Zobrazeno 1 - 10
of 168
pro vyhledávání: '"Conor C Lynch"'
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 5, p e1009839 (2022)
Myeloid-derived monocyte and macrophages are key cells in the bone that contribute to remodeling and injury repair. However, their temporal polarization status and control of bone-resorbing osteoclasts and bone-forming osteoblasts responses is largel
Externí odkaz:
https://doaj.org/article/265fb605d8ab446dbbe717f21781d987
Autor:
David B Vaught, Alyssa R Merkel, Conor C Lynch, James Edwards, Mohammed Noor Tantawy, Timothy Hilliard, Shan Wang, Todd Peterson, Rachelle W Johnson, Julie A Sterling, Dana Brantley‐Sieders
Publikováno v:
JBMR Plus, Vol 5, Iss 4, Pp n/a-n/a (2021)
ABSTRACT EphA2 receptor tyrosine kinase (RTK) is highly expressed in breast tumor cells across multiple molecular subtypes and correlates with poor patient prognosis. In this study, the potential role of EphA2 in this clinically relevant phenomenon i
Externí odkaz:
https://doaj.org/article/e50828c08fb84f00868df19ee24dc038
Autor:
Ryan T. Bishop, Anna K. Miller, Matthew Froid, Niveditha Nerlakanti, Tao Li, Jeremy S. Frieling, Mostafa M. Nasr, Karl J. Nyman, Praneeth R. Sudalagunta, Rafael R. Canevarolo, Ariosto Siqueira Silva, Kenneth H. Shain, Conor C. Lynch, David Basanta
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Multiple myeloma (MM) is an osteolytic malignancy that is incurable due to the emergence of treatment resistant disease. Defining how, when and where myeloma cell intrinsic and extrinsic bone microenvironmental mechanisms cause relapse is ch
Externí odkaz:
https://doaj.org/article/6a891d57aa954ccea72f58bdbad908a5
Publikováno v:
Journal of Bone Oncology, Vol 47, Iss , Pp 100610- (2024)
The skeleton is a common site of cancer metastasis and malignancy with the resultant lesions often being incurable. Interactions between metastatic cancer cells and the bone microenvironment are critical for cancer cell survival, outgrowth, and progr
Externí odkaz:
https://doaj.org/article/55f3ce97c0354f99ad047eaedeaa7b4f
Autor:
Sophie Thiolloy, James R Edwards, Barbara Fingleton, Daniel B Rifkin, Lynn M Matrisian, Conor C Lynch
Publikováno v:
PLoS ONE, Vol 7, Iss 1, p e29862 (2012)
Breast to bone metastases frequently induce a "vicious cycle" in which osteoclast mediated bone resorption and proteolysis results in the release of bone matrix sequestered factors that drive tumor growth. While osteoclasts express numerous proteinas
Externí odkaz:
https://doaj.org/article/92a678089e744f57baf73db6171a78ed
Autor:
Manisha Shah, Dexing Huang, Tony Blick, Andrea Connor, Lawrence A Reiter, Joel R Hardink, Conor C Lynch, Mark Waltham, Erik W Thompson
Publikováno v:
PLoS ONE, Vol 7, Iss 1, p e29615 (2012)
We investigated the effects of the matrix metalloproteinase 13 (MMP13)-selective inhibitor, 5-(4-{4-[4-(4-fluorophenyl)-1,3-oxazol-2-yl]phenoxy}phenoxy)-5-(2-methoxyethyl) pyrimidine-2,4,6(1H,3H,5H)-trione (Cmpd-1), on the primary tumor growth and br
Externí odkaz:
https://doaj.org/article/403a71d5b97340b1adaf0dad03567717
Autor:
Ryan T. Bishop, Tao Li, Raghunandan R. Alugubelli, Mostafa Nasr, Karl J. Nyman, Praneeth Sudalagunta, Mark Meads, Jeremy Frieling, Niveditha Nerlakanti, Marilena Tauro, Oliver Hampton, Bin Fang, Steven Grant, John Koomen, Ariosto Siqueira Silva, Kenneth H. Shain, Conor C. Lynch
Publikováno v:
Journal of Bone Oncology, Vol 45, Iss , Pp 100539- (2024)
Externí odkaz:
https://doaj.org/article/521fc9dd9d7d46f098490ae18ec77b15
Autor:
Jeremy S. Frieling, Leticia Tordesillas, Xiomar E. Bustos, Maria Cecilia Ramello, Ryan T. Bishop, Junior E. Cianne, Sebastian A. Snedal, Tao Li, Chen Hao Lo, Janis de la Iglesia, Emiliano Roselli, Ismahène Benzaïd, Xuefeng Wang, Youngchul Kim, Conor C. Lynch, Daniel Abate-Daga
Publikováno v:
Science Advances. 9
Immune checkpoint blockade has been largely unsuccessful for the treatment of bone metastatic castrate-resistant prostate cancer (mCRPC). Here, we report a combinatorial strategy to treat mCRPC using γδ-enriched chimeric antigen receptor (CAR) T ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f40a9b602316ea315f33d27e79a0861f
https://doi.org/10.1126/sciadv.adf0108
https://doi.org/10.1126/sciadv.adf0108
Autor:
Ernst Schönbrunn, Nicholas J. Lawrence, Gary W. Reuther, Harshani R. Lawrence, Cyril H. Benes, Conor C. Lynch, Patricia Greninger, Paula J. Cranfill, Jin-Yi Zhu, Marilena Tauro, Muhammad Ayaz, Steven Gunawan, Norbert Berndt, Que T. Lambert, Stuart W. Ember
Table S1: Crystallographic data collection and refinement statistics Table S2: Inhibitory activity against other BET bromodomains Table S3: Bromodomain profiling data Fig. S1: Detailed binding interactions of compounds 1 - 5 in BRD4-1 Fig. S2: Compar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3a8658e8c0c794a279fbf75d3faea43
https://doi.org/10.1158/1535-7163.22504383.v1
https://doi.org/10.1158/1535-7163.22504383.v1
Autor:
Ernst Schönbrunn, Nicholas J. Lawrence, Gary W. Reuther, Harshani R. Lawrence, Cyril H. Benes, Conor C. Lynch, Patricia Greninger, Paula J. Cranfill, Jin-Yi Zhu, Marilena Tauro, Muhammad Ayaz, Steven Gunawan, Norbert Berndt, Que T. Lambert, Stuart W. Ember
Synergistic action of kinase and BET bromodomain inhibitors in cell killing has been reported for a variety of cancers. Using the chemical scaffold of the JAK2 inhibitor TG101348, we developed and characterized single agents which potently and simult
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::174289931beab104a62e35bd2bf1cb33
https://doi.org/10.1158/1535-7163.c.6537717.v1
https://doi.org/10.1158/1535-7163.c.6537717.v1