Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Conor Garrod-Ketchley"'
Autor:
Lauren A. Callender, Johannes Schroth, Elizabeth C. Carroll, Conor Garrod-Ketchley, Lisa E. L. Romano, Eleanor Hendy, Audrey Kelly, Paul Lavender, Arne N. Akbar, J. Paul Chapple, Sian M. Henson
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
GATA3 has been considered to be primarily associated with CD4+ Th2 cell function. Using CD4+ effector memory that re-express CD45RA (EMRA) T cells the authors show that in response to DNA damage GATA3 can regulate increase of mitochondrial mass and b
Externí odkaz:
https://doaj.org/article/e3707e322df34c44b2251936c03964a1
Autor:
Lauren A. Callender, Elizabeth C. Carroll, Conor Garrod-Ketchley, Johannes Schroth, Jonas Bystrom, Victoria Berryman, Melanie Pattrick, Desiree Campbell-Richards, Gillian A. Hood, Graham A. Hitman, Sarah Finer, Sian M. Henson
Publikováno v:
Frontiers in Aging, Vol 2 (2021)
Mitochondrial health and cellular metabolism can heavily influence the onset of senescence in T cells. CD8+ EMRA T cells exhibit mitochondrial dysfunction and alterations to oxidative phosphorylation, however, the metabolic properties of senescent CD
Externí odkaz:
https://doaj.org/article/3d785a4ee8d34e03b1e989f0b39f8d14
Autor:
Jonas Bystrom, Amaia Carrascal-Miniño, George P Keeling, Truc Pham, Conor Garrod-Ketchley, Johannes Schroth, Rafael T. M. De Rosales, Samantha YA Terry, Sian M. Henson
The ability of CD8+ T cells to protect against infection and malignant transformation diminishes with age. Novel means to assess cells’ functional deficitsin vivoare being made available such as total-body positron emission tomography (PET) and rad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cea6756cdaf0b25f41b3fe3d58ede24b
https://doi.org/10.1101/2023.02.04.23285413
https://doi.org/10.1101/2023.02.04.23285413
Autor:
J. Paul Chapple, Audrey Kelly, Conor Garrod-Ketchley, Arne N. Akbar, Eleanor Hendy, Elizabeth C. Carroll, Lisa E.L. Romano, Johannes Schroth, Lauren A. Callender, Sian M. Henson, Paul Lavender
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
GATA3 is as a lineage-specific transcription factor that drives the differentiation of CD4+ T helper 2 (Th2) cells, but is also involved in a variety of processes such as immune regulation, proliferation and maintenance in other T cell and non-T cell