Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Conor M Smith"'
Autor:
Andreea Petrasca, Roisin Hambly, Oonagh Molloy, Sean Kearns, Barry Moran, Conor M Smith, Rosalind Hughes, Margaret O'Donnell, Alexandra Zaborowski, Desmond Winter, Jean M Fletcher, Brian Kirby, Anna Malara
Publikováno v:
PLoS ONE, Vol 18, Iss 2, p e0281688 (2023)
Hidradenitis suppurativa (HS) is a chronic relapsing inflammatory skin disease manifested as painful inflamed lesions including deep-seated nodules, abscesses and sinus tracts. The exact aetiology of HS is unclear. Recent evidence suggests that immun
Externí odkaz:
https://doaj.org/article/62b41f3c883844b0ac2ed03aa321a2d1
Autor:
Conor M Smith, Roisin Hambly, Solene Gatault, Luis F Iglesias-Martinez, Sean Kearns, Helen Rea, Vivien Marasigan, Kate Lynam-Loane, Shivashini Kirthi, Rosalind Hughes, Jean M Fletcher, Walter Kolch, Brian Kirby
Publikováno v:
British Journal of Dermatology. 188:290-310
Lesional HS skin was analysed using RNA-sequencing to assess the predicted functional interplay between B cells and macrophages. Our findings support the idea that TGF-beta plays a key role in HS pathogenesis. It is likely that the development of tun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::90b7b062d997af442b56762f8233db54
https://doi.org/10.1093/bjd/ljac048
https://doi.org/10.1093/bjd/ljac048
Autor:
Roisin Hambly, Solene Gatault, Conor M Smith, Luis F Iglesias-Martinez, Sean Kearns, Helen Rea, Vivien Marasigan, Kate Lynam-Loane, Shivashini Kirthi, Rosalind Hughes, Jean M Fletcher, Walter Kolch, Brian Kirby
Publikováno v:
British Journal of Dermatology. 188:52-63
Background Hidradenitis suppurativa (HS) is a chronic inflammatory skin disorder with significant morbidity. The pathogenesis remains incompletely understood although immune dysregulation plays an important role. It is challenging to treat and approx
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fb8810b5a5465ec4ad8f49f4388140f6
https://doi.org/10.1093/bjd/ljac007
https://doi.org/10.1093/bjd/ljac007
Autor:
Barry Moran, Conor M Smith, Alexandra Zabarowski, Mark Ryan, Jozsef Karman, Robert W Dunstan, Kathleen M Smith, Roisin Hambly, Jana Musilova, Andreea Petrasca, Aurelie Fabre, Margaret O’Donnell, Karsten Hokamp, Kingston H G Mills, William J Housley, Desmond C Winter, Brian Kirby, Jean M Fletcher
Publikováno v:
British Journal of Dermatology.
Background Treatment for the debilitating disease hidradenitis suppurativa (HS) is inadequate in many patients. Despite an incidence of approximately 1%, HS is often underrecognized and underdiagnosed and is associated with a high morbidity and poor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f6219c38955e10d03cb897e01af28d08
https://doi.org/10.1093/bjd/ljad184
https://doi.org/10.1093/bjd/ljad184
Autor:
Achilleas Floudas, Conor M Smith, Orla Tynan, Nuno Neto, Vinod Krishna, Sarah M Wade, Megan Hanlon, Clare Cunningham, Viviana Marzaioli, Mary Canavan, Jean M Fletcher, Ronan H Mullan, Suzanne Cole, Ling-Yang Hao, Michael G Monaghan, Sunil Nagpal, Douglas J Veale, Ursula Fearon
Publikováno v:
Annals of the rheumatic diseases.
ObjectivesImmune and stromal cell communication is central in the pathogenesis of rheumatoid arthritis (RA) and psoriatic arthritis (PsA), however, the nature of these interactions in the synovial pathology of the two pathotypes can differ. Identifyi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::110c5e26dff0c6ab9fbaf278f74d32a3
https://pubmed.ncbi.nlm.nih.gov/35821339
https://pubmed.ncbi.nlm.nih.gov/35821339
Autor:
Conor M. Smith, Shannon M. Saszik
Publikováno v:
Behavioural pharmacology. 29(1)
Stress has adverse effects on social behavior that is mediated by dopamine circuits in the midbrain. The purpose of this research is to examine the effect of chronic stress and dopamine signals on social behavior in zebrafish (Danio rerio). Chronic s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0214594d6016b0c562d4ef6f8098428a
https://pubmed.ncbi.nlm.nih.gov/28926343
https://pubmed.ncbi.nlm.nih.gov/28926343
Autor:
Brianne E. Barker, Megan M. Hanlon, Viviana Marzaioli, Conor M. Smith, Clare C. Cunningham, Jean M. Fletcher, Douglas J. Veale, Ursula Fearon, Mary Canavan
Publikováno v:
Frontiers in Medicine, Vol 10 (2023)
ObjectivesThe mammalian target of Rapamycin (mTOR) is a metabolic master regulator of both innate and adaptive immunity; however, its exact role in stromal cell biology is unknown. In this study we explored the role of the mTOR pathway on Rheumatoid
Externí odkaz:
https://doaj.org/article/0e55b94f1a6145e8b76fc1a644bfe9b2