMahon, Elana Simon, Chris Sander, Aashish Manglik, Andrew C. Kruse, Debora S. Marks
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
The ability to design functional sequences is central to protein engineering and biotherapeutics. Here the authors introduce a deep generative alignment-free model for sequence design applied to highly variable regions and design and test a diverse n
Externí odkaz:
https://doaj.org/article/9f71edbc554b43bcb6739269e59cc88c
Publikováno v:
Drones, Vol 5, Iss 2, p 50 (2021)
Traditional acquisition methods for generating digital surface models (DSMs) of infrastructure are either low resolution and slow (total station-based methods) or expensive (LiDAR). By contrast, photogrammetric methods have recently received attentio
Externí odkaz:
https://doaj.org/article/0b1c0819ab01484f955b12bc9eee8b82
Autor:
Velasco Cimica, Sahar Saleem, Emily Matuczinski, Debra Adams-Fish, Conor McMahon, Sujatha Rashid, Timothy T. Stedman
Publikováno v:
Pathogens, Vol 10, Iss 6, p 680 (2021)
Powassan virus (POWV) is a tick-borne flavivirus circulating in North America and the Russian Far East that can cause severe neuroinvasive diseases, including encephalitis, meningitis, and meningoencephalitis. The reported neuroinvasive case fatality
Externí odkaz:
https://doaj.org/article/25bcf7204b38465d8728285a05c48956
Autor:
Mark S. Klempner, Matteo Stoppato, Alla Amcheslavsky, Jessica R. Pondish, Jordan Meisinger, Monir Ejemel, Ryan Schneider, Aaron Wallace, Qi Li, Yang Wang, Jacqueline R. Toomey, Raimond Heukers, Serena Giuntini, Lisa A. Cavacini, Eileen M. Barry, Zachary A. Schiller, Conor McMahon, Brian G. Pierce, Andrew C. Kruse
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Scientific Reports
Scientific Reports
Enterotoxigenic Escherichia coli (ETEC) is estimated to cause approximately 380,000 deaths annually during sporadic or epidemic outbreaks worldwide. Development of vaccines against ETEC is very challenging due to the vast heterogeneity of the ETEC st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::078cfdfd96ee937b4c593bb60c08d2bb
https://doaj.org/article/8c71423749de4016b747f5338a446935
https://doaj.org/article/8c71423749de4016b747f5338a446935
Autor:
Wayne L. Hubbell, Andrew C. Kruse, Robert J. Lefkowitz, Conor McMahon, Howard A. Rockman, Matthias Elgeti, Laura M. Wingler, Jialu Wang, Meredith A. Skiba, Dean P. Staus
Publikováno v:
Proc Natl Acad Sci U S A
There is considerable interest in developing antibodies as functional modulators of G protein-coupled receptor (GPCR) signaling for both therapeutic and research applications. However, there are few antibody ligands targeting GPCRs outside of the che
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39b35f906b7b9631e5554ad558505ea4
https://doi.org/10.1073/pnas.2009029117
https://doi.org/10.1073/pnas.2009029117
Autor:
Robert J. Lefkowitz, Alissa L. W. Kleinhenz, Meredith A. Skiba, Andrew C. Kruse, Carl-Mikael Suomivuori, Conor McMahon, Dean P. Staus, Ron O. Dror, Naomi R. Latorraca, Laura M. Wingler
Publikováno v:
Science
Choosing the drug to fit the protein Many approved drugs bind to G protein–coupled receptors (GPCRs). A challenge in targeting GPCRs is that different ligands preferentially activate different signaling pathways. Two papers show how biased signalin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d6a468f15f31a04e563eca4ab612dd6
https://doi.org/10.1126/science.aay9813
https://doi.org/10.1126/science.aay9813
Autor:
R. Grant Rowe, Daniel S. Pearson, Longfei Wang, Areum Han, Conor McMahon, Chunxiao Yu, Alexander S. Baier, William Marion, George Q. Daley, Andrew C. Kruse, Wanying Ji, Hao Wu, Yu-Chung Huang, Piotr Sliz
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Terminal uridylyltransferases are writers of poly(U) tails in diverse RNA uridylation pathways. In the let-7 pathway, the LIN28:pre-let-7:TUTase ribonucleoprotein complex regulates the processing and maturation of the let-7 microRNA, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebf31aa13bda3988a27b49f3120b1f79
http://europepmc.org/articles/PMC7060709
http://europepmc.org/articles/PMC7060709
Autor:
Timothy M. Caradonna, Jonathan Abraham, Kianna M. Nguyen, Chang C. Liu, Andrew C. Kruse, Aaron G. Schmidt, Debora S. Marks, Jung-Eun Shin, Jonathan R. Clements, Ming H. Ho, Blake M. Hauser, Conor McMahon, Vincent J. Hu, Morgan S.A. Gilman, Alon Wellner, Laura M. Wingler, Jared Feldman, Sarah Clark
Publikováno v:
Nat Chem Biol
Nature chemical biology, vol 17, iss 10
Nature chemical biology, vol 17, iss 10
The predominant approach for antibody generation remains animal immunization, which can yield exceptionally selective and potent antibody clones owing to the powerful evolutionary process of somatic hypermutation. However, animal immunization is inhe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe59caaa935ff143aaead32f6122dc8e
https://europepmc.org/articles/PMC8463502/
https://europepmc.org/articles/PMC8463502/
