Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Conor M. Henry"'
Autor:
Conor M. Henry, Carlos A. Castellanos, Michael D. Buck, Evangelos Giampazolias, Bruno Frederico, Ana Cardoso, Neil C. Rogers, Oliver Schulz, Sonia Lee, Johnathan Canton, Peter Faull, Ambrosius P. Snijders, Bhopal Mohapatra, Hamid Band, Caetano Reis e Sousa
Publikováno v:
Cell Reports, Vol 42, Iss 12, Pp 113506- (2023)
Summary: Cross-presentation of dead cell-associated antigens by conventional dendritic cells type 1 (cDC1s) is critical for CD8+ T cells response against many tumors and viral infections. It is facilitated by DNGR-1 (CLEC9A), an SYK-coupled cDC1 rece
Externí odkaz:
https://doaj.org/article/f17e0bebdccf4243bbe20ce69f73d27f
Publikováno v:
Open Biology, Vol 11, Iss 11 (2021)
The membranes of endosomes, phagosomes and macropinosomes can become damaged by the physical properties of internalized cargo, by active pathogenic invasion or by cellular processes, including endocytic maturation. Loss of membrane integrity is often
Externí odkaz:
https://doaj.org/article/b8b323d935d047ccba6ca37209913795
Autor:
Graeme P. Sullivan, Pavel B. Davidovich, Sylvia Sura‐Trueba, Ekaterina Belotcerkovskaya, Conor M. Henry, Danielle M. Clancy, Anna Zinoveva, Tazhir Mametnabiev, Alexander V. Garabadzhiu, Seamus J. Martin
Publikováno v:
FEBS Open Bio, Vol 8, Iss 5, Pp 751-763 (2018)
IL‐1 family cytokines act as apical initiators of inflammation in many settings and can promote the production of a battery of inflammatory cytokines, chemokines and other inflammatory mediators in diverse cell types. IL‐36α, IL‐36β and IL‐
Externí odkaz:
https://doaj.org/article/2d82acaa38b9470a81589218f59f6e90
Autor:
Danielle M. Clancy, Graeme P. Sullivan, Hannah B.T. Moran, Conor M. Henry, Emer P. Reeves, Noel G. McElvaney, Ed C. Lavelle, Seamus J. Martin
Publikováno v:
Cell Reports, Vol 22, Iss 11, Pp 2937-2950 (2018)
Summary: Neutrophil granule proteases are thought to function as anti-microbial effectors, cooperatively hydrolyzing microorganisms within phagosomes, or upon deployment into the extracellular space. However, evidence also suggests that neutrophil pr
Externí odkaz:
https://doaj.org/article/84b1f4ff03ca48e49b54d6cb7a3487cf
Autor:
Conor M. Henry, Graeme P. Sullivan, Danielle M. Clancy, Inna S. Afonina, Dagmar Kulms, Seamus J. Martin
Publikováno v:
Cell Reports, Vol 14, Iss 4, Pp 708-722 (2016)
Recent evidence has strongly implicated the IL-1 family cytokines IL-36α, IL-36β, and IL-36γ as key initiators of skin inflammation. Similar to the other members of the IL-1 family, IL-36 cytokines are expressed as inactive precursors and require
Externí odkaz:
https://doaj.org/article/5d52ec872f22480a931fea07b2ae2dd3
Autor:
Oliver Gordon, Conor M Henry, Naren Srinivasan, Susan Ahrens, Anna Franz, Safia Deddouche, Probir Chakravarty, David Phillips, Roger George, Svend Kjaer, David Frith, Ambrosius P Snijders, Rita S Valente, Carolina J Simoes da Silva, Luis Teixeira, Barry Thompson, Marc S Dionne, Will Wood, Caetano Reis e Sousa
Publikováno v:
eLife, Vol 7 (2018)
Damage-associated molecular patterns (DAMPs) are molecules exposed or released by dead cells that trigger or modulate immunity and tissue repair. In vertebrates, the cytoskeletal component F-actin is a DAMP specifically recognised by DNGR-1, an innat
Externí odkaz:
https://doaj.org/article/ee564ecab5b84fc6bb5c81c5b3bb58ec
Publikováno v:
Seminars in Immunology. 66:101726
Conventional dendritic cells type 1 (cDC1) are critical for inducing protective CD8+ T cell responses to tumour and viral antigens. In many instances, cDC1 access those antigens in the form of material internalised from dying tumour or virally-infect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f38da1994b41cde28af6e36143fff241
https://doi.org/10.1016/j.smim.2023.101726
https://doi.org/10.1016/j.smim.2023.101726
Autor:
Santiago Zelenay, Caetano Reis e Sousa, Felix Randow, Hefin Rhys, Neil C. Rogers, Hanna Blees, Oliver Schulz, Michael D. Buck, Cara J. Ellison, Conor M. Henry, Eleanor Childs, David C. Thomas, Venizelos Papayannopoulos, Johnathan Canton, Sebastian Amigorena, Andrés Alloatti, Lucy M. Collinson, Marie-Charlotte Domart
Publikováno v:
Nat Immunol
Nature Immunology
Nature Immunology, 2021, 22 (2), pp.140-153. ⟨10.1038/s41590-020-00824-x⟩
Nature Immunology
Nature Immunology, 2021, 22 (2), pp.140-153. ⟨10.1038/s41590-020-00824-x⟩
International audience; Type 1 conventional dendritic (cDC1) cells are necessary for cross-presentation of many viral and tumor antigens to CD8+ T cells. cDC1 cells can be identified in mice and humans by high expression of DNGR-1 (also known as CLEC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5096a9727f004540e3f878b16851a37
https://doi.org/10.1038/s41590-020-00824-x
https://doi.org/10.1038/s41590-020-00824-x
Publikováno v:
Open Biology
Open Biology, Vol 11, Iss 11 (2021)
Open Biology, Vol 11, Iss 11 (2021)
The membranes of endosomes, phagosomes and macropinosomes can become damaged by the physical properties of internalized cargo, by active pathogenic invasion or by cellular processes, including endocytic maturation. Loss of membrane integrity is often
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7c9818856e52d43a4ddfc519f79e525
http://europepmc.org/articles/PMC8580422
http://europepmc.org/articles/PMC8580422
