Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Conor J Bloxham"'
Autor:
Katina D Hulme, Anjana C Karawita, Cassandra Pegg, Myrna JM Bunte, Helle Bielefeldt-Ohmann, Conor J Bloxham, Silvie Van den Hoecke, Yin Xiang Setoh, Bram Vrancken, Monique Spronken, Lauren E Steele, Nathalie AJ Verzele, Kyle R Upton, Alexander A Khromykh, Keng Yih Chew, Maria Sukkar, Simon Phipps, Kirsty R Short
Publikováno v:
eLife, Vol 10 (2021)
Influenza virus has a high mutation rate, such that within one host different viral variants can emerge. Evidence suggests that influenza virus variants are more prevalent in pregnant and/or obese individuals due to their impaired interferon response
Externí odkaz:
https://doaj.org/article/bf6df5e1336e47158a87381401c4414d
Autor:
Katina D Hulme, Limin Yan, Rebecca J Marshall, Conor J Bloxham, Kyle R Upton, Sumaira Z Hasnain, Helle Bielefeldt-Ohmann, Zhixuan Loh, Katharina Ronacher, Keng Yih Chew, Linda A Gallo, Kirsty R Short
Publikováno v:
eLife, Vol 9 (2020)
Diabetes mellitus is a known susceptibility factor for severe influenza virus infections. However, the mechanisms that underlie this susceptibility remain incompletely understood. Here, the effects of high glucose levels on influenza severity were in
Externí odkaz:
https://doaj.org/article/c77fdcadf032456989548c4375914ffe
Platelet mass cytometry reveals dysregulation of prothrombotic pathways in essential thrombocythemia
Autor:
Veronika Dill, Kilian Kirmes, Jiaying Han, Melissa Klug, Marc Rosenbaum, Giacomo Viggiani, Moritz von Scheidt, Markus List, Peter Herhaus, Jürgen Ruland, Florian Bassermann, Karl-Ludwig Laugwitz, Katharina S. Götze, Philipp J. Jost, Stefanie Jilg, Conor J. Bloxham, Philip W.J. Raake, Isabell Bernlochner, Dario Bongiovanni
Publikováno v:
Platelets, Vol 35, Iss 1 (2024)
Thromboembolic events are common in patients with essential thrombocythemia (ET). However, the pathophysiological mechanisms underlying the increased thrombotic risk remain to be determined. Here, we perform the first phenotypical characterization of
Externí odkaz:
https://doaj.org/article/6b03b9ff955e40ae9ff5ee319c518d34
Autor:
Jane E. Sinclair, Conor J. Bloxham, Han Chiu, Keng Yih Chew, Jake Russell, Yusuke Yoshikawa, Helle Bielefeldt-Ohmann, Lauren E. Steele, Katina D. Hulme, Nathalie AJ. Verzele, Ellesandra C. Noye, Melanie Wu, Melissa E. Reichelt, Walter G. Thomas, Linda A. Gallo, Meredith A. Redd, Kirsty R. Short
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 11 (2021)
People with diabetes mellitus are susceptible to both cardiovascular disease and severe influenza A virus infection. We hypothesized that diabetes also increases risks of influenza-associated cardiac complications. A murine type 1 (streptozotocin-ind
Externí odkaz:
https://doaj.org/article/a5d94dcaed7a4b54a8b0874e68cd9768
Autor:
Rebecca J. Marshall, Pornthida Armart, Katina D. Hulme, Keng Yih Chew, Alexandra C. Brown, Philip M. Hansbro, Conor J. Bloxham, Melanie Flint, Katharina Ronacher, Helle Bielefeldt-Ohmann, Linda A. Gallo, Kirsty R. Short
Publikováno v:
mBio, Vol 11, Iss 2 (2020)
ABSTRACT People with diabetes are two times more likely to die from influenza than people with no underlying medical condition. The mechanisms underlying this susceptibility are poorly understood. In healthy individuals, small and short-lived postpra
Externí odkaz:
https://doaj.org/article/e7526e11425e4113be3ebc0f2d499ad6
Autor:
Andrew P. Barbour, Kenneth Miles, Nicola Waddell, B. Mark Smithers, Samuel Yang, Gerard Bayley, Geoffrey Strutton, Phillip Law, Victoria Atkinson, Conor J. Bloxham, Julia J. Bradford, Kalpana Patel, Harald Oey, John V. Pearson, Marjan M. Naeini, Lambros T. Koufariotis, Shaun B. Walters, Sandra Brosda, Vanessa F. Bonazzi, Bernadette Z.Y. Wong, Lauren G. Aoude
Treatment for metastatic melanoma includes targeted and/or immunotherapy. Although many patients respond, only a subset has complete response. As late-stage patients often have multiple tumors in difficult access sites, non-invasive techniques are ne
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f97b1240044fb8b2cbde3e678fa16bff
https://doi.org/10.1158/1541-7786.c.6545076.v1
https://doi.org/10.1158/1541-7786.c.6545076.v1
Autor:
Andrew P. Barbour, Kenneth Miles, Nicola Waddell, B. Mark Smithers, Samuel Yang, Gerard Bayley, Geoffrey Strutton, Phillip Law, Victoria Atkinson, Conor J. Bloxham, Julia J. Bradford, Kalpana Patel, Harald Oey, John V. Pearson, Marjan M. Naeini, Lambros T. Koufariotis, Shaun B. Walters, Sandra Brosda, Vanessa F. Bonazzi, Bernadette Z.Y. Wong, Lauren G. Aoude
Kaplan-Meier (log-rank) analysis of MPP4 and SD3 showing the PFS and OS for stage III patients only. a. PFS for MPP4, **p=0.0017, b. OS for MPP4, *p=0.0117, c. PFS for SD3, ***p=0.0003 and d. OS for SD3, **p=0.0094.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08f040cccdef8feb541b68139b6f71b5
https://doi.org/10.1158/1541-7786.22526397
https://doi.org/10.1158/1541-7786.22526397
Autor:
Andrew P. Barbour, Kenneth Miles, Nicola Waddell, B. Mark Smithers, Samuel Yang, Gerard Bayley, Geoffrey Strutton, Phillip Law, Victoria Atkinson, Conor J. Bloxham, Julia J. Bradford, Kalpana Patel, Harald Oey, John V. Pearson, Marjan M. Naeini, Lambros T. Koufariotis, Shaun B. Walters, Sandra Brosda, Vanessa F. Bonazzi, Bernadette Z.Y. Wong, Lauren G. Aoude
Multiplex immunofluorescence staining quantification by Visiopharm Image Analytical System. DAPI nuclei were segmented defining the areas. Then each marker was quantified within this DAPI area. MPP4 low (MelR062) and MPP4 high (MelR166) phenotypes ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7146eeafe20b948699b45e4ce745c2ec
https://doi.org/10.1158/1541-7786.22526391.v1
https://doi.org/10.1158/1541-7786.22526391.v1
Autor:
Andrew P. Barbour, Kenneth Miles, Nicola Waddell, B. Mark Smithers, Samuel Yang, Gerard Bayley, Geoffrey Strutton, Phillip Law, Victoria Atkinson, Conor J. Bloxham, Julia J. Bradford, Kalpana Patel, Harald Oey, John V. Pearson, Marjan M. Naeini, Lambros T. Koufariotis, Shaun B. Walters, Sandra Brosda, Vanessa F. Bonazzi, Bernadette Z.Y. Wong, Lauren G. Aoude
Table S1. Patient Characteristics. AJCC: American Joint Committee on Cancer Table S2. Clinical information including histology, stage and survival. Table S3. Univariate analysis of clinico-pathological and CT features. Log-rank (Mantel-Cox) test to d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e238e944f47b1f9a7e90210ae6a21a80
https://doi.org/10.1158/1541-7786.22526388.v1
https://doi.org/10.1158/1541-7786.22526388.v1
Autor:
Andrew P. Barbour, Kenneth Miles, Nicola Waddell, B. Mark Smithers, Samuel Yang, Gerard Bayley, Geoffrey Strutton, Phillip Law, Victoria Atkinson, Conor J. Bloxham, Julia J. Bradford, Kalpana Patel, Harald Oey, John V. Pearson, Marjan M. Naeini, Lambros T. Koufariotis, Shaun B. Walters, Sandra Brosda, Vanessa F. Bonazzi, Bernadette Z.Y. Wong, Lauren G. Aoude
The association between TMB and SD3/MPP4 is not statistically significant. A. MPP4, not significant, Fisher's exact. B. SD3, not significant, Fisher's exact.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c83c28f7b9da633dc18a4e63a7475fb
https://doi.org/10.1158/1541-7786.22526394.v1
https://doi.org/10.1158/1541-7786.22526394.v1